|Year : 2015 | Volume
| Issue : 9 | Page : 606-617
Lung isolation, one-lung ventilation and hypoxaemia during lung isolation
Atul Purohit1, Suresh Bhargava2, Vandana Mangal3, Vinod Kumar Parashar1
1 Department of Anaesthesiology, SIDSS, Santokba Durlabhji Memorial Hospital, Jaipur, Rajasthan, India
2 Department of Anesthesia and Critical Care, Mahatma Gandhi Medical College, Jaipur, Rajasthan, India
3 Department of Anesthesia, SMS Medical College, Jaipur, Rajasthan, India
|Date of Web Publication||21-Sep-2015|
C-26, Mukherji Colony, Shastri Nagar, Jaipur - 302 016, Rajasthan
Source of Support: Nil., Conflict of Interest: There are no conflicts of interest.
Lung isolation is being used more frequently in both adult and paediatric age groups due to increasing incidence of thoracoscopy and video-assisted thoracoscopic surgery in these patients. Various indications for lung isolation and one-lung ventilation include surgical and non-surgical reasons. Isolation can be achieved by double-lumen endotracheal tubes or bronchial blocker. Different issues arise in prone and semi-prone position. The management of hypoxia with lung isolation is a stepwise drill of adding inhaled oxygen, adding positive end-expiratory pressure to ventilated lung and continuous positive airway pressure to non-ventilated side.
Keywords: Hypoxia, lung isolation, one-lung ventilation, shunt fraction, techniques
|How to cite this article:|
Purohit A, Bhargava S, Mangal V, Parashar VK. Lung isolation, one-lung ventilation and hypoxaemia during lung isolation. Indian J Anaesth 2015;59:606-17
|How to cite this URL:|
Purohit A, Bhargava S, Mangal V, Parashar VK. Lung isolation, one-lung ventilation and hypoxaemia during lung isolation. Indian J Anaesth [serial online] 2015 [cited 2020 Aug 10];59:606-17. Available from: http://www.ijaweb.org/text.asp?2015/59/9/606/165855
| Introduction|| |
The two lungs on each side of the thoracic cavity are two separate organs morphologically, but act as one functional unit, inflating and deflating in unison to maintain the normal levels of oxygen and CO2 in the blood. However, situations arise when separation of these two from each other becomes desirable for retrieving, retaining or maintaining healthy, normal functioning of the body. This separation of two lungs, termed as 'lung isolation', makes each of them function as an independent unit and is achieved by preparation of the airway through proper manipulation and instrumentation. This provides improved exposure of the surgical field, and protection of healthy lung from infected or bleeding one. However, on the flip side of it, one-lung ventilation (OLV) also causes more manipulation of airway, and hence more damage, and leads to significant physiological derangements such as ventilation-perfusion mismatching and early development of hypoxia.
The present review aims at making the learning and practicing anaesthesiologist familiar with the method of isolating lungs in both adults and paediatric age groups, the physiological changes that occur during OLV and the methods to prevent and treat hypoxia if it occurs during OLV.
For the purpose of writing a proper review, reference were included from textbooks, journals and online research sources including Medline and PubMed, and all relevant references were included till the latest, 2014.
| Indications of One-Lung Ventilation|| |
Related to respiratory system
Lung resection procedures
Video-assisted thoracoscopic surgery (VATS)
Diaphragmatic hernia repair (thoracic approach)
Single-lung transplant post-operative complications.
Related to cardiovascular system
Minimally invasive cardiac surgeries
Aortic arch surgeries
Dissecting aneurysm of aortic arch
Repair of pericardial window
Related to esophagus
Minimally invasive thoraco-laparoscopic oesophagectomy.
Anterior fixation of the thoracic spine.
Split/differential lung ventilation
Unilateral lung haemorrhages
Ventilation in bronchopleural fistulae
Prevention of spillage from infective to the non-infective lung.
| Techniques of Lung Separation|| |
In general, two methods have been used for isolating a lung.
