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REVIEW ARTICLE
Year : 2009  |  Volume : 53  |  Issue : 3  |  Page : 281-293

The Microcirculation in Sepsis


1 Reader, Department of Anaesthesiology & Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Shahadra, Delhi-110095, India
2 Professor & Head, Department of Anaesthesiology & Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Shahadra, Delhi-110095, India
3 Senior Resident, Department of Anaesthesiology & Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Shahadra, Delhi-110095, India

Correspondence Address:
Asha Tyagi
103, Siddhartha Enclave, New Delhi-14
India
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Source of Support: None, Conflict of Interest: None


PMID: 20640135

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Sepsis is a leading cause of mortality in critically ill patients. The pathophysiology of sepsis involves a highly complex and integrated response, including the activation of various cell types, inflammatory mediators, and the haemostatic system. Recent evidence suggests an emerging role ofthe microcirculation in sepsis, necessitating a shift in our locus away Irom the macrohaemodynamics to ill icrohaemodynanmics in a septic patient. This review article provides a brief overview of the microcirculation, its assessment techniques, and specific therapies to resuscitate the microhaemodynamics.


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