Indian Journal of Anaesthesia  
About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions
Home | Login  | Users Online: 222  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size    




 
SPECIAL ARTICLE
Year : 2008  |  Volume : 52  |  Issue : 3  |  Page : 264-272 Table of Contents     

Paediatric Spinal Anesthesia


1 Consultant, Department of Anesthesiology and Critical Care, Base hospital, New Delhi, India
2 Head of Department, Department of Anesthesiology and Critical Care, Base hospital, New Delhi, India
3 P.G.Student, Department of Anesthesiology and Critical Care, Base hospital, New Delhi, India

Date of Web Publication19-Mar-2010

Correspondence Address:
Rakhee Goyal
Department of Anesthesiology and Critical Care, Base hospital, New Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions
 

Paediatric spinal anesthesia is not only a safe alternative to general anaesthesia but often the anaesthesia technique of choice in many lower abdominal and lower limb surgeries in children. The misconception regarding its safety and feasibility is broken and is now found to be even more cost-effective. It is a much preferred technique especially for the common daycase surgeries generally performed in the paediatric age group. There is no require­ment of any additional expensive equipment either and this procedure can be easily performed in peripheral centers. However, greater acceptance and experience is yet desired for this technique to become popular.

Keywords: Paediatric spinal anaesthesia, Bupivacaine, Infraumbilical surgeries in children


How to cite this article:
Goyal R, Jirtjil K, Baj B, Singh S, Kumar S. Paediatric Spinal Anesthesia. Indian J Anaesth 2008;52:264-72

How to cite this URL:
Goyal R, Jirtjil K, Baj B, Singh S, Kumar S. Paediatric Spinal Anesthesia. Indian J Anaesth [serial online] 2008 [cited 2017 Jul 26];52:264-72. Available from: http://www.ijaweb.org/text.asp?2008/52/3/264/60633


   Introduction Top


Regional anaesthesia in children was first studied by August Bier in 1899. Since then, spinal anaesthesia was known to be practiced for several years with a series of cases published as early as in 1909-1910. [1],[2],[3] In 1900, Bainbridge reported a case of strangulated hernia repair under spinal anaesthesia in an infant of three months. [4] Thereafter, Tyrell Gray, a British sur­geon published a series of 200 cases of lower abdomi­nal surgeries in infants and children under spinal anaes­thesia in 1909-1910. After some years it fell into dis­use because of the introduction of various muscle re­laxants and inhalational agents and was almost unused after World War II.

Thereafter, in 1983, in the American Society of Anesthesiologists Regional Anesthesia Breakfast Panel, Abajian et al started the "frenzy" of modern paediatric spinal anaesthesia when they reported 78 cases in 81 infants. [5] The textbook of paediatrics by Leigh and Belton also demonstrated that 10% of all anaesthetic proce­dures practiced in children at the Vancouver General Hospital were spinal techniques, including pulmonary lobectomies and pneumonectomies. [5] However, paedi­atric spinal anaesthesia never achieved its popularity because of continuous discoveries of newer and better volatile agents and muscle relaxants for general anaes­thesia.

In the last decade, it started being advocated again by many centers due to increasing knowledge on phar­macology, safety information and availability of spe­cialized equipment for regional anaesthetic techniques and monitoring in children. In the coming times, paedi­atric spinal anaesthesia will not only be used in cases where general anaesthesia is risky or contraindicated but also be the preferred choice in most lower abdominal and lower extremity surgeries in children.


   Anatomical and physiological differences in children Top


There are certain features of paediatric anatomy and physiology which are different from the adult and thus make the central neuraxial blockade a good alter­native anaesthetic technique. The spinal cord ends at L3 level at birth and reaches L-1 by 6-12 months. The dural sac is at the S4 level at birth and reaches S2 by the end of the first year. The line joining the two supe­rior iliac crests (inter-cristal line) crosses at L5-S1 in­terspace at birth, L5 vertebra in young children and L3/4 interspace in adults. It is for this reason that the lumbar puncture be done at a level below which the cord ends, safest being at or below the inter cristal line. The bones of the sacrum are not fused posteriorly in children enabling an access to the subarachnoid space even at this level.