These are of two types:
- Single-lumen endobronchial tubes (EBTs), which are longer than normal endotracheal tubes, but with smaller external diameters and smaller cuffs. These tubes are inserted into a particular main-stem bronchus; ventilate that side lung, causing spontaneous absorption collapse of the other lung. This is a not so commonly used method for lung isolation, and if used, is employed only in small children. An important feature of EBTs is a narrow bronchial cuff and a relatively short distance from the proximal age of that cuff to the distal tip of the tube. Thus, there is a lesser chance of bronchial cuff obstructing the upper lobe bronchus that may occur easily if single-lumen endotracheal tubes (ETTs) are used for this purpose. This 'margin of safety', is defined as the length of the tracheobronchial tree over which a tube can be moved or positioned without obstructing a conducting airway. This is very small with normal ETTs and much larger for EBTs. For emergency situations, normal ETTs can be used, e.g., acute contralateral tension pneumothorax, acute airway haemorrhages etc., but for all situations double-lumen tubes (DLTs)/bronchial blockers (BBs) are a better choice.
- DLTs: By far, the most commonly used method of lung isolation used since they have been introduced, DLTs have been modified in the various base from 1931 till date. DLT's, first used in 1931 by gale and waters  as a cuffed rubber ETT pushed into bronchus of the desired side, have come a long way passing through stages of Carlens catheter  (DLT with hook at carina to ensure correct tube positioning-only left-side), Bryce-Smith tube  (left-side DLT without carinal hook) Robertshaw tubes  (present day red-rubber rigid, fixed curvature DLT), to disposable plastic Broncho-Cath ® and next to the Silbroncho tubes  (left-side soft EBT made of silicon rubber with bronchial part wire-reinforced). These have many advantages [Table 1] to offer over the other methods used for lung isolation, such as the ease of insertion and confirmation of position and the ability to isolate, selectively ventilate or collapse either lung independently according to operative requirement.
These are inflatable balloon-tipped stylets inserted in the desired bronchus to cause blockade of aeration of that particular segment of lung causing collapse, distal to the blocker.,,
| Double-Lumen Tubes|| |
All DLTs are essentially two tubes of unequal length, joined together side by side to form one single unit. The two are separated at their proximal end to facilitate independent connection to separate breathing circuits, or to the same circuit through a Y-connector. At the distal end, the shorter tube ends to lie in mid-trachea and the longer tube more distally into the main-stem bronchus of the desired side, to which the DLT is ascribed. All DLTs are curved in two planes. The main-stem which lies in the trachea is concave anteriorly while the more distal bronchial portion is curved at right angle to this with concavity towards the side whose bronchus is to be negotiated (viz., concavity of right-sided DLT bronchial part is towards the right-side). DLTs are side-specific meaning that they are either left-sided or right-sided and the two differ in their structure slightly. Due to the lesser angulation of the right bronchus with the trachea, the right DLT is lesser oblique at its bronchial part than the left. Also, the right DLT has a special opening for right upper lobe (RUL) bronchus, in its bronchial stem, before it ends finally between the points of RUL bronchus' origin and right bronchial carina, a distance of about 2 cm. For this reason, the cuff of right DLT is either obliquely shaped, with RUL bronchial opening incorporated in the slanting cuff in Broncho-Cath ® (Mallinckrodt Inc., St. Louis, Missouri, USA) of DLTs, or has two smaller cuffs, the RUL bronchial opening lying between them in Rusch ® tubes.
The most commonly used DLT at present are the disposable plastic-cuffed DLTs. These are available in sizes 30, 32, 33, 35, 37, 39 and 41 Fr (both sides) for adults and 26 and 28 (left-side only) for children of 8 to 12 years age. The tracheal and bronchial components of these tubes are color-coded as white and blue, respectively, and have respective cuffs with the same colour. Tracheal cuff, when inflated, allows positive pressure ventilation of both lungs and separation of lungs from the environment, while the inflation of bronchial cuff allows separation of the two lungs from each other. These tubes have a D-shaped lumen in the cross section.
Advantages and disadvantages of double-lumen tubes
These are presented in [Table 1].
