Indian Journal of Anaesthesia  
About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions
Home | Login  | Users Online: 646  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size    




 
REVIEW ARTICLE
Year : 2010  |  Volume : 54  |  Issue : 5  |  Page : 428-438 Table of Contents     

Neonatal resuscitation: Current issues


Department of Anaesthesiology, B J Medical College, Ahmedabad - 38 0016, India

Date of Web Publication9-Oct-2010

Correspondence Address:
Indu A Chadha
K-104, Shilalekh Apartments, Opposite Police Stadium Shahibaug, Ahmedabad - 380 004
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5049.71042

Rights and Permissions
 

The following guidelines are intended for practitioners responsible for resuscitating neonates. They apply primarily to neonates undergoing transition from intrauterine to extrauterine life. The updated guidelines on Neonatal Resuscitation have assimilated the latest evidence in neonatal resuscitation. Important changes with regard to the old guidelines and recommendations for daily practice are provided. Current controversial issues concerning neonatal resuscitation are reviewed and argued in the context of the ILCOR 2005 consensus.

Keywords: Current issues, guidelines, neonatal resuscitation, resuscitation


How to cite this article:
Chadha IA. Neonatal resuscitation: Current issues. Indian J Anaesth 2010;54:428-38

How to cite this URL:
Chadha IA. Neonatal resuscitation: Current issues. Indian J Anaesth [serial online] 2010 [cited 2017 Apr 29];54:428-38. Available from: http://www.ijaweb.org/text.asp?2010/54/5/428/71042


   Introduction Top


Neonatal Asphyxia accounts for 20.9% of neonatal deaths. Although the vast majority of newly born infants (90%) do not require intervention to breathe during transition from intrauterine to extrauterine life, approximately 10% of the newborns require some assistance to begin breathing at birth, and about 1% require extensive resuscitative measures. [1],[2],[3]

The goals of neonatal resuscitation are to prevent the morbidity and mortality associated with hypoxic-ischaemic tissue (brain, heart, kidney) injury and also to re-establish adequate spontaneous respiration and cardiac output. [2],[3]

Guidelines for neonatal resuscitation have been issued by the American Heart Association and the American Academy of Paediatrics. The guidelines are helpful in remembering the sequence for resuscitation. Failure to follow the guidelines has resulted in bad outcomes. [1],[2]

A rapid assessment of newly born infants who do not require resuscitation can generally be identified by the following four characteristics:

  1. Was the infant born after a full-term gestation?
  2. Is the amniotic fluid clear of meconium and evidence of infection?
  3. Is the infant breathing or crying?
  4. Does the infant have good muscle tone?
If the answer to all four of these questions is 'yes,' the infant does not need resuscitation and should not be separated from the mother. The infant can be dried, placed directly on the mother's chest and covered with dry linen, to maintain temperature. Observation of breathing, activity and colour should be ongoing.

If the answer to any of these assessment questions is 'no,' there is a general agreement that the infant should receive one or more of the following four categories of action in sequence:

  1. Initial steps in stabilisation (provide warmth, position, clear airway, dry, stimulate, re-position)
  2. Ventilation
  3. Chest compressions
  4. Administration of epinephrine and / or volume expansion
The decision to progress from one category to the next is determined by the simultaneous assessment of three vital signs: respiration, heart rate and colour. Approximately 30 seconds is allotted to complete each step, re-evaluate and decide whether to progress to the next step [1],[2],[3],[4] [Figure 1].
Figure 1: Neonatal flow algorithm (Neonatal Resuscitation Guidelines, Circulation, 2005)

Click here to view



   Initial Steps Top


The initial steps of resuscitation are to provide warmth by placing the infant under a radiant heat source, position the head in a 'sniffing' position to open the airway, clear the airway with a bulb syringe or suction catheter, dry the infant and stimulate breathing. Evaluation of the neonate for respiration, heart rate and colour at every 30-second interval must be done [1],[2],[3],[4],[5],[6],[7] [Figure 1].

During delivery, if the amniotic fluid is meconium stained:

  1. If the baby is vigorous (strong respiratory effort i.e., cry, good muscle tone, heart rate > 100 bpm) at birth, clear the airway by suctioning mouth first and then the nose with a bulb syringe or suction catheter. If bradycardia occurs during suctioning then stop suctioning and re-evaluate the heart rate. No intubation suctioning is required.
  2. If the baby is not vigorous (depressed respiration, depressed muscle tone and heart rate < 100 bpm), the newborn requires tracheal suctioning. First insert a laryngoscope and clear the mouth and posterior pharynx by using a suction catheter under direct vision, then insert the endotracheal tube into the trachea. Attach a suction device to the endotracheal tube. Apply suction as the tube is slowly withdrawn. Repeat if necessary till the meconium is recovered or until the heart rate indicates < 60 bpm, after which resuscitation must proceed without delay. A gentle but firm stimulation is given; gently flick the soles and rub the back.
  3. If heart rate is low, that is, < 100 bpm, positive pressure ventilation (PPV) should be provided without suctioning of the trachea.
  4. If the newborn is breathing and pink and has a heart rate >100 bpm, observe him.
  5. If the newborn is not breathing and remains apnoeic or gasping, has a heart rate of < 100 bpm or appears blue, the next step is to assist the neonate's breathing by positive pressure ventilation, and if he is cyanotic supplemental oxygen is to be given.
  6. After about 30 seconds of ventilation and / or supplemental oxygen, evaluation is done again.
  7. If the newborn starts breathing, becomes pink and has a heart rate of > 100 bpm, post resuscitation care must be given.
  8. If heart rate is > 60 bpm, then support of the circulation by chest compression and positive pressure ventilation must be continued till the heart rate reaches > 100 bpm and the newborn becomes pink.
  9. If the heart rate is < 60 bpm, then support of the circulation by chest compression and positive pressure ventilation must be done. After about 30 seconds, evaluation is done again.
  10. If the heart rate is still < 60 bpm then epinephrine is administered along with continued PPV and chest compression. If the heart rate remains < 60 bpm, chest compression, positive pressure ventilation, and epinephrine can be repeated every three to five minutes.
  11. In case of placental abrupt, placenta previa or blood loss from the umbilical cord, the baby may not improve despite effective ventilation, chest compression and epinephrine. The baby will look pale, have delayed capillary refill, weak pulse and a low heart rate. The baby may be in hypovolemic shock and will need volume support.


The above guidelines are to be followed during every delivery of a newborn.