Another feature which is unique in infants is that there is only one anterior concave curvature of the ver­tebral column at birth. The cervical lordosis begins in the first 3 months of life with the child's ability to hold the head upright. The lumbar lordosis starts as the child begins to walk at the age of 6-9 months. Therefore, the spread of isobaric local anaesthetic is different in in­fants particularly as compared to adults.

The subarachnoid space is incompletely divided by the denticulate ligament laterally, and the subarach­noid septum medially. The volume of cerebrospinal fluid CSF is 4 ml.kg -1 which is double the adult volume. Moreover, in infants half of this volume is in the spinal space whereas adults have only one-fourth. This sig­nificantly affects the pharmocokinetics of intrathecal drugs. The spinal fluid hydrostatic pressure of 30-40mm H 2 O in horizontal position is also much less than that in adults. [6]

The neck can be in extension for lateral position­ing while performing a lumbar puncture as cervical flex­ion is of no benefit in children and in fact, may obstruct the airway during the procedure. It can also be per­formed in sitting position with the head extended.

The physiological impact of sympathectomy is minimal or none in smaller age groups. The fall in blood pressure and a drop in the heart rate are practically not seen in children less than five years. Therefore there is no role of preloading with fluids before a subarachnoid block. This may be due to the immature sympathetic nervous system in children younger than five-eight years or a result of the relatively small intravascular volume in the lower extremities and splanchnic system limiting venous pooling and relatively vasodilated peripheral blood vessels. [7] Infants respond to high thoracic spinal anaesthesia by reflex withdrawal of vagal parasympa­thetic tone to the heart. It is one of the reasons why spinal anaesthesia has been the technique of choice in critically ill and moribund neonates who present for surgery in grave haemodynamic instability.


   Pharmacology Top


The most important concern with the use of in­trathecal local anaesthetics in infants and young chil­dren is the risk of toxicity. This age group is particularly prone to direct toxicity to the spinal cord when admin­istered in large doses. Neonates with immature hepatic metabolism and decreased plasma proteins like albu­min and cc 1 acid glycoprotein have higher serum lev­els of unbound amide local anaesthetics, which are nor­mally highly protein bound (90%). A relatively higher cardiac output and regional blood flow in infants also increases the drug uptake from neuraxial spaces and can predispose them to local anaesthetic toxicity be­sides decreasing the duration of action. Infants may have decreased levels of plasma pseudocholinesterase which may augment local anaesthetic toxicity especially with the ester group. [8] Various anaesthetics have been used for paediatric spinal anaesthesia but bupivacaine and ropivacaine remain the drugs of choice.


   Indications Top


Infraumbilical extraperitoneal surgeries like ing­uinal hernia, circumcision, hypospadias, orchidopexy, cystoscopy, colostomy for imperforate anus, rectal bi­opsy and other perineal surgeries; lower extremity or­thopaedic and reconstructive surgeries.

Preterm and former preterm infants less than 60 weeks post-conceptual age/less than 3 Kg/hematocrit <30% and with other co-morbidities who are prone to post-operative apnoea, [9] bradycardia and desaturation after general anaesthesia.

Neonates with respiratory diseases like bronchop­ulmonary dysplasias, hyaline membrane disease.

Children with history of or high risk for malignant hyperthermia .

Children with acute respiratory conditions, chronic disease of the airways like asthma or cystic fibrosis.

Besides these common indications, there are re­ports of successful spinal anaesthesia in complex sur­geries like meningomyelocele, gastroschisis repair, open heart surgery [10] etc in addition to light general anaes­thesia.


   Contraindications Top


Refusal of the parents, progressive neurological disease, uncontrolled convulsions, infection of the skin or subcutaneous tissue locally at puncture site, coagu­lation defects, true allergy to local anaesthetics and se­vere hypovolemia are some of the contraindications to spinal anaesthesia in children.