Method of insertion of double-lumen tubes
As a standard precaution, the DLTs should be checked for their patency, integrity of cuff, the proper connections including the soft rubber extensions, the Y-connector to the circuit and finally the availability of the clamp used for blocking one side of the tube while checking the correct position. Under direct laryngoscopic vision, the DLT with its stylet in the bronchial lumen is introduced in the oral cavity, with a bronchial concavity facing anteriorly and advanced into the larynx. Once the bronchial cuff is beyond the glottis, at which point the more proximal tracheal cuff would be at the level of incisors, the stylet is removed and the tube rotated by 90° on its long axis towards the side to which it is to be inserted. Further negotiation of the tube can be with either of the following steps. One is to keep pushing the tube blindly till a definite resistance is encountered and pushing beyond which becomes evidently difficult. The tube has most likely reached the desired depth and can be checked by methods described later. The other method, described by Ovassapian, is inserting a flexible fibre-optic bronchoscope (FOB) into the bronchial lumen, seeing the carina, identifying the 'to be negotiated' bronchus entering this with the FOB and using this FOB as an optical stylet over which the bronchial part of the DLT is threaded.
Confirmation of position of double-lumen tube
This can be achieved by:
- Sequentially inflating the respective cuffs, blocking the individual components of the DLT (tracheal or bronchial) with a clamp and observing the entry and exit of air through the unblocked component, shown by appearance of water vapour during expiratory phase, observing the unilateral expansion of the chest and finally auscultating the chest for presence or absence of breath sounds or,
- Using the FOB to see inside both tracheal and bronchial lumina of DLT; when in tracheal lumen, the scope, immediately after coming out of the distal tracheal opening, should show the carina, the blue coloured bronchial stem of DLT entering into the respective bronchus, the inflated blue cuff occupying the entire bronchial lumen and absence of air leak and herniation of bronchial cuff into the other side bronchus across the carina [Figure 1]a. Under fibre-optic vision on right-side with right DLT's bronchial component in the right main bronchus, three openings viz., one proximal for RUL and two distal ones for right bronchial carina should be seen [Figure 1]b and [Figure 1]c. On the left-side, only two distal openings of left main bronchial carina would be seen [Figure 1]d, as there is no separate opening for left upper lobe bronchus proximally. The second method, that is, use of FOB to directly visualize the position of the DLT has been shown to increase the success rate of DLT insertion, to save time and reduce the complication rate and is strongly recommended.,
A recent development in facilitating, confirming the position of DLT and to identify its displacement is the VivaSight-DL ® (E.T. view Medical Ltd.,). This is a left-sided DLT (sizes 37, 39, 41 F only) with a high resolution camera at the tip of the tracheal lumen that remains connected to a monitor and allows continuous visualisation of tracheal carina. Any displacement from the desired position is easily detected and rapid repositioning achieved without disrupting the ventilation. This reduces the need of FOB, offers continuous visualisation of the position of the DLT around the carina  and is also expected to save time in inserting, confirming and repositioning of displaced DLT, once the learning curve is crossed.
|Figure 1:(a-d) Fibre-optic view of tracheal and bronchial carina with left sided double lumen tube in situ|
Click here to view
Choice of appropriate double-lumen tube
Three criteria need to be looked into. These are:
Complications of double-lumen tubes
- Side selection of DLT: As it is more technical and complicated to insert a right-side DLT due to exact adjustment of RUL branch opening of the bronchus and corresponding orifice in right-side DLT, it is usual to use left-sided DLTs as far as possible for OLV. The main argument against the use of right-side DLT is the relative low margin of safety due to this RUL bronchus anatomy. It entails more frequent displacement and hence more frequent repositioning for right DLTs. The left-sided tube can serve good for lung isolation, of all situations and there are very limited indications or using right-sided DLT. The right-sided DLTs are required in situ ations where left main bronchus has been anatomically altered significantly, e.g., due to compression by tumour or thoracic aortic aneurysm, or where surgical procedure involves the left main bronchus, e.g., left main bronchial resection or repair, left pneumonectomy or lung transplantation
- Size of DLT: The optimal size of DLT for an individual would be the largest tube that passes atraumatically through the glottic opening, advanced down the trachea and fits in the bronchus with a small air leak around the deflated cuff. A DLT too small requires a large cuff volume which could cause endobronchial cuff to herniate and block the other side bronchus, would have a narrower lumen and hence a higher airflow resistance and also pose difficulty in clearing secretions by suctioning. Many methods have been used studied to measure the thickness of bronchus to help estimate the size of DLT to be used. Usually, age, sex and height of the individual have been used to estimate the size of DLT. However, more objective evidence for this was provided by Brodsky et al., who used tracheal diameter measured on chest X-rays to estimate the bronchial size. They based their estimation on the bronchus-tracheal cross-sectional diameter ratio of 0.68 and concluded that irrespective of age or height, size 41 Fr DLT was appropriate for all male patients. However, no such specification was stated for females. Hannallah et al. measured left bronchial diameter on computed tomography scan. Brodsky et al. also found that tracheal width (TW) was the best predictor of left bronchial width (LBW) and the mathematical equation with normalisation of X-ray magnification, was suggested as: LBW (mm) =0.45 × TW (mm) +3.3 mm
- The depth of insertion of DLT: The tube should be inserted, as stated earlier, to the point where its further insertion faces an evident resistance. This in individuals of either sex, of 170 cm height is attained at 29 cm mark on the DLT. It was estimated by Brodsky, Benumof et al. that for each 10 cm increase or decrease in height, average placement depth was correspondingly increased or decreased by 1 cm. Chow et al. found that the depth of DLT insertion correlated significantly with the height and Clavicle-to-Carinal (Cl to Car) distance of trachea, with best correlation as: Depth of insertion (cm) = 0.75 × Cl to Car (cm)10 +0.112 × ht (cm) +6.
