Indian Journal of Anaesthesia  
About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions
Home | Login  | Users Online: 1255  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size    

Year : 2007  |  Volume : 51  |  Issue : 3  |  Page : 211-215

Effect of propofol and thiopentone on intracranial pressure and cerebral perfusion pressure in patients undergoing elective craniotomy - a comparative study

1 M.D., Asst. Professor, Department of Neuroanaesthesiology, Neuro ICU and Pain Clinic, Bangur Institute of Neurology, I.P.G.M.E. & R., Kolkata, India
2 M.D., Professor and HOD, Department of Neuroanaesthesiology, Neuro ICU and Pain Clinic, Bangur Institute of Neurology, I.P.G.M.E. & R., Kolkata, India

Correspondence Address:
Bibhukalyani Das
142, Rubypark East, Kolkata - 700078
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Advantages and disadvantages of newer agent like propofol need to be evaluated with time tested inducing drug - thiopentone in neuroanaesthesia. The aim of the study was to compare effects of propofol with thiopentone on intracranial pressure, cerebral perfusion pressure and haemodynamics during induction in neurosurgical pa­tients. Fifty adult patients of ASA grade I& II scheduled for elective craniotomy were randomly assigned to receive induction of anaesthesia with either propofol 1.5-2.5 -1 i.v. (Group A, n=25) or thiopentone 4-5 -1 , i.v. (Group B, n=25). Vecuronium bromide 0.1 -1 i.v. was used as intubating muscle relaxant. Both groups received fentanyl 2 -1 i.v., lidocaine(preservative free) 1.5 -1 i.v. and supplementary dose of same inducing agent before intubation. Changes in mean arterial pressure (MAP), cerebrospinal fluid pressure (CSFP), cerebral perfusion pressure (CPP) and heart rate (HR) were noted during induction and endotracheal intubation. On statistical analysis it was found that CSFP decreased significantly (P<0.001) in both groups after induction but endotracheal intubation did not provoke any significant rise in CSFP. Maximum decrease of CSFP was 35.26% in Group A and 35.20% in Group B. Fall in MAP was more significant in Group A (P<0.001), as a result CPP was significantly less in Group A than in Group B. The lowest mean CPP (71.12±5.86 mm Hg) was observed 2 minutes after induction dose in Group A when maximum drop in MAP occurred. Heart rate did not change significantly in Group A but in Group B fluctuation of heart rate was more.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded514    
    Comments [Add]    

Recommend this journal