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CASE REPORT
Year : 2011  |  Volume : 55  |  Issue : 3  |  Page : 290-292

Fulminant hepatic failure after repeated exposure to isoflurane


1 Department of Anaesthesiology & Critical Care, BGS Global Hospitals, Bangalore, Karnataka, India
2 Department of Neurosurgery, BGS Global Hospitals, Bangalore, Karnataka, India
3 Department of Pathology, BGS Global Hospitals, Bangalore, Karnataka, India

Correspondence Address:
Keshavan H Venkatesh
Department of Anaesthesiology & Critical Care, BGS Global Hospitals, Bangalore 560080, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5049.82696

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Inhalational agents are used routinely for maintenance of anaesthesia. Post anaesthesia hepatic failure has been documented following exposure to halothane. However, there are very few reports of such complications following isoflurane anaesthesia. A 6-year-old child developed fulminant hepatic failure 2 days following craniotomy under general anaesthesia. There was no evidence of viral, autoimmune, or metabolic causes of hepatitis. No other medications known to cause hepatitis, except low dose paracetamol, were administered. The clinical and histological picture of our case is similar to that of halothane hepatitis, which has a significant mortality rate. We report this as a possible fulminant hepatic failure resulting from exposure to isoflurane anaesthesia.


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