Indian Journal of Anaesthesia  
About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions
Home | Login  | Users Online: 236  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size    


CLINICAL INVESTIGATIONS
Year : 2009  |  Volume : 53  |  Issue : 6  |  Page : 662-666

Comparison of Midazolam and Propofol for BIS-Guided Sedation During Regional Anaesthesia


1 Ex.P.G.Student, Deptt. Of Anaesthesiology, BHU, Varanasi, India
2 Sr.Resident, Deptt. Of Anaesthesiology, BHU, Varanasi, India
3 Reader, Deptt. Of Anaesthesiology, BHU, Varanasi, India
4 Professor, Deptt. Of Anaesthesiology, BHU, Varanasi, India

Correspondence Address:
Ankit Agarwal
Sr.Resident, Deptt. Of Anaesthesiology, BHU, Varanasi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 20640093

Rights and PermissionsRights and Permissions

Regional anaesthesia has become an important anaesthetic technique. Effective sedation is an essential for regional techniques too. This study compares midazolam and propofol in terms of onset& recovery from sedation, dosage and side effects of both the drugs using Bispectral Index monitoring. Ninety eight patients were randomly divided into two groups,one group recieved midazolam infusion while the other recieved propofol infusion until BIS reached 75. We observed Time to reach desired sedation, HR, MABP, time for recovery, dose to reach sedation and for maintenance of sedation and side effects if any. The time to reach required sedation was 11 min in Midazolam group(Group I) while it was 6 min in Propofol group(Group II) (p=0.0). Fall in MABP was greater with propofol. Recovery in with midazolam was slower than with propofol (18.6 ± 6.5 vs 10.10±3.65 min) (p=0.00). We concluded that both midazolam and propofol are effective sedatives, but onset and offset was quicker with propofol, while midazolam was more cardiostable.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1955    
    Printed96    
    Emailed1    
    PDF Downloaded514    
    Comments [Add]    

Recommend this journal