|Year : 2019 | Volume
| Issue : 5 | Page : 338-349
Integrating perioperative medicine with anaesthesia in India: Can the best be achieved? A review
SB Shah1, U Hariharan2, R Chawla1
1 Department of Anaesthesia and Critical Care, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India
2 Department of Anaesthesia and Intensive Care, Dr. Ram Manohar Lohia Hospital and PGIMER, CHS, New Delhi, India
|Date of Web Publication||13-May-2019|
Dr. S B Shah
H. No: 174 – 175, Ground Floor, Pocket-17, Sector-24, Rohini, Delhi - 110 085
Source of Support: None, Conflict of Interest: None
Integrating perioperative medicine with anaesthesia is the need of the hour. Evolution of a new superspeciality called perioperative anaesthesia can improve surgical outcomes by quality perioperative care and guarantee imminent escalation of influence and power for anaesthesiologists. All original peer-reviewed manuscripts pertaining to surgery-specific perioperative surgical home models involving preoperative, intraoperative and postoperative initiatives spanning the past 5 years have been reviewed using PubMed and Google Scholar. Whether the perioperative surgical home model is feasible or still a distant dream in the Indian perspective has been analysed.
Keywords: Enhanced recovery after surgery, perioperative medicine, surgical home
|How to cite this article:|
Shah S B, Hariharan U, Chawla R. Integrating perioperative medicine with anaesthesia in India: Can the best be achieved? A review. Indian J Anaesth 2019;63:338-49
|How to cite this URL:|
Shah S B, Hariharan U, Chawla R. Integrating perioperative medicine with anaesthesia in India: Can the best be achieved? A review. Indian J Anaesth [serial online] 2019 [cited 2020 Aug 7];63:338-49. Available from: http://www.ijaweb.org/text.asp?2019/63/5/338/258058
| Introduction|| |
Perioperative medicine signifies medical care of the patient right from admission, spanning the entire preoperative, intraoperative and postoperative periods. Worldwide, it is gaining acceptance that 'perioperative medicine' is the future of anaesthesiologists. RD Miller, whose writings are gospels in anaesthesia, while chairing the American Society of Anesthesiologists' 'task force on future (2025) paradigms of anaesthesia practice', stressed that we need to diversify our practice paradigms to ensure a future leadership position in medicine. The future is bright for anaesthesiologists who include perioperative medicine in their domain. Perioperative medicine can impart a new lease of life and relevance to our speciality which is largely retreating into the operation theatres (OTs): always behind the mask!
In this moment of truth, we can remain content with being a procedure-oriented speciality (intubation, neuraxial block, arterial cannulation) restricted to intraoperative care, or we could jump the OT confines and widen our clinical practice and intellectual domain to include quality perioperative medicine rooted in scientific research.Enhanced Recovery after Surgery (ERAS), Enhanced Perioperative Care (EPOC) programme and Perioperative Surgical Home (PSH) are some of the pragmatic quality improvement (QI) initiatives adopted in surgery. This article shall focus on the establishment and organisation of an EPOC programme.
| Methods|| |
A literature search was performed in January 2019 in MEDLINE, PubMed, EMBASE and the Cochrane Central Register of Controlled Trials for original peer-reviewed manuscripts pertaining to surgery-specific PSH models involving preoperative, intraoperative and postoperative initiatives spanning the past 5 years. A comprehensive search using PubMed and Google Scholar and reference crawling of all the selected articles retrieved 88 potentially relevant studies using keywords 'perioperative surgical home' and 'enhanced recovery after surgery'. We narrowed our review down to 35 studies after reviewing the abstract and methods' section of each article. There exists a paucity of Indian studies on surgery-specific PSH models.
| Lattice of Vertical and Horizontal Pathways|| |
Perioperative medicine is a network of vertical and horizontal pathways. Vertical pathways are based on surgical branches, for example, ERAS pathway for colorectal surgery and PSH model initiated for orthopaedic surgery. Here different sets of skills are required to run each constituent microsystem: nursing, nutritionists, physiotherapy, laboratory services, human resource, central sterilisation and supply department, information technology, social service and so on.
Horizontal pathways are based on symptoms or diseases cutting across patients from all surgical branches, for example, prehabilitation clinics (preoperative risk stratification, risk reduction and care optimisation clinic, obesity and weight loss clinic, perioperative optimisation for senior health clinic, pain clinic, postoperative nausea vomiting prophylaxis clinic, diabetes clinic, anaemia clinic, smoking-cessation clinic, nutrition-optimisation clinic), postoperative pain relief and so on.