Although the Apgar score is a simple useful guide to neonatal well-being and resuscitation, it is only a guide. It is useful to convey the information about a newborn's overall status and response to resuscitation at the time points, during resuscitation. The one minute score correlates well with acidosis and survival. The five minute score may or may not be predictive of the neurological outcome. [6],[7],[8],[9],[10],[11]

In every delivery room, an area should be allotted for neonatal resuscitation, with all the necessary equipment and drugs stored nearby [Table 1]. During every delivery there should be at least one person whose primary responsibility is the new born. This person must be capable of initiating resuscitation, including administration of positive-pressure ventilation and chest compression. [1],[3]
Table 1: Neonatal resuscitation supplies and equipment

Click here to view


In high-risk births, the majority of newborns requiring resuscitation can be identified before birth. If need for resuscitation is anticipated, additional skilled personnel should be recruited and the necessary equipment prepared. A team of skilled personnel are required at the delivery of the baby - one for position suctioning and drying, and others for airway and endotracheal intubation, and a fourth for medication. [1].[2].[3] If a pre-term delivery (< 37 weeks of gestation) is expected, special preparations will be required.


   Special Situations Top


Conditions like Choanal atresia, pharyngeal airway malformations, laryngeal web, pneumothorax, plural effusion and Diaphramatic hernia should be looked for. Those requiring immediate interventions like putting an airway in the mouth for patency of neonates' airway, by nasopharyngeal airway, tracheotomy or by insertion of intercostal drains must be done. [1],[2],[3],[4]


   Post-Resuscitation Care Top


Infants who require resuscitation are at risk of deterioration after their vital signs have returned to normal. Once adequate ventilation and circulation have been established, the infant should be maintained in or transferred to an environment in which close monitoring and anticipatory care can be provided. [1],[2],[3],[4]


   Guidelines for Withholding and Discontinuing Resuscitation Top


Morbidity and mortality for newborns vary according to the region and availability of resources. [2]

1. Withholding resuscitation

For conditions associated with high mortality and poor outcome, withholding resuscitative efforts may be considered, particularly when there has been parental agreement. [2],[11],[12] A consistent and coordinated approach to individual cases by the obstetric and neonatal teams and the parents is an important goal. [2],[10],[12]

Non-initiation of resuscitation and discontinuation of life-sustaining treatment during or after resuscitation are ethically equivalent, and clinicians should not hesitate to withdraw support with no functional survival. The following guidelines must be interpreted: [2],[11]

  1. When gestation, birth weight or congenital anomalies are associated with certain early death and unacceptably high morbidity, resuscitation is not indicated, for example, extreme prematurity (gestational age < 23 weeks or birth weight < 400 g), anencephaly or chromosomal abnormalities, such as trisomy 13.
  2. In conditions with a high rate of survival and acceptable morbidity, resuscitation is nearly always indicated, for example, infant with gestational age 25 weeks and infant with congenital malformations.
  3. In conditions associated with uncertain prognosis, wherein survival is borderline, the morbidity rate is high and the anticipated burden to the child is high, parental desires concerning initiation of resuscitation should be supported.
2. Discontinuing resuscitative efforts

Infants without signs of life (no heart beat and no respiratory effort) after 10 minutes of resuscitation show either a high mortality or severe neuro-developmental disability. [11],[12],[13] Therefore, after 10 minutes of continuous and adequate resuscitative efforts, discontinuation of resuscitation may be justified. [11],[12],[13]


   Current Issues Top


Temperature control

For the full-term newborn both standard thermal care (removing wet blankets, prompt drying, warming pads, wrapping the infant in a warm blanket, placing the infant skin-to-skin with the mother and covering both with a blanket) and placing the dried infant under a radiant heater are effective in maintaining normal body temperature. [14],[15] Several trials have shown that, in addition to radiant heating, covering premature infants up to the neck in a transparent plastic wrapping (heat-resistant, food-grade) without previous drying, results in a higher body temperature of the newborn at admission, especially in infants < 28 weeks' gestation. [14],[16],[17],[18],[19] Only the head is dried and covered with a cap. All resuscitation procedures, including intubation, chest compressions, and insertion of (central) lines, can be performed with the plastic cover in place. Currently, there is no evidence that this procedure improves mortality or the long-term outcome. Monitoring of body temperature should be considered, especially when resuscitation is prolonged, to avoid the small risk of inducing hyperthermia. [17],[19],[20]

Infants born to febrile mothers have been reported to have a higher incidence of perinatal respiratory depression, neonatal seizures, cerebral palsy and increased risk of mortality. [21],[22],[23],[24] Hyperthermia should be avoided. The goal is to achieve normothermia and avoid iatrogenic hyperthermia.

Clearing the airway of meconium

Aspiration of meconium before delivery, during birth or during resuscitation can cause severe meconium aspiration pneumonia (MAS) in 2 - 9% of the newborn infants. [25] One obstetrical technique, to try to decrease aspiration has been to suction the meconium from the infant's airway after delivery of the head, but before delivery of the shoulders (intrapartum suctioning). Studies suggest that intrapartum suctioning may be effective for decreasing the risk of the aspiration syndrome, [26],[27],[28] but evidence from a large trial did not show such an effect. [29] Therefore, current recommendations no longer advise routine intrapartum oropharyngeal and nasopharyngeal suctioning. In the case of meconium-stained amniotic fluid and a non-vigorous newborn, endotracheal suction by brief intubation or suction under direct vision is advised. If the infant is vigorous, endotracheal suction is not recommended, because it may cause harm and does not improve the outcome. [30]

Administration of oxygen

A normal newly born infant achieves and maintains pink mucous membranes without administration of supplementary oxygen. [31],[32] Continuous oximetry has shown that neonatal transition is a gradual process. [31],[32],[33] Healthy term newborns reach pre-ductal oxygen saturations, between 79 and 91%, 5 minutes after birth, [34] and it may take > 10 minutes to achieve a pre-ductal oxygen saturation of > 95% and nearly one hour to achieve post-ductal saturation of > 95%. [35],[36]

Newborns delivered by caesarean section and preterms reach average pre-ductal oxygen saturations of 90%, two minutes later than the healthy term newborns. [31],[32] There is concern about the potential adverse effects of 100% oxygen on the respiratory physiology, cerebral circulation, and tissue damage from oxygen-free radicals. Conversely, there is also concern about tissue damage from oxygen deprivation during and after asphyxia. Studies on blood pressure, cerebral perfusion, and various biochemical measures of cell damage in asphyxiated animals, resuscitated with 100% oxygen versus 21% oxygen (room air), have shown conflicting results. [37],[38],[39],[40],[41],[42] Study of preterm infants (< 33 weeks of gestation) exposed to 80% oxygen found lower cerebral blood flow when compared with those stabilized using 21% oxygen. [43] Meta-analysis studies showed a reduction in mortality rate and no harm in infants resuscitated in room air than with 100% oxygen. [44],[45]

