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CLINICAL INVESTIGATIONS
Year : 2009  |  Volume : 53  |  Issue : 6  |  Page : 667-671

Efficacy and Safety of Tranexamic Acid in Control of Bleeding Following TKR: A Randomized Clinical Trial


1 Head of the Department of Anesthesia, Fortis Hospital, Shalimar Bagh, New Delhi, India
2 Attending Consultant, Department of Anesthesiology and Pain Management, Max Super specialty Hospital, Saket, New Delhi. 110017, India
3 Associate consultant, Department of Anesthesiology and Pain Management, Max Super specialty Hospital, Saket, New Delhi. 110017, India
4 Ex Senior resident, Department of Anesthesiology and Pain Management, Max Super specialty Hospital, Saket, New Delhi. 110017, India

Correspondence Address:
P N Kakar
B - 8, Sushant Lok, Phase II, Golf Course Road, Sector - 56, Gurgaon
India
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Source of Support: None, Conflict of Interest: None


PMID: 20640094

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Total knee arthroplasty (TKA) is generally carried out using a tourniquet and blood loss occurring mainly post operatively is collected in drains. Tranexamic acid is an antifibrinolytic agent which decreases the total blood loss. Patients had unilateral / bilateral cemented TKA using combined spinal and epidural anaesthesia. In a double-blind fashion, they received either placebo (n=25) or tranexamic acid (n=25)10 mg.kg -1 i.v., just before tourniquet inflation, followed by 1 mg kg -1 h -1 i.v. till closure of the wound. The postoperative blood loss, transfusion requirement, cost effectiveness and complications were noted. The groups had similar characteristics. The mean volume of drainage fluid was 270 ml and 620 ml for unilateral(U/L) and bilateral(B/L) TKR patients in placebo group. Whereas it was 160ml and 286 ml respectively in unilateral(U/L) and bilateral(B/L) TKR patients who received tranexamic acid. This was considered statistically significant. Control group patients received 26 units of PRBC as compared to 4 units in tranexamic acid groups (p<0.001). This was again statistically significant. None of the patients in any of the groups developed deep vein thrombosis. Tranexamic acid decreased total blood loss by nearly 54% in B/L TKR and 40% in U/L TKR and drastically reduced (> 80%) blood transfusion.


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