| Perioperative Medicine: a Felt Need!|| |
Although a prerequisite for good postoperative results, skilful surgery is not the only deciding factor. Adverse events strike 30% of hospital admissions, nearly half of these being preventable. Emergency surgery has a much higher mortality attributed than elective surgery. A prospective cohort study on 187 patients, 82% with comorbidities, found a 14.4% in-hospital mortality. Multivariate logistic regression revealed that age increased the odds for mortality by 4%, while anaemia, chronic renal failure and sepsis increased the odds for mortality three, six and seven times, respectively. Emergency exploratory laparotomy was the procedure with the highest mortality (47.7%). Mortality rate after elective major abdominal surgeries stays between 3% and 7% in contrast. Complications were recorded in 52.4% of the patients. Infectious, pulmonary and cardiovascular events were the most frequent (36.4, 26.3 and 12.3%, respectively). Of 473,619 procedures considered in another study, 14.2% of patients underwent an emergency procedure. The odds ratio (OR) for such patients experiencing all-cause morbidity, serious morbidity and mortality was 1.20, 1.26 and 1.39, respectively. Another study found that Friday evening and weekend surgeries have higher morbidity and mortality compared with weekday surgeries. The adjusted odds for mortality were 44% and 82% higher for Friday and weekend procedures, respectively. Less senior and less experienced/trained staff was the explanation given. Tracking perioperative mortality for a basket of procedures revealed the mortality rates to be much higher for lower and middle-income countries.
Burden of comorbidities, emergent nature of surgery, weekend timing of surgery and the income bracket of the country influence the postoperative morbidity and mortality rate. The common string in these four factors is the lack of patient optimisation and inadequate perioperative care. The perioperative physician needs to fulfil this unmet need. In developed countries, it is the anaesthesiologist who is the perioperativist and his invovement leads to improvement in the surgical outcome. Developing nations, including India, are still undergoing this transition.
| Interlinking of the Preoperative, Intraoperative and Postoperative Periods|| |
Among the preoperative patient factors, although age of patient and nature/severity of disease are non-modifiable, preoperative screening and comorbidity optimisation are attainable by EPOC.
Intraoperative factors include risk of surgery, surgeon's skills, mode of anaesthesia, anaesthesiologist's skills, medical equipment quality and maintenance, surgical safety checklist, timeout before operation and sign-out after operation. EPOC can modify the last four factors.
Postoperative factors such as the discharge pathway (outpatient, day-care or inpatient surgery), postoperative surveillance for complications (availability and training of nursing staff, nurse–patient ratio, frequency of physician visits, point-of-care testing facility) and rescue ability after complications (parenteral antibiotics, blood bank, interventional radiology, intensive care beds, ventilators, dialysis unit, cath lab) are all EPOC-modifiable.
| Anaesthesiologist: the Natural Choice!|| |
By virtue of training, special skills and experience, anaesthesiologists are the most suitable perioperativists. Preoperative screening, evaluation, preparation, intraoperative anaesthetic and medical management, and acute postoperative care all fall in their purview. Many anaesthesiologists have additional training in critical care and are also pivotal members of multidisciplinary pain management teams. If anaesthesiologists can manage the potentially crisis-prone intraoperative period, they can be trusted upon to manage the pre- and postoperative periods too with equal efficiency. At the hands of a competent anaesthesiologist, this will also ensure continuity of care.
While surgical branches, like minarets of a monument, are quasi-independent units whose decisions and conduct are not controlled by others, anaesthesia is like the common platform holding these minarets. It traditionally caters to all surgical branches, each anaesthetist rotating between different surgical branches: neurosurgery, obstetrics, gastrointestinal surgery and so on.
Of late, superspecialisation in anaesthesia is trending, but it is debatable whether every neurosurgery case should be conducted by a neuroanaesthesiologist or whether all oncosurgery requires services of oncoanaesthesiologists. An oncoanaesthesiologist is a superspecialist with a difference. His superspeciality, just like cancer, is not restricted to one organ system. Further super superspecialisation into a head and neck oncoanaesthetist or a gynaeco-oncoanaesthetist would be absurd because he is the link between different surgical branches, who ensures smooth running of several parallel OTs through space, equipment, personnel and other resource management. Conversely, he needs to further diversify and incorporate perioperative medicine too. This dictum is applicable for all general anaesthesiologists too. Management of postoperative, chronic cancer and labour pains, cardiopulmonary resuscitation, blood transfusion and ventilator therapy all constitute the anaesthesiologist's domain.