- Malposition – More than 1 cm change in either direction from the desired position of the DLT, as detected by flexible FOB, definitely needs correction.,, It is mandatory now as a standard of care to check with FOB, first after insertion and then after any change of position of the patient, especially from initial supine to final lateral surgical position. Wrongly positioned right-sided DLT will lead to collapse of RUL, if the two openings do not match with each other
- Airway trauma – Rupture of tracheobronchial tree, or direct trauma to vocal cords causing post-operative hoarseness of voice
- Others – Stapling of the bronchial lumen of DLT with the bronchus during pneumonectomy.
The DLT needs to be replaced with a single-lumen ETT post-operatively before the patient is shifted to the ICU, if post-operative ventilation is contemplated. This decision involves weighing of risk-benefit ratio by the anaesthesiologist, as changing the tube with a loss of airway control, and regaining it with ETT can be very risky at times; particularly when surgery has lasted long and fluid resuscitation with large amounts could have caused oedema of upper airway. For such occasions, airway exchange catheters (AECs) should be considered, the longer ones especially design for DLTs should be optimal. The AECs serve a dual purpose, it would act as a guide to the airway and would permit jet ventilation through the central lumen thus preventing hypoxia during airway exchange.
| Bronchial Blockers|| |
Besides the DLTs, another method for facilitating lung isolation involves blockade of a bronchus to allow lung collapse distal to the occlusion using devices known as the endobronchial blockers (EBBs). [Figure 3]a,[Figure 3]b,[Figure 3]c,[Figure 3]d,[Figure 3]e,[Figure 3]f These include Fogarty's, Foley's and Swan-Ganz catheters, Univent tubes and Torque Control Blocker Univent (TCBU) blockers, Coopdech blockers, Cohen's tip-deflecting blockers, Arndt wire-guided endobronchial blockade (WEB) blockers  and the latest EZ-blockers. [Table 3] enumerates the advantages and disadvantages of bronchial blockers in general. The salient features of each of these are discussed henceforth in adequate detail.
Fogarty's vascular embolectomy catheter
- Fogarty's vascular embolectomy catheter ® (Edwards Lifesciences, Irvine, CA, USA) These are balloon-tipped catheters [Figure 3]a, similar to the others including Foley's urethral and Swan-Ganz pulmonary arterial catheters with the distal end closed have very efficiently been used for blocking the main-stem or second generation bronchi in both adults and paediatric age groups. The advantages, disadvantages and other salient features are enumerated in [Table 3] and [Table 4].