Supplementary oxygen is recommended whenever positive-pressure ventilation is indicated for resuscitation; free-flow oxygen should be administered to infants who are breathing, but have central cyanosis. The standard approach for resuscitation is to use100% oxygen. Some clinicians may begin resuscitation with an oxygen concentration of less than 100% and some may start with room air. Both these practices during resuscitation of neonates are reasonable. If the clinician begins resuscitation with room air, supplementary oxygen must be available to use if there is no appreciable improvement within 90 seconds of the birth. In situations where supplementary oxygen is not readily available, positive-pressure ventilation should be administered with room air. Administration of a variable concentration of oxygen guided by pulse oximetry may improve the ability to achieve normoxia more quickly.

Initial breaths and assisted ventilation

In term infants, initial inflations - either spontaneous or assisted - create a functional residual capacity. [46],[47],[48],[49],[50] The optimum pressure, inflation time, and flow rate required to establish an effective functional residual capacity have not been determined.

Inflation breaths are used in newborn resuscitation, to facilitate the aeration of the fluid-filled lungs, by applying a higher airway pressure for a prolonged period of time. When a pressure of 30 cm H 2 O is applied for a duration of five seconds, a higher lung volume is achieved than in the conventional one-second inflations. [47] One trial in preterm newborns has shown that sustained initial inflations through a nasopharyngeal tube, followed by nasal Continuous Positive airway pressure (CPAP), reduces the need for intubation. [47] Although the evidence is based on a few studies, inflation breaths may have a positive effect on postnatal adaptation for newborns in need of resuscitation.

Usually, the average initial peak inflating pressures of 30 to 40 cm H 2 O successfully ventilate unresponsive term infants. [46],[48],[49],[50],[51] Assisted ventilation rates of 40 to 60 breaths per minute are commonly used, but the relative efficacy of various rates has not been investigated.

The primary measure of adequate initial ventilation is the prompt improvement in heart rate. Chest wall movement should be assessed if the heart rate does not improve. If inflation pressure is being monitored, an initial inflation pressure of 20 cm H 2 O may be effective, but 30 to 40 cm H 2 O may be required in some term infants without spontaneous ventilation. If pressure is not monitored, the minimum inflation required to achieve an increase in heart rate should be used. [52] There is insufficient evidence to recommend an optimum inflation time. In summary, assisted ventilation should be delivered at a rate of 40 to 60 breaths per minute, to promptly achieve or maintain a heart rate >100 bpm. The optimum pressure, inflation time and flow required to establish an effective Functional Residual Capacity (FRC) has not yet been determined.

Devices

Effective ventilation can be achieved with a self-inflating bag, flow-inflating bag or with a T-piece. [52],[53],[54] A T-piece is a valved mechanical device, designed to control flow and limit pressure. The pop-off valves of self-inflating bags are flow-dependent, and the pressures generated may exceed the value. [55] Target inflation pressures and long inspiratory times are more consistently achieved with a T-piece, rather than with bags, although the clinical implications are not clear. [56] To provide the desired pressure, healthcare providers need more training in the use of flow-inflating bags than with self-inflating bags. [57]

Laryngeal mask airways (LMAs) that fit over the laryngeal inlet have been shown to be effective for ventilating newly born near-term and full-term infants. [58],[59] There are limited data on the use of these devices in small preterm infants. [60],[61] The use of the LMA can provide effective ventilation in a time frame consistent with the current resuscitation guidelines, [59],[61],[62] although the infants studied were not being resuscitated. A controlled trial found no clinically significant difference between the use of the LMA and endotracheal intubation when the bag-mask ventilation was unsuccessful. [58] When the bag-mask ventilation has been unsuccessful and endotracheal intubation is not feasible or is unsuccessful, the LMA may provide effective ventilation. [63],[64],[65] There is insufficient evidence to support the routine use of the LMA as the primary airway device during neonatal resuscitation, in the setting of meconium-stained amniotic fluid, when chest compressions are required, in very low birth weight infants, or for delivery of emergency intra-tracheal medications. In the case of non-successful mask ventilation, where endotracheal intubation is not possible or problematic, a laryngeal mask should be considered as a good alternative. [66],[67]

Endotracheal tube placement

Endotracheal intubation may be indicated at several points during neonatal resuscitation:

  1. When tracheal suctioning for meconium is required
  2. If bag-mask ventilation is ineffective or prolonged
  3. When chest compressions are performed
  4. When endotracheal administration of medications is desired
For special resuscitation circumstances, such as congenital diaphragmatic hernia or extremely low birth weight (< 1000 g), the timing of endotracheal intubation may depend on the skill and experience of the providers.

After endotracheal intubation and administration of intermittent positive pressure, a prompt increase in heart rate is the best indicator that the tube is in the tracheobronchial tree and is providing effective ventilation. [6],[7],[8],[68] Exhaled CO 2 detection is effective for confirmation of endotracheal tube placement in infants and very low birth weight infants. [69],[70] Exhaled CO 2 detection is useful as a quick confirmation of the accurate position of the endotracheal tube, especially when clinical judgement is uncertain. [70],[71] A positive test result (detection of exhaled CO 2 ) in patients with adequate cardiac output confirms placement of the endotracheal tube within the trachea, whereas, a negative test result (i.e., no CO 2 detected) strongly suggests oesophageal intubation. [68],[69],[70],[71] Other clinical indicators of correct endotracheal tube placement are visual assessment during intubation, condensed humidified gas during exhalation, the presence or absence of chest movement and the confirmatory method after intubation, if the heart rate remains low and is not rising. These methods have to be systematically evaluated in neonates.

Chest compressions

Chest compressions are indicated for a heart rate that is < 60 bpm despite adequate ventilation with supplementary oxygen for 30 seconds. As ventilation is the most effective action in neonatal resuscitation and because chest compressions are likely to compete with effective ventilation, rescuers should ensure that assisted ventilation is being delivered optimally before starting chest compressions. Compressions should be delivered on the lower third of the sternum, [72],[73] to a depth of approximately one-third of the anterior-posterior diameter of the chest.