   Consent and risk-benefit aspect Top


Consent from the parents is an important issue before planning a central neuraxial blockade for chil­dren. The consent should be informed and written, and the various aspects of regional technique alongwith the risks involved must be explained in detail. There is also an obvious need to assess the risk involved in the pro­cedure on an individual case basis versus the benefits expected depending on the nature and duration of sur­gery, general condition of the patient and the availabil­ity of institutional care intra and postoperatively.


   NPO and premedication protocols Top


The standard preoperative fasting guidelines are required to be followed before elective spinal anaes­thesia. 2-3 hrs fasting for clear fluids, 4 hrs for other fluids and 6 hrs for solids is usually followed in most centers.

Adequate premedication is the key to a smooth regional procedure in children. Various drugs via dif­ferent routes may be used to achieve a well sedated child who allows venous puncture, placement of moni­tors and even a lumbar puncture. Oral combination of ketamine 4-6mg.kg -1 , midazolam 0.4mg.kg -1 and atro­pine 0.03mg.kg -1 is quite effective and safe in most cases. [6] Other routes of premedication like rectal, sub­lingual, nasal or intramuscular are also practiced. What­ ever may be the drug and the route of administration, it is important that it is customized for each type of pa­tient and surgery involved and also safe during the en­tire perioperative period. [11]


   Procedure, needles used, drug dose Top


The basic procedure of performing a subarach­noid block in children is similar to adults and full asep­tic precautions are a must. It is important to access the CSF through appropriate space as per the age of the child as already discussed in order to avoid trauma to the spinal cord. Care should be taken as the child may be asleep or inadequately sedated. However, additional analgesia and sedation is generally required during lum­bar puncture. It may be supplemented with low dose ketamine or a short acting drug like thiopental/propofol intravenously or inhalational anaesthetics like oxygen­nitrous oxide, sevoflurane or halothane during the pro­cedure. Anticholinergic drugs may be added to decrease any undesired secretions. Application of 5% EMLA (eutectic mixture of local anaesthetics-lidocaine and prilocaine) with an occlusive dressing on the appropri­ate and best palpated interspace about an hour before surgery facilitates painless lumbar puncture without any additional parenteral sedation. EMLA should be used with caution in infants less than three months and those receiving any methemoglobin inducing drugs like sul­fonamides, phenytoin, phenobarbital, acetaminophen. [12] Intraoperatively, sedation can be augmented with midazolam upto 0.1mg.kg -1 . Flavoured pacifiers for young and music or books for older children may be used in case the child is awake and cooperative.

The needles available for paediatric use range from 24-29 G, either short bevelled Quincke or Sprotte and Whitacre with or without introducer with a length shorter than that in adults. If specialised needles are unavail­able or their cost is prohibitive, even hypodermic needle or the metal stillete of a small gauge intravenous can­nula can be used without much difficulty. Correct place­ment of the needle is ascertained by free flow of CSF. Some of the needles also have a magnifier hub for fast recognition of flashback of CSF. The child may be kept in the dependent side for a few minutes for lateralisation of the block. A successful block usually takes about 2­5 mins and care should be taken that the leg is not lifted just after the block for placement of diathermy pads which often results in undesired cephalad spread of the block.

The extent of the sensory block can be checked by pin-prick or skin pinch and that of the motor block by Bromage scale. [13] This may however be difficult to check in a deeply sedated child and can only be done in the postanesthesia care unit (PACU) to check the block regression. However, it can be clinically ascer­tained by lack of leg movement and diaphragmatic breathing. Children very often fall asleep with the de­afferentation following the block.

Intraoperative fluids only include deficit and main­tenance amounts and preload need not be given as in adults. The hypotensive cardiovascular response to sympathectomy is minimal or none in children. How­ever, standard monitoring is mandatory and oxygen by face mask is recommended in all cases.