The Univent tube
This device, introduced by Inoue in 1982,
is a flexible, single-lumen, 'silastic' ETT containing a
small additional channel within the concave anterior wall that houses a pre-shaped retractable cuffed bronchial blocker [Figure 2] and [Figure 3]b used for lung isolation. When retracted in the tube, this blocker acts as a stylet, angling the tip of the tube for an easier passage into the larynx. The salient features of this tube and the blocker (TCBU ®) (Vitaid Lewinston, NY, USA) are enumerated in [Table 4]. The smallest size tube (outer diameter 7.5/5 mm equivalent to 5.5 Fr ETT) can be used in children over 6–8 years of age only.
|Figure 2: Schematic diagram of the Univent tube with bronchial blocker in position|
Click here to view
Advantages of Univent tubes include
- Being shaped like a conventional single-lumen ET tube, these can be conveniently inserted under direct laryngoscopic vision, for cases of difficult intubation
- Can be used in fibre-optic intubation in an awake patient
- Can be used for selective lobar bronchial blockade
- Can be used as a regular ET tube without the need to change the tube, if post-operative ventilation is contemplated.
Disadvantages in addition to the ones stated in [Table 2] include higher bronchial cuff pressures causing injury to the intubated bronchus and costs higher than DLT's.
- This 9 Fr, 60 cm long blocker [Figure 3]c is featured with a spindle-shaped or a rectangular, blue coloured high volume low pressure cuff, a Murphy's eye, a central channel and a pre-formed angulated tip. It comes in two types, type 1 without auto inflation mechanism and type 2, with inflation mechanism which is controlled by a switch placed outside near the thumb of working hand of the operator. The blocker after being a place near the tracheal carina is guided further into the desired bronchus under direct FOB vision.
Wire-guided endobronchial blocker (WEB)
Wire-guided endobronchial blocker (Arndt blocker; Cook ® Critical Care, Bloomington, IN, USA) [Figure 3]d, after its introducer George Arndt (1994), it is considered an independent blocker and has two peculiar features. One, its tip is not pre-shaped or bent and second that the blocker has a narrow lumen in its centre (1.4 mm diameter) which lodges a plastic guide-wire turned into the shape of a loop at its distal end [Figure 4]a. The calibre of this loop can be changed from external manipulation at the proximal end. This wire loop is made to clinch the FOB and is inserted co-axially with the ET tube and beside the FOB, guiding the blocker to the desired bronchus; hence the name wire-enabled blocker or WEB. The cuff or balloon of the Arndt blocker comes in two shapes, one spherical preferred for the right-sided bronchial blockade, and the other more elongated and elliptically shaped preferably used for the left-sided bronchial blockade. The adapter for connecting the ETT to the ventilating circuit is also specially designed to allow for uninterrupted ventilation during insertion of the Arndt blocker. This unique Cook's multi-port adapter [Figure 4]b has four port openings. The distal one for connection to the ETT, one proximal one directed at right angle to the tube for connection to the breathing circuit, the one in line with ET tube for FOB and the fourth at an acute angle almost parallel to the FOB port for the Arndt blocker. The blocker can be inserted both co-axially and parallel to the ET tube [Table 3]. The Arndt blockers share all the advantages and disadvantages of bronchial blockers in general [Table 3], but have two additional disadvantages: (1) Once the web-guide or wire loop is removed, it cannot be re-inserted. Therefore, intra-operative repositioning of the blocker is difficult, for which a new blocker assembly has to be used and (2) more frequent malpositions when compared with TCBU.
Cohen tip-deflecting endobronchial blocker
Cohen tip-deflecting endobronchial blocker  [Figure 3]e, introduced in 2004 by Cook Critical Care is a 65 mm long catheter shaft with a distal nylon flexible tip which can be deflected approximately 30° in one plane. The FOB and BB can be passed sequentially in the ETT lumen, FOB following the blocker and the blocker placed in situ with lesser resistance. This device can be inserted in 7.5 mm i.d. single-lumen ET tube and hence, is used at best for large teenagers or adults. The manipulation of the tip can be done by a proximal control wheel that can be operated with thumb and index finger of the operator during insertion.