Two techniques have been described [Figure 2]:
Figure 2: Two methods of chest compression (Neonatal Resuscitation Guidelines, Circulation, 2005)

Click here to view


  1. Compression with two thumbs with fingers encircling the chest and supporting the back. [72],[73]
  2. Compression with two fingers with a second hand supporting the back.
The two-thumbs-encircling hands technique may generate higher peak systolic and coronary perfusion pressure than the two-finger technique. [74],[75] The two-thumb-encircling hands technique is recommended in newly born infants. However, the two-finger technique may be preferable when access to the umbilicus is required during insertion of an umbilical catheter.

Compressions and ventilations should be coordinated to avoid simultaneous delivery. The chest should be permitted to fully re-expand during relaxation, but the rescuer's thumbs should not leave the chest. There should be a 3:1 ratio of compressions to ventilations with 90 compressions and 30 breaths to achieve120 events per minute, to maximize ventilation at an achievable rate. [76] Thus, each event will be allotted approximately second. However, chest compressions are only effective if the lungs have first been successfully aerated, making the quality of the breaths and compressions more important than the rate.

Medications

Drugs are rarely indicated in resuscitation of the newly born infant. [77],[78] Bradycardia is usually because of inadequate lung inflation or profound hypoxemia, and establishing adequate ventilation is the most important step to correct it. [75] However, if the heart rate remains < 60 bpm despite adequate ventilation with 100% oxygen and chest compressions, administration of epinephrine or volume expansion, or both, may be indicated. Rarely are buffers, a narcotic antagonist or vasopressors useful after resuscitation.

Epinephrine

Past guidelines recommended that initial doses of epinephrine be given through an endotracheal tube because the dose can be administered more quickly than through the intravenous route. Animal studies showed a positive effect of endotracheal epinephrine, using higher doses than are currently recommended. [79],[80] However, the recommended doses of 0.01 or 0.03 mg/kg given endotracheally showed no effect. [81],[82],[83] Animal [82],[83],[84] and paediatric [84],[85] studies show exaggerated hypertension, decreased myocardial function and worse neurologic function after administration of higher doses (0.1 mg/kg) via IV. Therefore, IV administration of 0.01 to 0.03 mg/kg per dose is the preferred route, because the intravenous route in neonates can easily be achieved by inserting an umbilical venous catheter. While access is being obtained, a higher dose (0.1 mg/kg) through the endotracheal tube may be considered, but the safety and efficacy of this practice have not been evaluated. The concentration of epinephrine for either route should be 1:10000 (0.1 mg/ml). Observational studies in children and animals show no better outcome when high intravenous dosages are used. [83],[84],[85],[86] In addition, high intravenous dosages may increase the risk for intra-ventricular haemorrhage in preterm infants. Therefore, 0.01 - 0.03 mg/kg epinephrine is recommended via the intravenous route (via umbilical vein). The dosage can be repeated every one to three minutes.

Volume expansion

Volume expansion must be considered when blood loss is suspected or the infant appears to be in shock (pale skin, poor perfusion, weak pulse) and not responding to other resuscitative measures. An isotonic crystalloid rather than albumin is the solution of choice for volume expansion in the delivery room [87],[88],[89] The recommended dose is 10 ml/kg of normal saline, which can be repeated. In premature infants, giving volume expanders too rapidly must be avoided, because rapid infusions of large volumes can cause intra-ventricular haemorrhage. Emergency volume expansion may be accomplished with an isotonic crystalloid solution or O-negative red blood cells. Albumin-containing solutions are no longer the fluid for initial volume expansion. [87],[88],[89] Intraosseous access can serve as an alternative route for medications / volume expansion.

Naloxone

Naloxone is not a drug of choice as a part of initial resuscitative efforts in the delivery room for newborns with respiratory depression. If administration of naloxone is considered, heart rate and colour must first be restored by supporting ventilation. The preferred recommended route is IV or intra-muscular administration of naloxone. The recommended dose is 0.1 mg/kg, but no studies have examined the efficacy of this dose in newborns. Naloxone given to an infant born to an opioid-addicted mother has been associated with seizures. [90] Therefore, naloxone must be avoided in infants of mothers with opioid abuse. Naloxone is indicated in the infant for reversal of respiratory depression, secondary to maternal opioids, given four hours before delivery. Naloxone has a shorter half-life than the original maternal opioid. Therefore, the neonate must be monitored closely for recurrent apnoea or hypoventilation, and subsequent doses of naloxone may be required.

Glucose

Low blood glucose has been associated with an adverse neurologic outcome in a neonatal animal model of asphyxia and resuscitation. [91] Neonatal animals that were hypoglycemic at the time of an anoxic or hypoxic-ischaemic insult had larger areas of cerebral infarction or decreased survival, or both, when compared with the controls. One clinical study showed an association between hypoglycaemia and a poor neurologic outcome in perinatal asphyxia. [92]

The blood glucose concentration associated with the least brain injury after asphyxia and resuscitation cannot be defined based on the available evidence. Infants requiring resuscitation should be monitored and treated to maintain a normal glucose level; 50% Dextrose in a dose of 0.5 ml/kg may be given to correct hypoglycaemia.

Sodium bicarbonate

Use of sodium bicarbonate during resuscitation is controversial. It may be helpful to correct metabolic acidosis after a prolonged period of resuscitation. [81] However, it is harmful, particularly if given too early, as it mixes with acid and forms carbon dioxide. The lungs must be adequately ventilated to remove the carbon dioxide. The dose is 1 - 2 mEq / Kg / dose given as 4.2% solution (0.5 mEq/ml) at the rate of 1mEq / Kg / min.

Induced hypothermia

Studies are conflicting. One multicenter trial did not show a difference in the number of survivors with severe disabilities when head cooling was used. [93] Another large multicenter trial, along with a smaller trial that evaluated systemic hypothermia, found a significant decrease in death or moderate disability at age 12 months and 18 months. [94],[95],[96] A rapid increase in body temperature could cause hypotension. [97] Cooling to a core temperature of < 33΀C may cause arrhythmia, bleeding, thrombosis and sepsis, but studies have not reported these complications with modest hypothermia. [95],[96],[98] Avoidance of hyperthermia is particularly important in infants who may have had a hypoxic-ischaemic event.

There is insufficient data to recommend the routine use of modest systemic or selective cerebral hypothermia after resuscitation of infants with suspected asphyxia. Further clinical trials are needed to determine which infants benefit most and which method of cooling is most effective.


