• Users Online: 3891
  • Print this page
  • Email this page
Year : 2017  |  Volume : 61  |  Issue : 11  |  Page : 923-929

Efficacy of transdermal buprenorphine patch on post-operative pain relief after elective spinal instrumentation surgery

1 Department of Anaesthesiology, Bangur Institute of Neurosciences, Kolkata, West Bengal, India
2 Department of Anaesthesiology, ESI Hospital, Kolkata, West Bengal; Department of Anaesthesiology, N.R.S. Medical College, Kolkata, West Bengal, India
3 Department of Anaesthesiology, Bangur Institute of Neurosciences, Kolkata, West Bengal; Department of Anaesthesiology, Sagar Dutta Medical College, Kolkata, West Bengal, India
4 Department of Anaesthesiology, I.P.G.M.E.R, Kolkata, West Bengal, India

Correspondence Address:
Saikat Niyogi
OMM Tower, Flat 3A (3rd Floor),4, No MM Feeder Road, Belghoria, Kolkata - 700 056, West Bengal
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ija.IJA_118_17

Rights and Permissions

Background and Aims: Transdermal buprenorphine patch (TDB) is increasingly used for chronic pain management because of non-invasive dosing, longer duration of action and minimal side effects. However its role in acute post-operative pain management for spinal instrumentation surgery is not well established. The aim of this study was to evaluate the analgesic efficacy of buprenorphine patch for postoperative pain relief in patients undergoing spinal instrumentation surgery. Methods: In this randomised, placebo-controlled, double-blinded, prospective study, 70 adult patients undergoing elective spinal instrumentation surgery were randomly allocated into two groups-TDB Group (buprenorphinepatch) and TDP Group (placebo patch). Time to first rescue analgesic requirement was the primary outcome. All patients also were monitored for total rescue analgesic requirement, drug-related adverse effect and haemodynamic status till 48 h after surgery. Statistical analysis was carried out using student independent t-test if normally distributed or with Mann–Whitney U-test if otherwise. Results: Time to first post-operative rescue analgesic (tramadol) requirement was much delayed in TDB Group than TDP Group (708.0 ± 6.98 min vs 54 ± 0.68 min, P < 0.001) and the total tramadol requirement was higher in TDB Group (490.60 ± 63.09 averagevs. 162.93 ± 63.91 mg, P < 0.001). Intra-and post-operative haemodynamic status was also stable in TDB Group without any adverse event. Conclusion: A TDB patch (10 μg/hour) applied 24 hours before surgery can be used as a postoperative analgesic for lumber fixation surgery without any drug-related adverse effect.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded571    
    Comments [Add]    

Recommend this journal