Year : 2008 | Volume
: 52 | Issue : 3 | Page : 288--296
Efficacy and Safety Performance of ProsealTM Laryngeal Mask Airway in Laparoscopic Surgery: Experience of 1000 Cases
Bimla Sharma1, Jayashree Sood2, Chand Sahai1, Ved Prakash Kumra3,
1 Senior Consultant, Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram, Hospital, Old Rajinder Nagar, New Delhi-110060, India
2 Senior Consultant and Chairperson, Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram, Hospital, Old Rajinder Nagar, New Delhi-110060, India
3 Emeritus Consultant, Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram, Hospital, Old Rajinder Nagar, New Delhi-110060, India
Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi-110060
The ProSeal TM laryngeal mask airway (PLMA) has been especially designed for positive pressure ventilation and protection against aspiration. We tested the efficacy and safety of the PLMA as a ventilatory device for a variety of commonly performed laparoscopic surgeries. The PLMA was used for the airway management of one thousand; consecutive anaesthetized, paralysed patients, aged 13-86 years belonging to ASA physical status I-III scheduled for elective laparoscopic and extraperitoneal endoscopic surgeries. Details of insertion, oropharyngeal seal pressure (OSP), ventilatory performance and safety data of the PLMA were recorded. During surgery, oxygenation and ventilation variables were adjusted to maintain SpO2 > 95 %, as measured by pulse oximetry and EtCO2 < 46 mm Hg, respectively. The success rate of PLMA insertion and gastric tube placement was 100 %. One patient had short lived SpO2 of 94 % while three patients showed transient increase in EtCO2 > 55 mm Hg. Twenty five (2.5%) patients showed gastric regurgitation, suctioned through the oesophageal channel of the PLMA, but no case of pulmonary aspiration was detected. Median OSP was 36 cm H2O. The median peak inspiratory pressure (PIP) before and after CO2- insufflation were 10 and 18 cm H2O, respectively (P < 0.001). Our study demonstrated that the PLMA, in experienced hands, is an efficient and safe airway tool for the airway management of patients undergoing elective laparoscopic surgery.
|How to cite this article:|
Sharma B, Sood J, Sahai C, Kumra VP. Efficacy and Safety Performance of ProsealTM Laryngeal Mask Airway in Laparoscopic Surgery: Experience of 1000 Cases.Indian J Anaesth 2008;52:288-296
|How to cite this URL:|
Sharma B, Sood J, Sahai C, Kumra VP. Efficacy and Safety Performance of ProsealTM Laryngeal Mask Airway in Laparoscopic Surgery: Experience of 1000 Cases. Indian J Anaesth [serial online] 2008 [cited 2019 Sep 21 ];52:288-296
Available from: http://www.ijaweb.org/text.asp?2008/52/3/288/60636
The ProSeal™ laryngeal mask airway (PLMA) is a directional perilaryngeal sealer owing to its unique cuff and double tube design that allows an oropharyngeal seal of > 30 cm H 2O without an increase in the directly measured mucosal pressure when compared to the classic laryngeal mask airway (cLMA). ,, It enables positive pressure ventilation (PPV) at higher peak inspiratory pressure (PIP). When properly placed, its drain tube separates the alimentary and respiratory tracts, detects malposition and provides protection against aspiration in fasted patients as supported by design, clinical, laboratory, and cadaveric evidence. ,,,,, These features, together with the flexible, non-kinkable airway tube increase its safety profile. Although the tracheal tube is considered ideal for laparoscopic procedures, there is a consistent inflow of reports highlighting the safety of PLMA in laparoscopic surgery. ,,,,,,, In this prospective study, we evaluated PLMA as an airway management device for a wide variety of commonly performed laparoscopic surgeries. The primary outcome of the study was defined as the efficacy and safety of the device and the secondary outcome to assess the pharyngolaryngeal morbidity.
Following institutional ethics committee approval and written informed consent, this prospective study comprising one thousand consecutive patients, aged 13-86 years, ASA physical status I-III, scheduled for elective laparoscopic surgery was undertaken. Patients with mouth opening less than 2.0 cm, abnormality of neck, upper respiratory and alimentary tract, a body mass index in excess of 40 kg m -2 , previous gastric surgery, hiatus hernia, acute abdomen, poorly controlled diabetes mellitus and those with a risk of pulmonary aspiration were excluded from study. The device was inserted by anaesthesiologists experienced with LMA use (cLMA > 100, PLMA > 50 insertions). The following parameters were studied: i) Ease of insertion and number of attempts, ii) Oropharyngeal seal pressure (OSP) iii) Ventilation: PIP, SpO 2 and EtCO 2, iv) Safety: device displacement, oropharyngeal leak, gastric insufflation, regurgitation and aspiration, and v) Pharyngolaryngeal morbidity. The change in PIP before and after carbon dioxide insufflation was taken as the primary variable. Wherever possible, fibreoptic evaluation of the device placement was done via airway and drain tubes.