| Establishment and Organisation of an Ideal Perioperative Care Programme|| |
Fragmented and variable perioperative care needs replacement with value-based, patient-centred care. Per-capita cost of healthcare is rising due to aging of population, personal income growth, spiralling prices in healthcare sector, administrative costs, defensive medicine, supplier-induced demand, technology-related changes in medical practice and changes in third-party payment including medical insurance policies. The ingredients/rudiments of a perioperative care programme pre-exist in most hospitals. They just need revamping, redesigning and reengineering to bridge strategy, operations, tactics and finance to create a pathway that embodies the'triple-aim' (Institute for Healthcare Improvement) of providing the individual patient a quality experience, best value for available resources (reduced cost) and improving overall population health. The anaesthesiologist should play a proactive leadership role to materialise this. The five steps to this effect are as follows:
A 'modified Delphi method' can be used to arrive at a consensus and create a protocol for diagnostic and treatment plans based on literature review, existing guidelines and discharge targets. Provision for point-of-care testing for early identification of modifiable high-risk patient conditions, standing perioperative medical instructions and pharmaceutical orders, preparation of flowsheets, nursing documentation, incorporation of external prescriptions, workflow analysis and workflow design, and staff and space management are important elements. A steering committee with representatives from all concerned specialities with an anaesthesiologist as the project leader should be formed. Electronic care coordination from the preoperative clinic through e-mails to the steering committee pertaining to baseline clinical condition of the patient, clinical updates, any abnormal laboratory investigation results or pending diagnostics, existing medication plan, history or predictors of difficult airway and special patient requests may prove fruitful.
Review committees and approval
Surgical recovery team review committee, nursing clinical practice review committee, pharmacy and therapeutics committee, prehabilitation and patient optimisation review committee and the medical archives committee (paper forms and electronic medical records) should meet face to face and give the new pathway their green signal.
The anaesthesiologists, internal medicine physicians, surgeons including surgery residents, nutritionists, physiotherapists and nursing staff should undergo rigorous training pertaining to specific requirements of the preoperative clinic and recovery room. Personnel should also be briefed on patient education, patient tracking and providing the patient with a care map so that the patient does not bear the burden of scheduling multiple appointments on his own which only adds to the stress of surgery. Wide distribution of educational material is required. Nurse practitioners should be trained enough to provide a 24 h/day, 7 days/week postoperative cover to maintain continuity of care under guidance of a perioperativist–anaesthesiologist.
Everyone starts the new EPOC pathway together on a predetermined date.
Audit and revision
Periodic data review is imperative for QI under a shoestring healthcare budget. Monthly individualised report cards must be issued to anaesthesiologists, surgeons and nursing staff.
The anaesthesiologist is at the hub centre of the spoked wheel of perioperative medicine [Figure 1]. The surgeon and internal medicine physician along with the nursing staff, nutritionists and physiotherapists assist him. Multidimensional communication oils this wheel, reducing inter-caregiver friction and discord between the caregivers and the patients. Reduced change in hands under the dynamic leadership of an anaesthesiologist shall lead to reduced loss of information and enhanced patient care.
|Figure 1: (Original): Organisation of enhanced perioperative care model with the anaesthetist at the hub centre|
Click here to view
In many models, such as the 'Fast track model', patients are under the surgeon's care after admission, under the anaesthesiologist's care intraoperatively and back under surgeon's care postoperatively. This is currently followed in India. The PSH model differs on three counts. First, the entire perioperative process, right from admission and one-stop surgery and anaesthesia preoperative visit for optimisation till PACU care and beyond for 30 days, involves active participation of the anaesthesiologists. Second, the anaesthesiologists exercise comprehensive perioperative medicine and third, anaesthesiologists assume a flagship position in clinical as well as material and human resource management. In India, anaesthesiology is a surgeon-dependent branch. Rapport with surgeons and fellow anaesthesiologists demarcates the degree of stress, duty hours and the type and quality of work output for any anaesthesiologist who is responsible mainly for the intraoperative care of the patient.
| Eras Pathway|| |
Elements of the ERAS pathways for different surgical subgroups are essentially the same with minor modifications.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, General elements include preoperative nutritional screening, no preoperative bowel preparation, maltodextrin drink 2 h before surgery, prophylactic antibiotics, epidural or patient-controlled analgesia, prokinetic agents, goal-directed fluid therapy, early mobilisation, predefined criteria for removal of drains, nasogastric tubes and catheters, immediate extubation, early oral intake and a specific discharge plan. Surgery-specific elements like octreotide for pancreaticoduodenectomies, minimal tissue handling and minimally invasive surgery for urogynaecological oncosurgery or pharmacological thromboprophylaxis for head and neck free-flap surgery are important. Several original studies have evaluated the ERAS protocol initially for colorectal,, followed by other surgeries. Advantages of adherence to ERAS are reduced length of hospital stay (LOS), reduced median operative time and intraoperative blood loss, reduced morbidity and complications, lower delayed gastric emptying rates, decreased insulin resistance, reduced IV fluid requirement during and for 3 days after surgery and improved 5-year survival [Table 1].,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, American Society for Enhanced Recovery and Perioperative Quality Initiative has recently (2018) issued joint consensus statements on optimal analgesia, prevention of postoperative infection, patient-reported outcome and postoperative gastrointestinal dysfunction within an ERAS pathway for colorectal surgery which were hitherto grey areas of the ERAS protocol, ushering an era of evidence-based perioperative medicine.,,,,,, Return to intended oncotherapy is another recent parameter and time to adjuvant chemotherapy post colorectal cancer surgery is associated with an improved survival rate. Besides elective colorectal surgery, ERAS Society guidelines (19 in number; available free from http://erassociety.org website) are now available for pancreaticoduodenectomy, rectal/pelvic surgery, hepatic resection, head and neck surgery with free-flap reconstruction, oesophageal, gastric and lung cancer surgery, radical prostatectomy, gynaecooncologic surgery, breast reconstruction and bariatic surgery. Indian Association for Parenteral and Enteral Nutrition is currently trying to develop India-specific ERAS guidelines (http://www.iapen.co.in).