EZ-blocker [Figure 3]f is a Y-shaped bronchial blocker with the bifurcation of the main-stem into two distal extensions to be placed in both the main-stem bronchus. The salient features include central lumens of both stems extending into the main shaft and with ports to suck out secretions or to give continuous positive airway pressure (CPAP), radio-opaque shaft, special EZ-multi-port adapter, depth markers on the shaft and two extensions equipped with respective cuffs, each represented proximally by a colour-coded pilot-balloon. These can be inserted co-axially or para-axially, with the aid of FOB. Insertion and removal must be done with the cuffs completely deflated.
| Lung Isolation in Children|| |
The need for lung isolation in children is increasingly felt with increasing use of thoracoscopy and VATS in paediatric age group. The requirement of a silent lung provides an adequate working space in a relatively small anatomic compartment. In general, the equipment and techniques used for lung isolation in children have been touched upon in previous text; however the tubes or bronchial blockers to be selected for single lung ventilation in infants, children and teenagers have been presented in a tabulated form in [Table 4]. The single-lumen tubes, as described earlier are the simplest way of achieving lung isolation in children. This involves an intentional intubation of one particular bronchus with a thinner than normal conventional ETT until breath sounds on the operative side disappear. The FOB may be placed para-axially to confirm or guide the placement. The advantages include the simplicity of the method, no requirement of any special equipment except a FOB and the ability to be used as a life-saving procedure in emergency situations such as unilateral lung haemorrhages and contra-lateral tension pneumothorax. However, this method can cause failure to provide adequate seal of the intubated bronchus, especially if a smaller, uncuffed tube is used thus preventing the operated lung from adequately collapsing or failing to protect the ventilated healthy lung from contamination by purulent material in the contra-lateral lung. Inability to suction the operated lung and hypoxia occurring due to obstruction of the more proximally originating upper lobe bronchi, especially on the right-side, are the additional disadvantages of achieving lung isolation with this method. In this regard, the single-lumen endobronchial tubes with smaller bronchial cuffs have a larger 'margin of safety' than the uncuffed single-lumen ETTs. Additional methods described in literature for the same purpose include: (1) Extra-luminal or para-axial placement of EBBs preferred for small children due to non-availability of compatible equipment (ET tubes, FOBs, etc.,) for their co-axial placement. (2) Marraro paediatric endotracheal biluminal tube [Figure 5]. An assembly of two uncuffed tubes joined parallel to each other, with a shorter one as the tracheal part and longer on as the bronchial part. This tube has been reported to be safe and effective in children up to 3 years of age. (3) High-frequency oscillation (HFO) and high-frequency jet ventilation (HFJV) have been used to maintain oxygenation in OLV in children. This is applied to the non-dependent lung, just like CPAP and maintains the operated lung in a slightly distended position. (4) Other methods have also been described in sporadic case reports.,,
|Table 4: Tube/bronchial blocker selection for SLV in infants, children and teens|
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| Lung Isolation in Prone Position|| |
Use of DLT or OLV for VATS or thoracoscopy in prone or semi-prone position has been a matter of debate in various publications. This is due to the fact that while in the supine position for VATS where OLV is essential, it is not so in the prone position. Good surgical exposure can be achieved with single-lumen tube and double-lung ventilation for surgery in posterior mediastinum with the patient in prone. This is due to the tendency of the structures of anterior mediastinum falling away from the surgical field under the effect of gravity, making a space for the surgeon to work without the ipsilateral lung being collapsed. This has particularly been tried especially in thoraco-laparoscopic oesophagectomy and dorsal spine discoidectomy and fixation. Significant saving of time in preparing the patient for surgeon was achieved when normal single-lumen tube with double-lung ventilation was used, issues of tube displacement, checking and repositioning were avoided and post-operative respiratory functions were found to be better. However, the potential disadvantage of a single-lumen ETT is that if an emergency conversion to thoracotomy is required, OLV would be facilitated by a DLT in situ. Also, partial inflation of the operated lung due to ventilation in the presence of artificially induced capnothorax interferes with surgeon's vision. The practice at our centre for TLEs (thoraco laproscopic oesophagectomy) done in the prone position is to use a DLT and continue ventilating both lungs till a lung collapse is asked for by the surgeon or emergency clinical situation warrants it.
| Role of Ultrasonography in Lung Isolation|| |
Once DLT or BB has been positioned, the ultrasonography (USG) of the chest can be used as a convenient tool to confirm the adequacy of lung isolation. With the intercostal approach, an interface between the soft tissue of chest wall and aerated lung is seen as a hyperechoic line, 'the pleural line'. In ventilated lung, there is a to and fro movement at the pleural line that corresponds to tidal movement of the lung (lung sliding sign). In the non-ventilated lung, there is the absence of lung sliding, whereas in collapsed lung, the pleural line moves with a heartbeat in a pulsatile manner (lung-pulse sign). Lung-pulse is 93% sensitive and 100% specific for identification of lung collapse. Thus, if lung sliding on one side and lung-pulse on other are seen on USG, an adequate 'functional lung isolation' can be predicted.
| Pathophysiology of Hypoxaemia during One-Lung Ventilation|| |
Development of hypoxaemia (arterial oxygen saturation <90%) caused by OLV can be explained by following three factors.