A standard general anaesthesia protocol was followed and routine monitoring was applied in all patients. Oral alprazolam 0.25 - 0.5 mg, was given the night before surgery; intravenous midazolam 1-2 mg, ranitidine 50 mg, metoclopramide 10 mg 2 h preoperatively, and glycopyrrolate 0.2 mg intravenously 3045 min before surgery. Anaesthesia was induced with fentanyl 1mcg kg -1 and propofol 2 mg kg -1 and maintained with propofol infusion 2 mg kg -1 hr -1 , sevoflurane 1% and nitrous oxide 66% in oxygen. Neuromuscular blockade was achieved with vecuronium bromide 0.08 mg kg -1 and maintained with 0.02 mg kg -1 boluses. PLMA was inserted after the jaw was relaxed. Tracheal intubation was considered after three failed PLMA insertion attempts. The patient's lungs were ventilated via a circle-CO 2 - absorber breathing system (Penlon Prima SP, AV 900 ventilator, Abingdon, UK). Duration of CO 2 insufflation and anaesthesia were noted in all cases. At the end of surgery, the neuromuscular blockade was reversed with neostigmine 0.05 mg kg -1 and atropine 0.02 mg kg -1 . The patient's mouth was carefully inspected for damage to the tongue, lips and teeth after removing the PLMA.
Airway management and ventilation strategy
Appropriately sized PLMA (# 3 / # 4) in females and (# 4 / # 5) in males and obese females were chosen. The cuff was fully deflated and the posterior aspect lubricated with a clear water based gel (KY jelly, Johnson& Johnson, U.S.A). With the patient's head on a firm 7- cm high pillow, the PLMA was inserted in the pharynx using the index finger or the introducer tool. Where difficult insertion of the PLMA was anticipated, the placement was aided by one of the following techniques: laryngoscope-aided placement, laryngoscope-guided gum elastic bougie/ polyvinylchloride catheter / gastric tube guided insertion technique. Correct placement of the device was confirmed by manual ventilation, expired tidal volume (V T ) of > 8 ml kg -1 , square wave capnography and the gel displacement test.  Posterior folding of the mask was ruled out by inserting either a gastric tube or a PVC suction catheter through the drain tube. The cuff was inflated to a pressure of 60 cm H 2 O using a cuff pressure monitor (Mallinckrodt Medical, Athlone, Ireland). Number of attempts for gastric tube placement was recorded and its correct placement confirmed. Gastric contents were suctioned and measured for volume and pH. The time interval between holding the PLMA to confirmation of correct placement by bilateral air entry on chest auscultation was noted. The device was secured as per manufacturer's recommendation.
Mechanical ventilation was initiated with FiO 2 0.3, V T - 8-10 ml kg -1 , I/E ratio of 1:2 and respiratory rate of 12 per minute. The FiO 2 and respiratory rate were adjusted to maintain SpO 2 > 95 % and EtCO 2 between 35 - 45 mm Hg. The preset insufflation pressure was kept between 12-14 mm Hg for all procedures except in ASA III patients where it was kept between 10-12 mm Hg. The surgeon graded the gastric insufflation on a 4 point score: 0= no gastric insufflation, 1= minimal gastric insufflation, not interfering with surgery, 2= interfering with surgery, but not necessitating change of device, 3= interfering with surgery, and necessitating change of device. Presence of any audible leak during the procedure was recorded.
PLMA ventilatory performance and fibreoptic position
Oropharyngeal seal pressure was determined at fixed gas flow of 5 litre min -1 by closing the expiratory valve of the CO 2 -circle system and recording the airway pressure at which equilibrium was reached (maximum 40 cm H 2 O).  Suboptimal oxygenation was defined as SpO 2 between 90-95 % and hypoxia as SpO2 2 were noted i) after securing airway (baseline), ii) after CO 2 insufflation, iii) intraoperatively every five minutes, iv) after any change of position and upon v) desufflation. Ventilation was considered unsuitable if EtCO 2 exceeded 46 mm Hg and hypoventilation was defined by EtCO 2 > 55 mm Hg. Flexible fibreoptic scope (Olympus LF-2) view of the laryngeal structures was graded on the following scoring system; 4= vocal cords only; 3= vocal cords plus posterior epiglottis (PE); 2= vocal cords plus anterior epiglottis (AE); 1= vocal cords not seen.  The view from the drain tube was catalogued as: hypopharynx (mucosal); oesophageal sphincter open (clear view down the oesophagus); and others (glottis, epiglottis,arytenoids). 