|Table 1: Review of randomised controlled trials spanning past 5 years pertaining to ERAS and PSH models|
Click here to view
| PSH Model|| |
PSH is a patient-centred, team-based model, modifying healthcare economics, policy and organisation, adopted by the American Society of Anaesthesiologists, to enhance quality and patient safety, decrease costs, augment value and do away with fragmented and variable care. Many hospitals adopt the 'Lean Six Sigma' approach to embrace PSH. 'Lean' implies reduction of waste by rigorous standardisation methods. 'Six Sigma' signifies boosting customer/patient satisfaction by eradicating deficiencies and minimising divergence from the target goal. Low-risk patients need not be prescribed high-cost investigations and high-risk patients should undergo all investigations 1 day prior to surgery to avoid last-minute cancellations and rescheduling. Unnecessary preoperative investigations are multifactorial. They maybe an institutional protocol/practice tradition, be prescribed in the belief that other physicians require them or to surmount medicolegal aspects. Concerns about surgical delays and cancellations, and lack of guidelines are other factors which are addressed by the PSH model.
An ambulatory surgery PSH for laparoscopic cholecystectomy was introduced by Qiu et al. into a Kaiser Permanente model of care. They found a shorter LOS (162 vs 369 days) and reduced unplanned hospital admission (1.7% vs 8.5%) for patients admitted after PSH model implementation.
Under the same integrated delivery system, the same authors developed a PSH model for total knee arthroplasty and compared it with the older fast-track model. A reduced LOS of 2.4 ± 2.1 days for PSH versus 3.4 ± 2.9 days for fast-track was observed. The skilled nursing facility bypass rate was 94% in the PSH group compared with 80% in the reference group.
Garson et al. implemented a PSH model for elective total hip and knee arthroplasty (THA and TKA) with similar results. Vetter et al. in the same surgical subset found a $432 and $601 decrease in direct nonsurgery costs for the THA and TKA patients, respectively, increased on-time surgery starts and reduced anaesthesia-related delays and day-of-surgery case cancellations using a PSH model with the anaesthesiologist as the 'perioperativist'.
In a PSH model for posterior spinal fusion surgery for idiopathic scoliosis in adolescents, LOS decreased from 5.2 to 3.4 days in PSH patients who were significantly less likely to undergo perioperative blood transfusion (35% vs 11%; OR = 0.21) with significantly lower (2336 vs 1393 mL) crystalloid infusion.
Blueprints of two fresh PSH models based on a review of existing PSH models for other surgery types and tempered with the authors' experience in the field have been described specifically for robotic surgery and major head and neck oncosurgery [Table 2] and [Table 3].
|Table 2: Perioperative Surgical Home model for robotic radical hysterectomy and robot-assisted radical prostatectomy|
Click here to view
|Table 3: PSH model for major head and neck Sx requiring free-flap reconstruction|
Click here to view
| The Hospitalist Angle|| |
Till date, there exists only one society dedicated to hospital medicine (Society of Hospital Medicine), headquartered in Philadelphia, USA, with roughly 16,000 members who call themselves 'hospitalists'. It is very active and has already published practice guidelines for perioperative care, publishes an official journal (Journal of Hospital Medicine) and also offers Fellowships and a Masters degree in Hospital Medicine. Teamwork, QI and leadership are the three pillars on which the hospitalists have built their edifice. Members include physicians, practice administrators, nurse practitioners, physician assistants and pharmacists. Hospitalists are catering to a felt-need of the patients by filling a void left by office-based internal medicine physicians, surgeons and anaesthesiologists and are emerging as leaders of perioperative medicine care team. Progressive loss of influence of anaesthesiologists is foreseen if we do not embrace perioperative medicine amidst plenty of other takers, like the hospitalists.
Despite this threat, anaesthesiologists are still a divided lot!