   Conclusion Top


Neonatal resuscitation contributes to a better care of newly born infants. Many important issues concerning neonatal resuscitation, have to be answered in the future, such as the effect of endotracheal suction in a meconium-stained, non-vigorous newborn, the outcome of preterm infants treated with occlusive plastic wrapping, the effect of inflation breaths with positive end-expiratory pressure on postnatal adaptation for newborns, the percentage and timing of additional oxygen in newborns not responding initially, the use of continuous positive airway pressure during neonatal resuscitation, the most efficacious intravenous dose of epinephrine in newborns with an asystole and the outcome of infants treated with hypothermia. In addition, implementation and training of the new guidelines in Neonatal Life Support Programmes will further contribute to the improvement in the care of newborn infants.

 
   References Top

1.2005 American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care (ECC) of pediatric and neonatal patients: neonatal resuscitation guidelines. Pediatrics 2006;117:e1029.  Back to cited text no. 1      
2.American Academy of Pediatrics. Overview and principles of resuscitation. In: Kattwinkel J, editor. Textbook of Neonatal Resuscitation. 5 th ed. Dallas, Tex.: American Academy of Pediatrics; 2006  Back to cited text no. 2      
3.American Academy of Pediatrics, American College of Obstetricians and Gynecologists. In: Gilstrap LC, Oh W, editors. Guidelines for Perinatal Care. 5 th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2002. p. 187.  Back to cited text no. 3      
4.International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Part 7: Neonatal resuscitation. Resuscitation 2005;67:293-303.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]  
5.Kamlin CO, O'Donnell CP, Everest NJ, Davis PG, Morley CJ. Accuracy of clinical assessment of infant heart rate in the delivery room. Resuscitation 2006;71:319-21.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]  
6.Owen CJ, Wyllie JP. Determination of heart rate in the baby at birth. Resuscitation 2004;60:213-7.  Back to cited text no. 6  [PUBMED]  [FULLTEXT]  
7.O'Donnell CP, Kamlin CO, Davis PG, Carlin JB, Morley CJ. Clinical assessment of infant colour at delivery. Arch Dis Child 2007;92:465-7.  Back to cited text no. 7      
8.American Academy of Pediatrics Committee on Fetus and Newborn; American College of Obstetricians and Gynecologists and Committee on Obstetric The Apgar score. Pediatrics 2006;117:1444-7.  Back to cited text no. 8      
9.Apgar V. A proposal for a new method of evaluation of the newborn infant. Curr Res Anesth Analg 1953;32:260-7.  Back to cited text no. 9  [PUBMED]    
10.Apgar V, Holaday DA, James LS, Weisbrot IM, Berrien C. Evaluation of the newborn infant; second report. J Am Med Assoc 1958;168:1985-8.  Back to cited text no. 10  [PUBMED]    
11.Draper ES, Manktelow B, Field DJ, James D. Tables for predicting survival for preterm births are updated. BMJ 2003;327:872.  Back to cited text no. 11      
12.Dahm LS, James LS. Newborn temperature and calculated heat loss in the delivery room. Pediatrics 1972;49:504-13.  Back to cited text no. 12  [PUBMED]    
13.Knobel RB, Vohra S, Lehmann CU. Heat loss prevention in the delivery room for preterm infants: a national survey of newborn intensive care units. J Perinatol 2005;25:514-8.  Back to cited text no. 13  [PUBMED]  [FULLTEXT]  
14.Costeloe K, Hennessy E, Gibson AT, Marlow N, Wilkinson AR. The EPICure study: outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics 2000;106:659-71.  Back to cited text no. 14  [PUBMED]  [FULLTEXT]  
15.Besch NJ, Perlstein PH, Edwards NK, Keenan WJ, Sutherland JM. The transparent baby bag. A shield against heat loss. N Engl J Med 1971;284:121-4.  Back to cited text no. 15  [PUBMED]  [FULLTEXT]  
16.Vohra S, Frent G, Campbell V, Abbott M, Whyte R. Effect of polyethylene occlusive skin wrapping on heat loss in very low birth weight infants at delivery: a randomized trial. J Pediatr 1999;134:547-51.  Back to cited text no. 16  [PUBMED]  [FULLTEXT]  
17.Vohra S, Roberts RS, Zhang B, Janes M, Schmidt B. Heat Loss Prevention (HeLP) in the delivery room: a randomized controlled trial of polyethylene occlusive skin wrapping in very preterm infants. J Pediatr 2004;145:750-3.  Back to cited text no. 17  [PUBMED]  [FULLTEXT]  
18.GS WHO. Thermal protection of the newborn; a practical guide, 2007.  Back to cited text no. 18      
19.Petrova A, Demissie K, Rhoads GG, Smulian JC, Marcella S, Ananth CV. Association of maternal fever during labor with neonatal and infant morbidity and mortality. Obstet Gynecol 2001;98:20-7.  Back to cited text no. 19  [PUBMED]    
20.Lieberman E, Lang J, Richardson DK, Frigoletto FD, Heffner LJ, Cohen A. Intrapartum maternal fever and neonatal outcome. Pediatrics 2000;105:8-13.  Back to cited text no. 20  [PUBMED]  [FULLTEXT]  
21.Grether JK, Nelson KB. Maternal infection and cerebral palsy in infants of normal birth weight. JAMA 1997;278:207-11.  Back to cited text no. 21  [PUBMED]    
22.Coimbra C, Boris-Moller F, Drake M, Wieloch T. Diminished neuronal damage in the rat brain by late treatment with the antipyretic drug dipyrone or cooling following cerebral ischemia. Acta Neuropathol (Berl) 1996;92:447-53.  Back to cited text no. 22      
23.Dietrich WD, Alonso O, Halley M, Busto R. Delayed posttraumatic brain hyperthermia worsens outcome after fluid percussion brain injury: a light and electron microscopic study in rats. Neurosurgery 1996;38:533-41.   Back to cited text no. 23  [PUBMED]  [FULLTEXT]  
