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LETTER TO EDITOR
Year : 2013  |  Volume : 57  |  Issue : 4  |  Page : 430-431  

Response: Comparative electrocardiographic effects of intravenous ondansetron and granisetron in patients undergoing surgery for carcinoma breast: A prospective single blind randomised trial


Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Mumbai, Maharashtra, India

Date of Web Publication20-Sep-2013

Correspondence Address:
Atul P Kulkarmi
Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Dr. E Borges Road, Parel (E), Mumbai - 400 012, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5049.118528

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How to cite this article:
Ganjare A, Kulkarmi AP. Response: Comparative electrocardiographic effects of intravenous ondansetron and granisetron in patients undergoing surgery for carcinoma breast: A prospective single blind randomised trial. Indian J Anaesth 2013;57:430-1

How to cite this URL:
Ganjare A, Kulkarmi AP. Response: Comparative electrocardiographic effects of intravenous ondansetron and granisetron in patients undergoing surgery for carcinoma breast: A prospective single blind randomised trial. Indian J Anaesth [serial online] 2013 [cited 2020 Mar 29];57:430-1. Available from: http://www.ijaweb.org/text.asp?2013/57/4/430/118528

Sir,

We thank the correspondents for their interest and comments on our article. [1],[2] We agree that the routine practice is to give antiemetics during surgery. However as discussed by us in the article, this would have confounded the effects of the antiemetic drugs on QTc interval. We do not have data on the incidence of nausea and vomiting as the aim of our study was to check the safety profile and not the efficacy. The antiemetics were given for prophylaxis and not treatment. We used 8mg of ondansetron and 1mg of granisetron as this was the standard of care in our institute that time and we wanted the study to reflect normal clinical practice.

This study was conducted in 2006-2007 while the Food and Drugs Administration advisory was issued in 2011 as quoted by the correspondents. In2006,this was the standard of care in our institute while granisetron was just launched that year in India.

We hope this satisfies the queries raised and we once again thank them for their interest.

 
   References Top

1.Ganjare A, Kulkarni AP. Comparative electrocardiographic effects of intravenous ondansetron and granisetron in patients undergoing surgery for carcinoma breast: A prospective single-blind randomised trial. Indian J Anaesth 2013;57:41-5.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Hanumanthaiah D, Sudhir V. Comment: Ondansetron: Timing and dosage. Indian J Anaesth 2013;57:429-30.  Back to cited text no. 2
  Medknow Journal  




 

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