Voices in favour of embracing hospital medicine
- Mission and vision: Keeping intraoperative medicine as the principal mission of anaesthesiology, the broader vision should be involvement in preoperative optimisation and postoperative care which is vital for the specialty's growth and evolution
- Widening vistas of knowledge: Perioperative medicine signifies a latitudinal increase in the anaesthesiologists' medical knowledge providing better insight into chronic comorbidities translating into better patient management and overall QI across the continuum of perioperative care
- Reduced last-minute case cancellations: A well-engineered, preoperative evaluation clinic with an anaesthesiologist as its dynamic director can reduce both the number of requests for referrals/consultations and the number of surgical cancellations attributable to inadequate preoperative preparation
- Monetary benefit: Significant cost savings can be achieved by reducing unnecessary testing and resource utilisation
- Improved interspecialty communication
- Differentiation of anaesthesiologists from nonphysician anaesthetists: This is by virtue of differences in the quality of perioperative care provided
- Seamless care transitions leading to enhanced patient care.
Voices of dissent
Anaesthesiologist as perioperativist is a recent development spelling change in the existing healthcare system. Resistance to change being a normal phenomenon, there are challenges ahead: challenges from within the anaesthesia community by the anaesthesiologists themselves to accept this new role and challenges from other specialities who might feel threatened by their dwindling role in perioperative care.
Perioperative medicine is not a coveted field for many anaesthesiologists. An 'anaesthetist' strictly means a person who delivers anaesthesia during the intraoperative period. When the surgeon pays us sufficiently for our sevices within the OT, why should we venture out of it? Why should we shoulder the additional responsibility of preoperative optimisation and postoperative care? The OT itself has such long working hours. Why should we reduce the quality of our life by assuming this extra burden? The temptation to avoid change is substantial, due to the comfortable lifestyle and financial reward of practice limited to the OT without hassles of admissions and discharges.
Perioperative medicine requires broader training across several specialities possibly translating into 'lengthened training periods' in this era of 'bridging courses' as short as 6 months. The perioperative period is ill-defined. With the power of perioperative medicine comes'responsibility,' which many anaesthesiologists are reluctant to shoulder.
| Practical Solutions|| |
All anaesthesiologists need not embrace perioperative medicine. A new superspeciality called 'perioperative anaesthesia' can be developed within anaesthesia just like neuroanaesthesia, cardiac anaesthesia and oncoanaesthesia. Anaesthesiologists with an inclination, aptitude and enthusiasm towards perioperative medicine can embrace this branch.
Till then, in perioperative clinics, a single anaesthesiologist should not be expected to give expert advice on all the aspects of prehabilitation. Rather, a group of anaesthesiologists each heading a specific field (diabetes clinic, smoking cessation clinic, pain clinic, nutrition optimisation clinic) can collectively share the responsibility of perioperative care.
| India-Specific Hurdles|| |
- Lack of awareness about the PSH concept
- Reluctance and partial acceptance since evidence-based recommendations may clash with their personal belief and traditional teaching
- Lopsided distribution of existing physicians especially the anaesthetists, most of them being concentrated in urban areas. India has only 1.27 anaesthesiologists for every 100,000 people, according to data from the World Federation of Societies of Anaesthesiologists. Most of them reside in cities
- Paucity of trained allopathic physicians and a poor doctor–patient ratio in India has led to contemplation of implementing 'bridging courses' from alternative medical therapy to allopathy
- Resource-constrained setting with paucity of material resources and monetary funds. Nonavailability of trained personnel, equipment and monitoring gadgets at district level and peripheral hospitals
- Pressure to cater to a burgeoning patient population with time and space limitations: Sheer quantity of cases makes quality take a backseat
- Urban sector corporate hospitals are better poised as far as infrastructure is concerned to adopt the EPOC pathway. Advent of medical tourism and catering to foreign patients is another factor in adopting EPOC in these hospitals.
Against this background of limited availability/acute shortage of trained anaesthesiologists, will the Indian healthcare system be able to integrate perioperative medicine with anaesthesia? Can the best be achieved as has been done in the developed nations? Although excellent for patients in terms of quality of care and costs, it is not possible to implement it without significant changes in the teaching and training curriculum involving a major role of professional bodies such as Medical Council of India and Indian Society of Anaesthesiologists. The medicolegal status of anaesthesiologists as perioperativists merits reconsideration.
Anaesthesia is the common platform on which the minarets of different branches of surgery stand which makes the anaesthetist best positioned to embrace perioperative medicine.
A new superspeciality for anaesthesiologists called 'perioperative medicine', akin to neuroanaesthesia or oncoanaesthesia, is the need of the hour.
EPOC pathways are the key to reducing postoperative morbidity and mortality.
EPOC pathways for emergency surgery may narrow the wide difference in mortality rates between elective and emergency surgery.
Against a backdrop of acute shortage of trained anaesthesiologists, it is debatable whether our Indian healthcare system is able to integrate perioperative medicine with anaesthesia and achieve the best as has been done in the West.
| Summary|| |
Intensivists have taken over critical care medicine. Before the powerful, lucrative and emerging field of perioperative medicine goes the critical care way we must wake up for the sake of our speciality. EPOC pathway for emergency surgery should be the next target after devising practical and cost-effective EPOC pathways for elective surgery with anaesthesiologist as the team leader. Urban sector corporate hospitals can lead the way in India.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Gan TJ, Scott M, Thacker J, Hedrick T, Thiele RH, Miller TE. American Society for Enhanced Recovery: Advancing enhanced recovery and perioperative medicine. Anesth Analg 2018;126:1870-3.