24.Davis RO, Philips JB III, Harris BA Jr, Wilson ER, Huddleston JF. Fatal meconium aspiration syndrome occurring despite airway management considered appropriate. Am J Obstet Gynecol 1985;151:731-6.  Back to cited text no. 24      
25.Velaphi S, Vidyasagar D. Intrapartum and postdelivery management of infants born to mothers with meconium-stained amniotic fluid: evidence-based recommendations. Clin Perinatol 2006;33:29-42.  Back to cited text no. 25  [PUBMED]  [FULLTEXT]  
26.Carson BS, Losey RW, Bowes WA Jr, Simmons MA. Combined obstetric and pediatric approach to prevent meconium aspiration syndrome. Am J Obstet Gynecol 1976;126:712-5.  Back to cited text no. 26  [PUBMED]    
27.Falciglia HS, Henderschott C, Potter P, Helmchen R. Does DeLee suction at the perineum prevent meconium aspiration syndrome? Am J Obstet Gynecol 1992;167:1243-9.  Back to cited text no. 27  [PUBMED]    
28.Wiswell TE, Gannon CM, Jacob J, Goldsmith L, Szyld E, Weiss K, et al. Delivery room management of the apparently vigorous meconium-stained neonate: results of the multicenter, international collaborative trial. Pediatrics 2000;105:1-7.  Back to cited text no. 28  [PUBMED]  [FULLTEXT]  
29.Vain NE, Szyld EG, Prudent LM, Wiswell TE, Aguilar AM, Vivas NI. Oropharyngeal and nasopharyngeal suctioning of meconium-stained neonates before delivery of their shoulders: multicentre, randomised controlled trial. Lancet 2004;364:597-602.  Back to cited text no. 29  [PUBMED]  [FULLTEXT]  
30.Harris AP, Sendak MJ, Donham RT. Changes in arterial oxygen saturation immediately after birth in the human neonate. J Pediatr 1986;109:117-9.  Back to cited text no. 30  [PUBMED]    
31.Reddy VK, Holzman IR, Wedgwood JF. Pulse oximetry saturations in the first 6 hours of life in normal term infants. Clin Pediatr (Phila) 1999;38:87-92.  Back to cited text no. 31  [PUBMED]    
32.Toth B, Becker A, Seelbach-Gobel B. Oxygen saturation in healthy newborn infants immediately after birth measured by pulse oximetry. Arch Gynecol Obstet 2002;266:105-1.  Back to cited text no. 32      
33.Kamlin CO, O'Donnell CP, Davis PG, Morley CJ. Oxygen saturation in healthy infants immediately after birth. J Pediatr 2006;148:585-9.  Back to cited text no. 33  [PUBMED]    
34.O'Donnell CP, Kamlin CO, Davis PG, Carlin JB, Morley CJ. Clinical assessment of infant colour at delivery. Arch Dis Child 2007;92:465-7.  Back to cited text no. 34      
35.Owen CJ, Wyllie JP. Determination of heart rate in the baby at birth. Resuscitation 2004;60:213-7.  Back to cited text no. 35  [PUBMED]  [FULLTEXT]  
36.Huang CC, Yonetani M, Lajevardi N, Delivoria-Papadopoulos M, Wilson DF, Pastuszko A. Comparison of postasphyxial resuscitation with 100% and 21% oxygen on cortical oxygen pressure and striatal dopamine metabolism in newborn piglets. J Neurochem 1995;64:292-8.  Back to cited text no. 36  [PUBMED]  [FULLTEXT]  
37.Kutzsche S, Kirkeby OJ, Rise IR, Saugstad OD. Effects of hypoxia and reoxygenation with 21% and 100%-oxygen on cerebral nitric oxide concentration and microcirculation in newborn piglets. Biol Neonate 1999;76:153-67.  Back to cited text no. 37  [PUBMED]  [FULLTEXT]  
38.Solas AB, Kutzsche S, Vinje M, Saugstad OD. Cerebral hypoxemia-ischemia and reoxygenation with 21% or 100% oxygen in newborn piglets: effects on extracellular levels of excitatory amino acids and microcirculation. Pediatr Crit Care Med 2001;2:340-5.  Back to cited text no. 38  [PUBMED]  [FULLTEXT]  
39.Solas AB, Kalous P, Saugstad OD. Reoxygenation with 100 or 21% oxygen after cerebral hypoxemia-ischemia-hypercapnia in newborn piglets. Biol Neonate 2004;85:105-11.  Back to cited text no. 39  [PUBMED]  [FULLTEXT]  
40.Solas AB, Munkeby BH, Saugstad OD. Comparison of short- and long-duration oxygen treatment after cerebral asphyxia in newborn piglets. Pediatr Res 2004;56:125-31.  Back to cited text no. 40  [PUBMED]  [FULLTEXT]  
41.Lundstrom KE, Pryds O, Greisen G. Oxygen at birth and prolonged cerebral vasoconstriction in preterm infants. Arch Dis Child Fetal Neonatal Ed 1995;73:81-6.  Back to cited text no. 41      
42.Tan A, Schulze A, O'Donnell CP, Davis PG. Air versus oxygen for resuscitation of infants at birth. Cochrane Database Syst Rev 2005;2:CD002273.  Back to cited text no. 42  [PUBMED]  [FULLTEXT]  
43.Davis PG, Tan A, O'Donnell CP, Schulze A. Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis. Lancet 2004;364:1329-33.  Back to cited text no. 43  [PUBMED]  [FULLTEXT]  
44.Saugstad OD, Ramji S, Soll RF, Vento M. Resuscitation of newborn infants with 21% or 100% oxygen: an updated systematic review and meta-analysis. Neonatology 2008;94:176-82.  Back to cited text no. 44  [PUBMED]  [FULLTEXT]  
45.Vyas H, Milner AD, Hopkin IE, Boon AW. Physiologic responses to prolonged and slow-rise inflation in the resuscitation of the asphyxiated newborn infant. J Pediatr 1981;99:635-9.  Back to cited text no. 45  [PUBMED]    
46.Vyas H, Field D, Milner AD, Hopkin IE. Determinants of the first inspiratory volume and functional residual capacity at birth. Pediatr Pulmonol 1986;2:189-93.  Back to cited text no. 46  [PUBMED]    
47.Boon AW, Milner AD, Hopkin IE. Lung expansion, tidal exchange, and formation of the functional residual capacity during resuscitation of asphyxiated neonates. J Pediatr 1979;95:1031-6.  Back to cited text no. 47  [PUBMED]    
48.Hull D. Lung expansion and ventilation during resuscitation of asphyxiated newborn infants. J Pediatr 1969;75:47-58.  Back to cited text no. 48  [PUBMED]    
