Indian Journal of Anaesthesia  
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Year : 2013  |  Volume : 57  |  Issue : 3  |  Page : 230-235

A simple method for evaluation of the uptake of isoflurane and its comparison with the square root of time model

1 Department of Anaesthesiology and Pain Medicine, Fellow Liver Transplant Anaesthesia, Asan Medical Centre, Seoul, Korea
2 Department of Anaesthesia and Critical Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Goverdhan Dutt Puri
Department of Anaesthesia and Critical Care, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5049.115587

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Background: The square root of time (SqRT) model had been used to predict the uptake of volatile agents. Methods: We studied the rate of uptake of isoflurane in 10 patients using liquid isoflurane infusion through syringe pump into the closed circuit. The infusion rates were titrated to maintain a constant end tidal concentration of isoflurane of 1.5%. The predicted uptake values were also calculated from the square root principle and compared with the derived uptake. Results: The observed rate of uptake was higher than predicted from the Lowe and Ernst equation (P<0.001). There exists considerable inter-individual variability in uptake pharmacokinetics and it showed statistically significant correlation with ideal body weight, body weight (P<0.01), body surface area, and body weight 3/4 from 30 min of start of isoflurane infusion (P<0.05). Conclusion: SqRT model is inaccurate in predicting isoflurane uptake and underestimates it during closed circuit anaesthesia.

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