Grocott MP, Pearse RM. Perioperative medicine: The future of anaesthesia? Br J Anaesth 2012;108:723-6.
Cannesson M, Kain ZN. The role of perioperative goal-directed therapy in the era of enhanced recovery after surgery and perioperative surgical home. J Cardiothorac Vasc Anesth 2014;28:1633-4.
Cannesson M, Mahajan A. Vertical and horizontal pathways: Intersection and integration of enhanced recovery after surgery and the perioperative surgical home. Anesth Analg 2018;127:1275-7.
Cannesson M, Kain ZN. Enhanced recovery after surgery versus perioperative surgical home: Is it all in the name? Anesth Analg 2014;118:901-2.
Wang Y, Eldridge N, Metersky ML. National trends in patient safety for four common conditions. N
Engl J Med 2014;370:341-51.
Stahlschmidt A, Novelo B, AL, Passos SC, Dussán-Sarria JA, Félix EA. Predictors of in-hospital mortality in patients undergoing elective surgery in a university hospital: A prospective cohort. Brazilian J Anesth 2018;68:492-8.
Ingraham AM, Cohen ME, Raval MV, Ko CY, Nathens AB. Comparison of hospital performance in emergency versus elective general surgery operations at 198 hospitals. J American Col Surg 2011;212:20-8.
Aylin P, Alexandrescu R, Jen MH, Mayer EK, Bottle A. Day of week of procedure and 30 day mortality for elective surgery: Retrospective analysis of hospital episode statistics. Br Med J 2013;346:2424-9.
Vetter TR, Boudreaux AM, Jones KA, Hunter JM, Pittet JF. The perioperative surgical home: How anesthesiology can collaboratively achieve and leverage the triple aim in health care. Anesth Analg 2014;118:1131-6.
Chow VW, Hepner DL, Bader AM. Electronic care coordination from the preoperative clinic. Anesth Analg 2016;123:1458-62.
Vetter TR, Goeddel LA, Boudreaux AM, Hunt TR, Jones KA, Pittet JF. The perioperative surgical home: How can it make the case so everyone wins? BMC Anesthesiol 2013;13:6.
Zhao G, Cao S, Cui J. Fast-track surgery improves postoperative clinical recovery and reduces postoperative insulin resistance after esophagectomy for esophageal cancer. Support Care Cancer 2014;22:351-8.
Qiu C, Rinehart J, Nguyen VT, Cannesson M, Morkos A, LaPlace D, et al
. An ambulatory surgery Perioperative Surgical Home in Kaiser Permanente settings: Practice and outcomes. Anesth Analg 2017;124:768-74.
Gustafsson UO, Oppelstrup H, Thorell A, Nygren J, Ljungqvist O. Adherence to the ERAS protocol is associated with 5-year survival after colorectal cancer surgery: A retrospective cohort study. World J Surg 2016;40:1741-7.
Pal AR, Mitra S, Aich S, Goswami J. Existing practice of perioperative management of colorectal surgeries in a regional cancer institute and compliance with ERAS guidelines. Indian J Anaesth 2019;63:26-30.
] [Full text]
Group EC. The impact of enhanced recovery protocol compliance on elective colorectal cancer resection: Results from an international registry. Ann Surg 2015;261:1153-9.
Ford SJ, Adams D, Dudnikov S, Peyser P, Rahamim J, Wheatley TJ. The implementation and effectiveness of an enhanced recovery programme after oesophago-gastrectomy: A prospective cohort study. Int J Surg 2014;12:320-4.
Pan H, Hu X, Yu Z, Zhang R, Zhang W, Ge J. Use of a fast-track surgery protocol on patients undergoing minimally invasive oesophagectomy: Preliminary results. Interact Cardiovasc Thorac Surg 2014;19:441-7.
Al-Herz F, Sammour T, Milne H, Rhind B, Young M. Closing the audit cycle: Improving short-term outcomes of oesophagectomy in a provincial hospital. J Perioper Pract 2015;25:111-4.
Shewale JB, Correa AM, Baker CM, Villafane-Ferriol N, Hofstetter WL, Jordan VS. Impact of a fast-track esophagectomy protocol on esophageal cancer patient outcomes and hospital charges. Ann Surg 2015;261:1114-23.
Wang JY, Hong X, Chen GH, Li QC, Liu ZM. Clinical application of the fast track surgery model based on preoperative nutritional risk screening in patients with esophageal cancer. Asia Pac J Clin Nutr 2015;24:206-11.
Findlay JM, Tustian E, Millo J, Klucniks A, Sgromo B, Marshall RE. The effect of formalizing enhanced recovery after esophagectomy with a protocol. Dis Esophagus 2015;28:567-73.