49.Upton CJ, Milner AD. Endotracheal resuscitation of neonates using a rebreathing bag. Arch Dis Child 1991;66:39-42.  Back to cited text no. 49  [PUBMED]  [FULLTEXT]  
50.Milner AD, Vyas H, Hopkin IE. Efficacy of facemask resuscitation at birth. BMJ 1984;289:1563-5.  Back to cited text no. 50  [PUBMED]  [FULLTEXT]  
51.Allwood AC, Madar RJ, Baumer JH, Readdy L, Wright D. Changes in resuscitation practice at birth. Arch Dis Child Fetal Neonatal Ed 2003;88:375-9.  Back to cited text no. 51      
52.Hoskyns EW, Milner AD, Hopkin IE. A simple method of face mask resuscitation at birth. Arch Dis Child 1987;62:376-8.  Back to cited text no. 52  [PUBMED]  [FULLTEXT]  
53.Cole AF, Rolbin SH, Hew EM, Pynn S. An improved ventilator system for delivery-room management of the newborn. Anesthesiology 1979;51:356-8.  Back to cited text no. 53  [PUBMED]  [FULLTEXT]  
54.Ganga-Zandzou PS, Diependaele JF, Storme L, Riou Y, Klosowski S, Rakza T, et al. Is Ambu ventilation of newborn infants a simple question of finger-touch? Arch Pediatr 1996;3:1270-2.  Back to cited text no. 54  [PUBMED]  [FULLTEXT]  
55.Finer NN, Rich W, Craft A, Henderson C. Comparison of methods of bag and mask ventilation for neonatal resuscitation. Resuscitation 2001;49:299-305.  Back to cited text no. 55  [PUBMED]  [FULLTEXT]  
56.Kanter RK. Evaluation of mask-bag ventilation in resuscitation of infants. Am J Dis Child 1987;141:761-3.  Back to cited text no. 56  [PUBMED]    
57.Esmail N, Saleh M, Ali A. Laryngeal mask airway versus endotracheal intubation for Apgar score improvement in neonatal resuscitation. Egyptian J Anesthesiol 2002;18:115-21.  Back to cited text no. 57      
58.Gandini D, Brimacombe JR. Neonatal resuscitation with the laryngeal mask airway in normal and low birth weight infants. Anesth Analg 1999;89:642-3.  Back to cited text no. 58  [PUBMED]  [FULLTEXT]  
59.Brimacombe J, Gandini D. Airway rescue and drug delivery in an 800 g neonate with the laryngeal mask airway. Paediatr Anaesth 1999;9:178.  Back to cited text no. 59  [PUBMED]  [FULLTEXT]  
60.Lonnqvist PA. Successful use of laryngeal mask airway in low-weight expremature infants with bronchopulmonary dysplasia undergoing cryotherapy for retinopathy of the premature. Anesthesiology 1995;83:422-4.  Back to cited text no. 60      
61.Paterson SJ, Byrne PJ, Molesky MG, Seal RF, Finucane BT. Neonatal resuscitation using the laryngeal mask airway. Anesthesiology. 1994;80:1248 -1253  Back to cited text no. 61      
62.Singh R, Mohan CV, Taxak S. Controlled trial to evaluate the use of LMA for neonatal resuscitation. J Anaesthesiol Clin Pharmacol 2005;21:303-6.  Back to cited text no. 62      
63.Trevisanuto D, Ferrarese P, Zanardo V, Chiandetti L. Laryngeal mask airway in neonatal resuscitation: a survey of current practice and perceived role by anaesthesiologists and paediatricians. Resuscitation 2004;60:291-6.  Back to cited text no. 63  [PUBMED]  [FULLTEXT]  
64.Hansen TG, Joensen H, Henneberg SW, Hole P. Laryngeal mask airway guided tracheal intubation in a neonate with the Pierre Robin syndrome. Acta Anaesthesiol Scand 1995;39:129-31.  Back to cited text no. 64  [PUBMED]    
65.Osses H, Poblete M, Asenjo F. Laryngeal mask for difficult intubation in children. Paediatr Anaesth 1999;9:399-401.  Back to cited text no. 65  [PUBMED]  [FULLTEXT]  
66.Stocks RM, Egerman R, Thompson JW, Peery M. Airway management of the severely retrognathic child: use of the laryngeal mask airway. Ear Nose Throat J 2002;81:223-6.  Back to cited text no. 66  [PUBMED]    
67.Palme-Kilander C, Tunell R. Pulmonary gas exchange during facemask ventilation immediately after birth. Arch Dis Child 1993;68:11-6.  Back to cited text no. 67  [PUBMED]  [FULLTEXT]  
68.Aziz HF, Martin JB, Moore JJ. The pediatric disposable end-tidal carbon dioxide detector role in endotracheal intubation in newborns. J Perinatol 1999;19:110-3.  Back to cited text no. 68  [PUBMED]    
69.Bhende MS, Thompson AE. Evaluation of an end-tidal CO2 detector during pediatric cardiopulmonary resuscitation. Pediatrics 1995;95:395-9.  Back to cited text no. 69  [PUBMED]    
70.Roberts WA, Maniscalco WM, Cohen AR, Litman RS, Chhibber A. The use of capnography for recognition of esophageal intubation in the neonatal intensive care unit. Pediatr Pulmonol 1995;19:262-8.  Back to cited text no. 70  [PUBMED]    
71.Repetto JE, Donohue PCP, Baker SF, Kelly L, Nogee LM. Use of capnography in the delivery room for assessment of endotracheal tube placement. J Perinatol 2001;21:284-7.  Back to cited text no. 71      
72.Orlowski JP. Optimum position for external cardiac compression in infants and young children. Ann Emerg Med 1986;15:667-73.  Back to cited text no. 72  [PUBMED]  [FULLTEXT]  
73.Phillips GW, Zideman DA. Relation of infant heart to sternum: its significance in cardiopulmonary resuscitation. Lancet 1986;1:1024-5.  Back to cited text no. 73  [PUBMED]  [FULLTEXT]  
74.David R. Closed chest cardiac massage in the newborn infant. Pediatrics 1988;81:552-4.  Back to cited text no. 74  [PUBMED]    
75.Todres ID, Rogers MC. Methods of external cardiac massage in the newborn infant. J Pediatr 1975;86:781-2.  Back to cited text no. 75  [PUBMED]    
76.Menegazzi JJ, Auble TE, Nicklas KA, Hosack GM, Rack L, Goode JS. Two-thumb versus two-finger chest compression during CRP in a swine infant model of cardiac arrest. Ann Emerg Med 1993;22:240-3.  Back to cited text no. 76  [PUBMED]    