All patients should be monitored in the PACU for vital signs, two-segment block regression, pain and any other side effect. Children should only be discharged when they are awake and able to walk unaided, the vital signs are stable for at least 1 h, there is no pain, nausea/retching or vomiting, and are able to tolerate clear fluids.


   Intrathecal drugs Top


Among the various drugs approved by FDA for paediatric intrathecal use, 0.5% bupivacaine and ropivacaine are common and popular. The doses used are institutional though the standard protocol that I have been practicing is 0.5% bupivacaine 0.1ml.kg -1 or 0.5mg.kg -1 for infants weighing 0-5 Kg; 0.08ml.Kg -1 or 0.4mg.kg -1 for 5-15Kg body weight and 0.06ml.kg­1 or 0.3mg.kg -1 for >15 Kg weight. [6]

Levobupivacaine has very similar PH) arma­cokinetic properties to those of racemic bupiva-caine, but the potential for toxicity with levobupivacaine is less. Kokki et al performed a study on 40 children, aged 1- 14 yr, undergoing elective lower abdominal or lower limb surgery levobupivacaine 5 mg.mL -1 at a mean dose of 0.3 mg.kg 1 body weight, and found equivalent clini­cal efficacy in spinal anaesthesia in children to that of racemic bupivacaine. [14],[15]

Ropivacaine 5mg.ml -1 has also been used in some studies and found to be effective and safe in isobaric form. In a study of 93 children 1-17 years of age, Kokki H et al used 0.5mg.kg -1 (upto 20mg) in lateral decubi­tus position and achieved good block performance. [16]

Baricity is one of the most significant factors to affect the distribution of the local anaesthetic and hence success and spread of the blockade. The effect of dif­fering degrees of hyperbaricity was evaluated by sev­eral workers in paediatric age group. It is not known whether hyperbaric local anaesthetic is better than iso­baric in children in contrast to adults where it is proven to be more reliable, safe and effective. [17] Isobaric bupivacaine has also been used for spinal anaesthesia in children and compared with its hyperbaric form. Kokki H [18] compared bupivacaine 5 mg.ml -1 , isobaric in saline 0.9% and hyperbaric in 8% glucose, for spinal anaesthesia in 100 children, aged 2-115 months for paediatric day case surgery. The success rate of the block was greater with hyperbaric bupivacaine (96%) compared with isobaric bupivacaine (82%). Intense motor block was associated with adequate sensory block. Spread and duration of sensory block showed a similar wide scatter in both groups. Cardiovascular stability was good in both groups. The study gave an impression of a delayed onset time of spinal block, as most of the nine children who required either fentanyl or a sedative for a mild reaction to skin incision had complete block when transferred to the recovery room after operation.

However, in an article published two years later the same authors, Kokki H et al demonstrated that bupivacaine in 0.9% glucose and in 8% glucose solu­tions are equally suitable for spinal anaesthesia in small children. Similar success rate, spread and duration of the sensory and motor block are achieved with both baricities of bupivacaine. [19]

Various studies have been done with child in lat­eral or sitting position for a subarachnoid block. In a study on 30 preterm infants for inguinal herniotomy, Vila et al found spinal anaesthesia to be equally effective in both lateral and sitting position. [20]

Duration is an important and a limiting factor for paediatric spinal anaesthesia especially in infants and younger children. Spinal anaesthesia alone for this rea­son is therefore generally restricted to one hour dura­tion surgeries only. The duration is longer with larger doses in infants and varies directly with the age of the child. It has been seen that the duration of long acting local anaesthetics like bupivacaine is only about 45 min in neonates and 75-90 min in children upto five years. There is no difference in duration by adding epineph­rine to bupivacaine.


   Additives Top


Since the duration of spinal anaesthesia does not cover most of the postoperative period, it is essential to add intravenous or rectal acetaminophen or ketoprofen routinely to all patients. Profound postop­erative analgesia can be achieved by adding a low dose local anaesthetic with or without an opioid (fentanyl), clonidine 1-2µg.kg -1 or any other additive in caudal space at the time of performing the subarachnoid block. A caudal catheter can also be placed and local anaes­thetic plus opioid added for prolonged analgesia post­operatively.


