Indian Journal of Anaesthesia  
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CLINICAL INVESTIGATION
Year : 2007  |  Volume : 51  |  Issue : 3  |  Page : 205-210

Haemodynamic changes during laparoscopic cholccystectomy: Effect of clonidine premedication


1 PG Student, Department of Anaesthesiology, Medical College, Kolkata-73, India
2 MD, MNAMS, Professor & HOD., Department of Anaesthesiology, Medical College, Kolkata-73, India
3 DA, MD, Assistant Professor, Department of Anaesthesiology, Medical College, Kolkata-73, India

Correspondence Address:
Manjushree Ray
12/1, A. K. Point, 68B, A.P.C. Roy Road, Kolkata-700 009
India
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Source of Support: None, Conflict of Interest: None


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Clonidine has been shown to reduce perioperative haemodynamic instability. The aim of the study was to investigate the clinical efficiency of oral clonidine premedication in prevention of haemodynamic response associated with pneumoperitoneum. Sixty adult patients of ASA physical status I& II, scheduled for elective laparoscopic cholecystectomy were recruited for a prospective randomized, double-blinded comparative study. They were randomly allocated to one of the two groups to receive either oral clonidine 150 gg (Group C) or ranitidine 150 mg (Group P), 90 minute before induction of anaesthesia. Significant rise in heart rate was observed following pneumoperitoneum in Group P as compared to Group C (99.23±14.02 Vs 81.26±8.40 bpm). Similarly, rise in systolic arterial pressure (143.63±19.60 Vs 119.6±10.06 mm Hg), diastolic arterial pressure (99.23±14.02 Vs 81.26±8.40 mm Hg) and mean arterial pressure (114.13±16.57 Vs 93.83±8.107 mm Hg) was more in Group P following pneumoperitoneum. Nitroglycerine drip was started in 33.3% patients in Group P to control intraoperative hypertension. Incidence of postopera­tive nausea-vomiting and shivering was also less in Group C. To conclude, clonidine premedication provides perioperative haemodynamic stability, hence it can be recommended as a routine premedication for laparoscopic procedure.


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