Braga M, Pecorelli N, Ariotti R. Enhanced recovery after surgery pathway in patients undergoing pancreaticoduodenectomy. World J Surg 2014;38:2960-6.
Pillai SA, Palaniappan R, Pichaimuthu A, Rajendran KK, Sathyanesan J, Govindhan M. Feasibility of implementing fast-track surgery in pancreaticoduodenectomy with pancreaticogastrostomy for reconstruction – A prospective cohort study with historical control. Int J Surg 2014;12:1005-9.
Coolsen MM, van Dam RM, Chigharoe A, Olde Damink SW, Dejong CH. Improving outcome after pancreaticoduodenectomy: Experiences with implementing an enhanced recovery after surgery (ERAS) program. Dig Surg 2014;31:177-84.
Nussbaum DP, Penne K, Stinnett SS, Speicher PJ, Cocieru A, Blazer DG. A standardized care plan is associated with shorter hospital length of stay in patients undergoing pancreaticoduodenectomy. J Surg Res 2015;193:237-45.
Sutcliffe RP, Hamoui M, Isaac J. Implementation of an enhanced recovery pathway after pancreaticoduodenectomy in patients with low drain fluid amylase. World J Surg 2015;39:2023-30.
Morales Soriano R, Esteve Perez N, Tejada Gavela S. Enhanced recovery after surgery: Can we improve the results after pancreatoduodenectomy? Cir Esp 2015;93:509-15.
Williamsson C, Karlsson N, Sturesson C. Impact of a fast-track surgery programme for pancreaticoduodenectomy. Br J Surg 2015;102:1133-41.
Shao Z, Jin G, Ji. The role of fast-track surgery in pancreaticoduodenectomy: A retrospective cohort study of 635 consecutive resections. Int J Surg 2015;15:129-33.
Zouros E, Liakakos T, Machairas A, Patapis P, Agalianos C, Dervenis C. Improvement of gastric emptying by enhanced recovery after pancreaticoduodenectomy. Hepatobiliary Pancreat Dis Int 2016;15:198-208.
Bai X, Zhang X, Lu F, Li G, Gao S, Lou J, et al
. The implementation of an enhanced recovery after surgery (ERAS) program following pancreatic surgery in an academic medical center of China. Pancreatology 2016;16:665-70.
Dai J, Jiang Y, Fu D. Reducing postoperative complications and improving clinical outcome: Enhanced recovery after surgery in pancreaticoduodenectomy – A retrospective cohort study. Int J Surg 2017;39:176-81.
Gowda MS, Kumar AT, Sahoo MN. Early rehabilitation after surgery program versus conventional care during perioperative period in patients undergoing laparoscopic assisted total gastrectomy. J Min Access Surg 2014;10:132-8.
] [Full text]
Fujikuni N, Tanabe K, Tokumoto N, Suzuki T, Hattori M, Misumi T, et al.
Enhanced recovery program is safe and improves postoperative insulin resistance in gastrectomy. World J Gastrointest Surg 2016;8:382-8.
Abdikarim I, Cao XY, Li SZ, Zhao YQ, Taupyk Y, Wang Q. Enhanced recovery after surgery with laparoscopic radical gastrectomy for stomach carcinomas. World J Gastroenterol 2015;21:13339-44.
Liu G, Jian F, Wang X, Chen L. Fast-track surgery protocol in elderly patients undergoing laparoscopic radical gastrectomy for gastric cancer: A randomized controlled trial. Onco Targets Ther 2016;9:3345-51.
Fang F, Gao J, Bi X, Han F, Wang HJ. Effect and clinical significance of fast-track surgery combined with laparoscopic radical gastrectomy on the plasma level of vascular endothelial growth factor in gastric antrum cancer. Spring 2016;5:50-6.
Mingjie X, Luyao Z, Ze T, YinQuan Z, Quan W. Laparoscopic radical gastrectomy for resectable advanced gastric cancer within enhanced recovery programs: A prospective randomized controlled trial. J Laparoendosc Adv Surg Tech 2017;27:959-64.
Tanaka R, Lee SW, Kawai M, Tashiro K, Kawashima S, Kagota S, et al
. Protocol for enhanced recovery after surgery improves short-term outcomes for patients with gastric cancer: A randomized clinical trial. Gastric Cancer 2017;20:861-71.
Lai Y, Su J, Yang M, Zhou K, Che G. Impact and effect of preoperative short-term pulmonary rehabilitation training on lung cancer patients with mild to moderate chronic obstructive pulmonary disease: A randomized trial. Chin J Lung Cancer 2016;19:746-53.
Dong Q, Zhang K, Cao S, Cui J. Fast-track surgery versus conventional perioperative management of lung cancer-associated pneumonectomy: A randomized controlled clinical trial. World J Surg Oncol 2017;15:20-5.