Reduction in oxygen stores of the body, poor oxygenation and compromised ventilation
Directly due to the disease process and also the collapse of one-lung, the functional residual capacity and hence the oxygen stores of the body get significantly reduced in a situation of OLV. These as well as effects of anaesthesia and the lateral decubitus position make the patient highly prone to hypoxia. Compression of ventilated, dependent lung by the weight of mediastinum and by abdominal contents after diaphragmatic paralysis further adds to the gravity of atelectasis of the ventilated lung. Increased closure of small airways with old age, reduced elastic recoil and the lateral position lead further to more atelectasis and hence ventilation-perfusion mismatch, finally terminating in hypoxia.
Dissociation of oxygen from haemoglobin
Reduction in the cross-sectional area available for gaseous exchange to almost half due to non-ventilation of one out of two lungs causes a reduction in arterial oxygen partial pressures, increase in CO2 levels and respiratory acidosis. These physiological changes lead to rapid dissociation of oxygen from haemoglobin (Bohr effect), to enable easier and rapid release of oxygen to the peripheral tissues, as shown by the steep slope of the oxygen-dissociation curve.
During OLV, the non-ventilated lung gets perfused, though to a smaller extent than the dependent ventilated lung. This perfusion is a wasted perfusion and hence a shunt, and causes hypoxia. Lesser the shunt fraction, lesser would be the ventilation-perfusion mismatch and lesser the hypoxia. Three factors can contribute to reduction of this shunt fraction during OLV: (1) Surgical compression of blood vessels of operative, non-ventilated, non-dependent lung reduces the circulation of that lung and hence, portion of cardiac output going to it. (2) Gravitational effects shift more blood towards the dependent lung. (3) Hypoxic pulmonary vasoconstriction (HPV). This is a natural protective reflex that reduces pulmonary blood flow through non-ventilated lung by 40–50% during OLV resulting in moderation of hypoxia., This is a biphasic reaction with early response starting within seconds, reaching a peak at about 15 min followed by a delayed response in 4 h to cause maximal vasoconstriction.,, It is triggered at alveolar PO2 of <100 mmHg, the degree of which is proportional to the degree of hypoxia below this level. HPV response can be influenced by various peri-anaesthetic factors; chronic obstructive pulmonary disease (COPD), cirrhosis, sepsis, female sex, exercise, metabolic and respiratory alkalosis, hypocapnia, hypothermia, Trendelenburg position, haemodilution, nitrous oxide and inhalational anaesthetics especially Halothane cause inhibition of HPV response, that is, prevent correction of V/Q mismatch and hence causing more hypoxia during OLV. Systemic hypertension, metabolic acidosis, hypercapnia, hyperthermia, lateral decubitus position and surgical lung retraction, all potentiate HPV response and hence cause lesser hypoxia during OLV.
| Management of Hypoxia during One-Lung Ventilation|| |
The incidence of hypoxia during one-lung ventilation (SpO2 of <90%) is about 5%., This can be predicted, prevented and treated by adopting stepwise maneuvers.
Predicting hypoxemia during one-lung ventilation
A number of factors may predict the possibility of hypoxia during OLV. However, none of these could alone be able to predict the same, as hypoxia is due to play of multiple factors acting at the same time, and influencing each other and the lung physiology, per se.,,
Low PaO2 prior to OLV
Left-sided ventilation (due to the smaller size of left lung). A difference of 110 mmHg (280 vs. 170 mmHg) was found in PaO2 when right and left lungs were ventilated with 100% oxygen during OLV in a study by Schwarzkopf et al
Higher forced expiratory volume in 1 s (FEV1). This is seen in patients with obstructive lung disease and an inverse correlation exists between the FEV1 and the PaO2. This can be explained by the development of auto-positive end-expiratory pressure (PEEP) in pts with COPD due to air-trapping, thus reducing atelectasis and hence improving oxygenation. Also, air trapped in the non-ventilated lung tends to delay the onset of desaturation and hence hypoxia 
Distribution of perfusion: The shunt fraction is determined at least partly by the portion of cardiac output going to the non-ventilated, diseased lung. The lesser this lung gets, the more goes to the healthy, ventilated lung and the higher stays the PaO2. The availability of lung-perfusion scan can, therefore, indicate the probability of patient getting hypoxic during OLV. With the same reasoning, the large central parenchymal tumours that are relatively less perfused would pose the patient to hypoxia much lesser than the multiple smaller and peripheral metastatic lesions to be resected.