   Complications Top


The complications related to spinal anaesthesia are usually either due to the needle used to perform the procedure (backache, headache, nerve or vascular in­jury and infection) or the drugs injected (high or total spinal, drug toxicity). However, little data is available regarding the incidence as compared to adults.

Post dural puncture headache (PDPH) is rare in paediatric patients and some authors have even chal­lenged its existence. In his study on 200 children using two different sizes spinal needles of 25 G and 29 G Quinke, Kokki et al [21] found that 10 had PDPH with no difference regarding the type of needle used. The failure rate of attempted spinal anaesthesia was 4% and even when the subarachnoid space was reached and the local anaesthetic injected, the overall success rate of the technique was only 91%.

Transient neurological symptom (TNS) has been reported by some authors following spinal anaesthesia due to direct toxicity of large doses of local anaesthetics. In his study on 95 patients using 0.5% isobaric ropivacaine, Kokki et al [16] reported mild to moderate TNS in four children which was transient and was not followed by any permanent neurological sequelae. In another study by the same author similar results were found with 0.5% bupivacaine. [17]

A one year study of 24,409 regional blocks in children by the French-Language Society of Pediatric Anesthesiologists, [22] the largest known study on com­plications, revealed a complication rate of 1.5 per 1000 in the 60% of children receiving central neuraxial blocks. However, most of these cases were those of caudal and some of epidural technique.


   Advantages Top


Spinal anaesthesia produces a reliable, profound and uniformly distributed sensory block with rapid on­set and good muscle relaxation, and it results in more complete control of cardiovascular and stress responses than epidural or opioid anaesthesia. [23] It is ideal for day­case surgeries and is safe and cost-effective. There is no additional requirement of any special drug or equip­ment for the procedure. Because of these benefits, spi­nal anaesthesia has gained acceptance for children un­dergoing surgery in the lower part of the body. [24]




   Comparison with general anaesthesia Top


General anaesthesia may be associated with sev­eral life-threatening complications especially in preterm, former preterm, those with co-morbidities like sepsis, necrotising enterocolitis, anaemia (hematocrit<30%), severe respiratory disease like respiratory distress syn­drome, bronchopulmonary dysplasias, cystic fibrosis etc. All these neonates are at much higher risk of ap­noea, bradycardia and desaturation after general ana­esthesia. [9] Spinal anaesthesia is a safe, reliable and simple technique in a high risk infant. In 1984, Abajian et al sparked an interest in this group and since then all the reports have ascertained this fact. [24]

In the healthy children, most of the procedures are performed as day-case surgeries like herniotomy, circumcision, minor urological and orthopaedic proce­dures. Spinal anaesthesia is a very good alternative for such cases were the child can be returned to the family and a lot of stress to the parents is avoided. Since less general anaesthetic drugs including parenteral opioids are used, the risk of postoperative respiratory depres­sion is minimal. The stress response to surgery is also limited and recovery is fast.

Kokki et al studied 100 children for paediatric day-case surgery and found the technique safe and ef­fective. [18] In his 10 years of experience of paediatric orthopaedic surgery, Bang-Vojdanovski B concluded that spinal anaesthesia is a suitable anaesthetic tech­nique for paediatric surgery. [25] This method of anaes­thesia may avoid the increased incidence of postop­erative respiratory complications associated with gen­eral anaesthesia.

Intraoperative laryngo and bronchospasm are not uncommon even in healthy infants and children besides episodes of coughing, breath-holding, endotracheal tube obstruction and atelectasis. Moreover, with the increas­ing incidence of upper respiratory infections, commonly 3-8 times in a year in paediatric age group there will always be a risk of a hyper-reactive airway under gen­eral anaesthesia. Besides, there are no preoperative tests feasible which would rule out any mild-moderate respiratory infection in children. Most of the times, the clinician has to rely only on the history provided by the parents. More commonly the symptoms appear only on the day of surgery and it becomes a difficult deci­sion to cancel the surgery. Spinal anaesthesia is rela­tively safer in all these instances where spontaneous airway can be maintained by the patient.