77.Wyckoff MH, Berg RA. Optimizing chest compressions during delivery-room resuscitation. Semin Fetal Neonatal Med 2008;13:410-5.  Back to cited text no. 77  [PUBMED]  [FULLTEXT]  
78.Perlman JM, Risser R. Cardiopulmonary resuscitation in the delivery room: associated clinical events. Arch Pediatr Adolesc Med 1995;149:20-5.  Back to cited text no. 78  [PUBMED]  [FULLTEXT]  
79.Ralston SH, Voorhees WD, Babbs CF. Intrapulmonary epinephrine during prolonged cardiopulmonary resuscitation: improved regional blood flow and resuscitation in dogs. Ann Emerg Med 1984;13:79-86.  Back to cited text no. 79  [PUBMED]  [FULLTEXT]  
80.Ralston SH, Tacker WA, Showen L, Carter A, Babbs CF. Endotracheal versus intravenous epinephrine during electromechanical dissociation with CPR in dogs. Ann Emerg Med 1985;14:1044-8.  Back to cited text no. 80  [PUBMED]  [FULLTEXT]  
81.Redding JS, Pearson JW. Metabolic acidosis: a factor in cardiac resuscitation. South Med J 1967;60:926-32.  Back to cited text no. 81  [PUBMED]  [FULLTEXT]  
82.Kleinman ME, Oh W, Stonestreet BS. Comparison of intravenous and endotracheal epinephrine during cardiopulmonary resuscitation in newborn piglets. Crit Care Med 1999;27:2748-54.  Back to cited text no. 82  [PUBMED]  [FULLTEXT]  
83.Barber CA, Wyckoff MH. Use and efficacy of endotracheal versus intravenous epinephrine during neonatal cardiopulmonary resuscitation in the delivery room. Pediatrics 2006;118:1028-34.  Back to cited text no. 83  [PUBMED]  [FULLTEXT]  
84.Berg RA, Otto CW, Kern KB, Hilwig RW, Sanders AB, Henry CP, et al. A randomized, blinded trial of high-dose epinephrine versus standard-dose epinephrine in a swine model of pediatric asphyxial cardiac arrest. Crit Care Med 1996;24:1695-700.  Back to cited text no. 84  [PUBMED]  [FULLTEXT]  
85.Burchfield DJ, Preziosi MP, Lucas VW, Fan J. Effects of graded doses of epinephrine during asphxia-induced bradycardia in newborn lambs. Resuscitation 1993;25:235-44.  Back to cited text no. 85  [PUBMED]    
86.Perondi MB, Reis AG, Paiva EF, Nadkarni VM, Berg RA. A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest. N Engl J Med 2004;350:1722-30.  Back to cited text no. 86  [PUBMED]  [FULLTEXT]  
87.So KW, Fok TF, Ng PC, Wong WW, Cheung KL. Randomised controlled trial of colloid or crystalloid in hypotensive preterm infants. Arch Dis Child Fetal Neonatal Ed 1997;76:F43-6.  Back to cited text no. 87  [PUBMED]  [FULLTEXT]  
88.Emery EF, Greenough A, Gamsu HR. Randomised controlled trial of colloid infusions in hypotensive preterm infants. Arch Dis Child 1992;67:1185-8.  Back to cited text no. 88  [PUBMED]  [FULLTEXT]  
89.Oca MJ, Nelson M, Donn SM. Randomized trial of normal saline versus 5% albumin for the treatment of neonatal hypotension. J Perinatol 2003;23:473-6.  Back to cited text no. 89  [PUBMED]  [FULLTEXT]  
90.Gibbs J, Newson T, Williams J, Davidson DC. Naloxone hazard in infant of opioid abuser. Lancet 1989;2:159-60.  Back to cited text no. 90  [PUBMED]  [FULLTEXT]  
91.Vannucci RC, Vannucci SJ. Cerebral carbohydrate metabolism during hypoglycaemia and anoxia in newborn rats. Ann Neurol 1978;4:73-9.  Back to cited text no. 91  [PUBMED]    
92.Salhab WA, Wyckoff MH, Laptook AR, Perlman JM. Initial hypoglycaemia and neonatal brain injury in term infants with severe fetal acidemia. Pediatrics 2004;114:361-6.  Back to cited text no. 92  [PUBMED]  [FULLTEXT]  
93.Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;365:663-70.  Back to cited text no. 93  [PUBMED]  [FULLTEXT]  
94.Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischaemic encephalopathy. N Engl J Med 2005;353:1574-84.  Back to cited text no. 94  [PUBMED]  [FULLTEXT]  
95.Eicher DJ, Wagner CL, Katikaneni LP, Hulsey TC, Bass WT, Kaufman DA, et al. Moderate hypothermia in neonatal encephalopathy: safety outcomes. Pediatr Neurol 2005;32:18-24.  Back to cited text no. 95  [PUBMED]  [FULLTEXT]  
96.Eicher DJ, Wagner CL, Katikaneni LP, Hulsey TC, Bass WT, Kaufman DA, et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol 2005;32:11-7.  Back to cited text no. 96  [PUBMED]  [FULLTEXT]  
97.Thoresen M, Whitelaw A. Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischaemic encephalopathy. Pediatrics 2000;106:92-9.  Back to cited text no. 97  [PUBMED]  [FULLTEXT]  
98.Shankaran S, Laptook A, Wright LL, Ehrenkranz RA, Donovan EF, Fanaroff AA, et al. Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants. Pediatrics 2002;110:377-85.  Back to cited text no. 98  [PUBMED]  [FULLTEXT]  


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1]


This article has been cited by
1 Palliative care in the neonatal intensive care unit: An Indian experience
Arunangshu Ghoshal,Anuja Damani,MaryAnn Muckaden
Journal of Neonatal Nursing. 2016;
[Pubmed] | [DOI]
2 What is the evidence for the use of adrenaline in the treatment of neonatal hypotension?
Mahoney, L. and Crook, D. and Walter, K.N. and Sherman, E. and Rabe, H.
Cardiovascular and Hematological Agents in Medicinal Chemistry. 2012; 10(1): 50-98
[Pubmed]
3 Is there a role of palliative care in the neonatal intensive care unit in India?
Dighe, M.P., Muckaden, M.A., Manerkar, S.A., Duraisamy, B.P.
Indian Journal of Palliative Care. 2011; 17(2): 104-107
[Pubmed]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
    Introduction
    Initial Steps
    Special Situations
    Post-Resuscitati...
    Guidelines for W...
    Current Issues
    Conclusion
    References
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed11711    
    Printed170    
    Emailed2    
    PDF Downloaded1934    
    Comments [Add]    
    Cited by others 3    

Recommend this journal