Prevention and treatment of hypoxemia during one-lung ventilation
Improve pre-operative lung function: The standard five pronged attack is used for pre-operative improvement. It includes reducing irritant exposure including smoking, bronchodilators for airway dilatation, mucolytic agent administration, chest physio-therapy to remove secretions and antibiotics to treat infection if present.
Traditionally, anaesthesiologists aim to attain a maximum possible SpO2 so that an adequate margin of safety is available in case of emergency. In OLV, such margin can be achieved only with increasing FiO2 to 100%. However, this FiO2 is liable to itself cause problems like hyperoxia, absorption collapse of alveoli, etc., It may be more prudent to tolerate SpO2 of 88% as the lowest value rather than aim for 100% SpO2 with high FiO2. Such a situation of prolonged desaturation, however, can be detrimental and needs a predetermined drill to manage the situation if it arises. The stepwise action plan is described henceforth in the following text:
- Assess position of DLT/BB-use FOB preferably 
- Clear airway of mucous secretions or blood in ventilated lung
- Increase PEEP up to 10 cm of water to ventilated lung. Higher PEEPs can cause diversion of blood from ventilated to non-ventilated side , increasing the shunt and worsening hypoxia. 10 cm of PEEP improves the FRC of dependent lung
- Increase FiO2, if lesser is being used, to 100% now
- CPAP or HFO or HFJV to non-ventilated side. This is acceptable only in open thoracotomies and not in VATS and thoracoscopic lung resections as this inflation of lung interferes with vision of surgeon and is usually discouraged
- Intermittent lung recruitment maneuvers  can be used on operated side of lung
- Suction catheter connected to auxiliary O2 port can be inserted in lumen of non-ventilated lung airway this prevents hypoxia without inflating the lung
- Optimisation of Hb levels and cardiac output
- If a pneumonectomy is planned, early clamping of pulmonary artery of non-ventilated lung eliminates the entire shunt, thus alleviating hypoxia
- At times, an intermittent double-lung ventilation technique may have to be resorted to, if nothing else works.
Modulation of perfusion by pharmacological interventions such as administration of nitric oxide and almitrine.,
Type of anaesthesia: TIVA versus inhalational anaesthesia-clinically insignificant differences on oxygenation with either of these.,,
| Controversies in Lung Isolation|| |
Lung isolation has been in use for long now, but in the absence of specific and clear guidelines, most of the issues discussed in the text still remain controversial. These include the choice of tube size, method of isolation chosen (SLETT/DLT/BB), unequivocal method of insertion and confirmation of correct placement (blind, clinical or under FOB vision), optimum FiO2 before and during OLV and the limits of acceptable degree of desaturation, just to name of few. There are choices available, each with its advantages and disadvantages, hence, the controversy continues!
| What to Use and When|| |
As discussed above, no one single method of lung isolation can be labelled to be the best. The use depends upon the situation and has to be decided on 'as and when' basis. However, Alsharani and Eldawlatly described an algorithm for this in 2014. This can at best be considered as a guide, but the decision lies with the clinician at the head end of the operation table.
| Summary|| |
Since the advent of OLV, the anaesthetic and surgical techniques have come a long way. The safety has increased and complications reduced manifold, as a result of improvement in technique and equipment. Also, lung isolation is now being used in more difficult, uncommon and versatile situations, hence presenting new paradigms for surgeons to explore new horizons with their skill. Development with the same pace is surely going to present the future anaesthesia colleagues with more challenges for their patients, and for themselves.
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Conflicts of interest
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[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]
[Table 1], [Table 2], [Table 3], [Table 4]