Huang J, Lai Y, Zhou X. Short-term high-intensity rehabilitation in radically treated lung cancer: A three-armed randomized controlled trial. J Thorac Dis. 2017;9:1919-29.
Licker M, Karenovics W, Diaper J. Short-term preoperative h-intensity interval training in patients awaiting lung cancer surgery: A randomized controlled trial. J Thorac Oncol 2017;12:323-33.
Persson B, Carringer M, Andren O, Andersson SO, Carlsson J, Ljungqvist O. Initial experiences with the enhanced recovery after surgery (ERAS) protocol in open radical cystectomy. Scand J Urol 2015;49:302-7.
Collins JW, Adding C, Hosseini A. Introducing an enhanced recovery programme to an established totally intracorporeal robot-assisted radical cystectomy service. Scand J Urol 2016;50:39-46.
Lin C, Wan F, Lu Y, Li G, Yu L, Wang M. Enhanced recovery after surgery protocol for prostate cancer patients undergoing laparoscopic radical prostatectomy. J Int Med Res 2019;47:114-21.
Modesitt SC, Sarosiek BM, Trowbridge ER, Redick DL, Shah PM, Thiele RH, et al
. Enhanced recovery implementation in major gynecologic surgeries: Effect of care standardization. Obstet Gynecol 2016;128:457-66.
Thomson K, Pestieau SR, Patel JJ, Gordish-Dressman H, Mirzada A, Kain ZN, et al
. Perioperative surgical home in pediatric settings: Preliminary results. Anesth Analg 2016;123:1193-200.
Qiu C, Cannesson M, Morkos A, Nguyen VT, LaPlace D, Trivedi NS, et al
. Practice and outcomes of the perioperative surgical home in a California integrated delivery system. Anesth Analg 2016;123:597-606.
Vetter TR, Barman J, Hunter JM, Jones KA, Pittet JF. The effect of implementation of preoperative and postoperative care elements of a perioperative surgical home model on outcomes in patients undergoing hip arthroplasty or knee arthroplasty. Anesth Analg 2017;124:1450-8.
Thiele RH, Raghunathan K, Brudney CS. Perioperative Quality Initiative (POQI) I Workgroup. American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on perioperative fluid management within an enhanced recovery pathway for colorectal surgery. Perioper Med (Lond) 2016;5:24-36.
McEvoy MD, Scott MJ, Gordon DB. Perioperative Quality Initiative (POQI) I Workgroup. American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on optimal analgesia within an enhanced recovery pathway for colorectal surgery: Part 1 – From the preoperative period to PACU. Perioper Med (Lond) 2017;6:8.
Scott MJ, McEvoy MD, Gordon DB. Perioperative Quality Initiative (POQI) I Workgroup. American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) Joint Consensus Statement on Optimal Analgesia within an Enhanced Recovery Pathway for Colorectal Surgery: Part 2 – From PACU to the Transition Home. Perioper Med (Lond) 2017;6:7.
Holubar SD, Hedrick T, Gupta R. Perioperative Quality Initiative (POQI) I Workgroup. American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on prevention of postoperative infection within an enhanced recovery pathway for elective colorectal surgery. Perioper Med (Lond) 2017;6:4.
Abola RE, Bennett-Guerrero E, Kent ML. Perioperative Quality Initiative (POQI) 2 Workgroup. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on patient-reported outcomes in an enhanced recovery pathway. Anesth Analg 2018;126:1874-82.
Hedrick TL, McEvoy MD, Mythen MG. Perioperative Quality Initiative (POQI) 2 Workgroup. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on postoperative gastrointestinal dysfunction within an enhanced recovery pathway for elective colorectal surgery. Anesth Analg 2018;126:1896-907.
Wischmeyer PE, Carli F, Evans DC, Guilbert S, Kozar R, Pryor A, et al
. Perioperative Quality Initiative (POQI) 2 Workgroup. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on nutrition screening and therapy within a surgical enhanced recovery pathway. Anesth Analg 2018;126:1883-95.
Day AR, Middleton G, Smith RV, Jourdan IC, Rockall TA. Time to adjuvant chemotherapy following colorectal cancer resection is associated with an improved survival. Colorectal Dis 2014;16:368-72.
Kain ZN, Vakharia S, Garson L, Engwall S, Schwarzkopf R, Gupta R, et al.
The perioperative surgical home as a future perioperative practice model. Anesth Analg 2014;118:1126-30.
Brown S, Brown J. Why do physicians order unnecessary preoperative tests? A qualitative study. Fam Med 2011;43:338-41.
Garson L, Schwarzkopf R, Vakharia S, Alexander B, Stead S, Cannesson M, et al
. Implementation of a total joint replacement- focused perioperative surgical home: A management case report. Anesth Analg 2014;118:1081-9.
[Table 1], [Table 2], [Table 3]