Kokki et al also conducted a study on forty chil­dren, age 2-5 years undergoing paediatric surgery and compared spinal with general anaesthesia. [26] Time spent in the operation room was shorter in the spinal anaes­thesia group because the children were awake and could immediately be transferred. The haemodynamic pat­tern and respiratory function were stable during spinal anaesthesia. Arterial desaturation (< 90%), vomiting, sore throat and micturition difficulties were the adverse events associated with general anaesthesia. Three pa­tients were restless after spinal anaesthesia.

In a study of 30 cases aged 7 months to 13 years at the Children's National Medical Centre, Washing­ton, open heart surgery was performed under high sub­arachnoid block along with light general anaesthesia by Finkel JC et al and haemodynamic stability was found to be maintained intra operatively in all cases. [10]

Spinal anaesthesia has been found to be more cost effective as compared to general anaesthesia. The drugs and equipment required are much less and cheaper be­sides the length of hospital stay which is also usually shorter. [27]

Paediatric spinal anaesthesia may have been con­ceptualized a century ago but its golden years are yet to come. Overall patient safety, feasibility and reliabil­ity are the key features of this technique which will only become better with greater use, experience and re­search.

 
   References Top

1.Gray HT. A study of spinal anesthesia in children and infants from a series of 200 cases. I Lancet 1909; 2:913-916.  Back to cited text no. 1      
2.Gray HT. A study of spinal anesthesia in children and infants from a series of 200 cases. II Lancet 1909; 2:991-994.  Back to cited text no. 2      
3.Gray HT. A study of spinal anesthesia in children and infants from a series of 200 cases. III Lancet 1910; 1:1611-1615.  Back to cited text no. 3      
4.Bainbridge WS. A report of twelve operations on infants and young children during spinal anesthesia. Arch, Pediatr 1901; 18:570-574.  Back to cited text no. 4      
5.Jo Rice L, Brilton J. Anestesia Raqui za Neonatal. Cli.Anest de N.A.1992; 1:135-136.  Back to cited text no. 5      
6.Dalens Bernard J. Regional Anesthesia in children. In: Miller RD (Ed.). Anesthesia, 6th ed. New York: Churchill Livingstone Inc 2005: 1719-1762.  Back to cited text no. 6      
7.Sethna N F, Berde CB. Pediatric Regional Anesthesia. In: Gregory GA (Ed.). Pediatric Anesthesia, 4 th ed. New York: Churchill Livingstone Inc, 2002: 267-316.  Back to cited text no. 7      
8.Finster M. Toxicity of local anesthetics in the fetus and newborn. Bull NY Acad Med1976; 52:222-5.  Back to cited text no. 8      
9.Cote CJ, Zaslavsky A, Downes JJ. Postoperative apnoea in former preterm infants after inguinal herniorrhaphy. Anesthesiology 1995; 82:809-812.  Back to cited text no. 9      
10.Finkel JC, Boltz MG, Conran AM. Haemodynamic changes during high spinal anaesthesia in children having open heart surgery. Paediatr Anaesth 2003; 13:48-52.  Back to cited text no. 10  [PUBMED]  [FULLTEXT]  
11.Cravero JP, Blike GT. Review of pediatric sedation. Anesth Analg 2004; 99:1355-64.  Back to cited text no. 11  [PUBMED]  [FULLTEXT]  
12.Gourrier E, Karoubi P. Use of EMLA cream in a depart­ment of neonatology. Pain 1996; 68:431-434.  Back to cited text no. 12      
13.Bromage PR. A comparison of the hydrochloride and car­bon dioxide salts of lidocaine and prilocaine in epidural analgesia. Acta Anaesthesiol Scand 1965; 16:55-69.  Back to cited text no. 13      
