| CLINICAL INVESTIGATION |
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| Year : 2012 | Volume
: 56
| Issue : 2 | Page : 139-144 |
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Intubating conditions following rapid sequence induction with three doses of succinylcholine
Smita Prakash1, Sushma Barde2, Preeti Thakur3, Anoop Raj Gogia1, Rajvir Singh4
1 Consultant, Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India
2 Associate Consultant Anaesthesia, Medanta - The Medicity, Sector 38, Gurgaon, Haryana, India
3 Assistant Professor, Army College of Medical Sciences and Base Hospital, Delhi Cantt., India
4 Consultant, Medical Research Cardiology, HMC, Doha, Qatar
Correspondence Address:
Smita Prakash
C 17 HUDCO Place, New Delhi - 110 049
India
DOI: 10.4103/0019-5049.96309
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Background: The aim of this prospective, randomized, double-blind study was to compare tracheal intubating conditions and the duration of apnoea following administration of 0.4, 0.6 and 1.0 mg/kg of succinylcholine during simulated rapid sequence induction of anaesthesia. Methods: Anaesthesia was induced with fentanyl 2 μg/kg and propofol 2 mg/kg followed by application of cricoid pressure. Patients were randomly allocated to three groups according to the dose of succinylcholine administered (0.4, 0.6 or 1.0 mg/kg). Intubating conditions were assessed at 60 s after succinylcholine administration. Time to first diaphragmatic contraction (apnoea time) and time to resumption of regular spontaneous breathing were noted. Results: Excellent intubating conditions were obtained in 52.4%, 95.7% and 100% of the patients after 0.4, 0.6 and 1.0 mg/kg succinylcholine, respectively; P<0.001. Acceptable intubating conditions (excellent and good grade combined) were obtained in 66.7%, 100% and 100% of the patients after 0.4, 0.6 and 1.0 mg/ kg succinylcholine, respectively; P<0.001. Apnoea time and resumption of regular spontaneous breathing were dose-dependent. Apnoea time was 3.8±1.1 min, 4.3±0.9 min and 8.2±3.4 min in groups 0.4, 0.6 and 1.0 mg/kg, respectively; P<0.001. Time to regular spontaneous breathing was 5.3±1.2 min, 5.5±1.1 min and 8.9±3.5 min in groups 0.4, 0.6 and 1.0 mg/kg, respectively; P<0.001. Conclusion: A dose of 0.6 mg/kg succinylcholine can be used for rapid sequence induction of anaesthesia as it provides acceptable intubating conditions with a shorter apnoea time compared with a dose of 1 mg/kg. |
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