14.Hannu Kokki, Paula Ylonen. Levobupivacaine for Pedi­atric Spinal Anesthesia. Anesth Analg 2004; 98:64-67.  Back to cited text no. 14      
15.Foster RH, Markham A. Levobupivacaine: a review of its pharmacology and use as a local anaesthetic. Drugs 2000; 59: 551-9.  Back to cited text no. 15  [PUBMED]  [FULLTEXT]  
16.Hannu Kokki, Paula Ylo¨nen, Merja Laisalmi. Isobaric Ropivacaine 5 mg/mL for Spinal Anesthesia in Children. Anesth Analg 2005; 100:66 -70.  Back to cited text no. 16      
17.Kokki H. Spinal anesthesia in infants and children. Best Pract Res Clin Anesthesiol 2000; 14:687-707.  Back to cited text no. 17      
18.Kokki H, Tuovinen K, Hendolin H. Spinal anaesthesia for paediatric day-case surgery: a double-blind, random­ized, parallel group, prospective comparison of isobaric and hyperbaric bupivacaine. Br J Anaesth 1998; 81:502­6.  Back to cited text no. 18  [PUBMED]  [FULLTEXT]  
19.Kokki H, Hendolin H. No difference between bupivacaine in 0.9% and 8% glucose for spinal anaesthesia in small children. Acta Anaesthesiol Scand 2000; 44:548-51.  Back to cited text no. 19  [PUBMED]  [FULLTEXT]  
20.Vila, R, Lloret, J, Munar, F. Spinal anaesthesia for in­guinal herniotomy in preterm infants sedated with ni­trous oxide: a comparison of lumbar puncture in the lat­eral or sitting position. Anaesthesia 2002; 57:1164-1167.  Back to cited text no. 20      
21.Kokki H, Hendolin H. Comparison of 25 G and 29 G Quincke spinal needles in paediatric day case surgery. A prospective randomized study of the puncture charac­teristics, success rate and postoperative complaints. Paediatr Anaesth 1996; 6:115-119.  Back to cited text no. 21  [PUBMED]    
22.Glaufre E, Dalens B, Gombert A. Epidemiology and mor­bidity of regional anesthesia in children: a one year pro­spective study of the French-Language Society of Pedi­atric Anesthesiologists. Anesth Analg 1996; 83: 904-12.  Back to cited text no. 22      
23.Wolf AR, Doyle E, Thomas E. Modifying infant stress responses to major surgery: spinal vs extradural vs opioid analgesia. Paediatr Anaesth 1998; 8:305-11.  Back to cited text no. 23  [PUBMED]  [FULLTEXT]  
24.Abajian C, Paul Mellish RW. Spinal anesthesia for sur­gery in high risk infant. Anesth Analg 1984; 63: 359-62.  Back to cited text no. 24      
25.Bang Vojdanovski B. 10 years of spinal anesthesia in infants and children for orthopedic surgery. Our clinical experience. Anaesthesist 1996; 45:271-7.  Back to cited text no. 25      
26.Kokki H, Hendolin H, Vainio J, Partanen J. Pediatric sur­gery. A comparison of spinal anesthesia and general an­esthesia. Anaesthesist 1992; 41:765-8.  Back to cited text no. 26  [PUBMED]    
27.Carlos C, Melvin E. First 300 Cases of Pediatric Regional Anesthesia in Venezuela (Caudal, Spinal And Peridural). The Internet Journal of Anesthesiology 2000;4:4-10.  Back to cited text no. 27      




 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
    Introduction
    Anatomical and p...
    Pharmacology
    Indications
    Contraindications
    Consent and risk...
    NPO and premedic...
    Procedure, needl...
    Intrathecal drugs
    Additives
    Complications
    Advantages
    Comparison with ...
    References

 Article Access Statistics
    Viewed16971    
    Printed143    
    Emailed5    
    PDF Downloaded2640    
    Comments [Add]    

Recommend this journal