The following intraoperative events and complications were documented: PLMA displacement, oropharyngeal leak, gastric insufflation, oesophageal regurgitation, pulmonary aspiration, bronchospasm, airway obstruction, tongue-lip-dental trauma. The PLMA was removed after completion of procedure, when the patient was wide-awake. Any blood detected on the device on removal was recorded. Secretions over ventral and dorsal aspect of the PLMA were tested for pH with a litmus paper sensitive to changes of 0.5 unit pH from pH 2.5 to 8.5.
Postoperatively, the patients were monitored in the post anaesthesia care unit by an observer, blinded to the technique, for a minimum of 2 hours. Heart rate, arterial pressure, SpO2, respiratory rate, and any incidence of nausea and vomiting were recorded. They were actively questioned about the presence of sore throat, dysphagia and dysarthria in the post anaesthesia care unit and over ensuing 24 hours.
Statistical tests were performed using SPSS software, (10.0 version; SPSS Inc., Chicago, IL, USA) and results are reported as absolute, percentage, range or median (interquartile range). The KolmogorovSmirnov test indicated that data were not normally distributed, hence non-parametric tests; Chi-square, Fisher's exact, Mann-Whitney U and Wilcoxan Sigmoid Rank tests were applied as appropriate. Significance was taken as P 2 insufflation to be clinically significant. The sample size allowed a projected difference of 25% to be detected for the primary variables for a type I error of 0.05 and a power of 1. Other variables tested were PLMA TM device insertion success rates and times, efficacy of seal, fibreoptically anatomic position, orogastric tube insertion success rates and total intraoperative respiratory complications. The variable requiring the largest sample size was aspiration and keeping in mind the low incidence of aspiration with the PLMA in elective surgery, our study of 1000 patient is not sufficiently powered.
The surgical procedures, patient characteristics and details of anaesthesia and airway management are shown in [Table 1]& [Table 2].
PLMA insertion, gastric tube placement success rate and fibreoptic examination.
The PLMA and gastric tube could be placed in all 1000 patients. Size 3 PLMA was used in 256 female patients and size 4 in 239 male patients. First time insertion success rate of PLMA was 86.6% and there was no case of failed insertion. Gastric tube was left in situ in 814 patients, successfully placed on first attempt in all the patients. Fibreoptic examination was conducted in 157 cases [Table 3].
Ventilatory and oxygenation efficacy
[Table 4] shows the oxygenation, ventilation profile and the peri-insufflation data.
Optimal oxygenation was noted in all cases before CO 2 - insufflation. No patient experienced SpO 2 less than 94 % after CO 2 insufflation. Three patients had EtCO 2 in excess of 55 mm Hg after CO 2 - insufflation. The median OSP was 36 (6) cm H 2 O [Table 2] and over a quarter of our patients recorded an upward trend which would have resulted in OSP exceeding 40 cm H 2 O. There was a significant increase in the PIP after CO 2 - insufflation (P Safety data
There was no incidence of intraoperative displacement of the device. Gastric insufflation grade 1 and 2 was noted in two and five patients respectively. There was no case of regurgitation into the bowl of the mask. Gastric contents were suctioned through the oesophageal channel of PLMA in twenty-five (2.5%) patients. Fluid [4.75 ± 9.19 ml (range 0 to 75 ml), pH range 2.5 to 6.5] was aspirated from the gastric tube in 136 (25%) out of 814 patients. No patient had pH less than 6.0 on dorsal and ventral PLMA cuff. No case of pulmonary aspiration was detected.
Postoperative pharyngolaryngeal morbidity
Most complications were minor in nature [Table 5]. Excessive secretions were noted in six patients and blood staining of the mask upon removal was found in 29 patients which increased with number of attempts at insertion (P ,,,,,,,
The fibreoptic view from the drain tube revealed an open upper oesophageal sphincter (UOS) in 1.27% of patients which is in conformity with earlier studies.  It has been suggested that the open UOS may result from reflex relaxation, mechanical stretch or due to exposure to the atmosphere.  One patient had severe down-folding of epiglottis and the other had bilateral infolding of the PLMA cuff partly covering the glottis.
Optimal oxygenation and ventilation was noted in all patients before CO 2 insufflation. Transient suboptimal oxygenation (SpO 2 - 94%) with EtCO 2 peaking at 80 mm Hg was seen in a patient undergoing total extraperitoneal inguinal hernia repair who developed extensive subcutaneous emphysema due to trocar misplacement in the post insufflation period.  Two other patients with EtCO 2 exceeding 55 mm Hg in the post CO 2 insufflation period had severe down-folding of epiglottis in one patient and bilateral medial in-folding of the mask in another. Severe down-folding of the epiglottis impeding the ventilatory function has been reported earlier.  All regained normal values following CO 2 - desufflation at the end of the procedure.
There was no intraoperative displacement of the device. One important feature of PLMA is to prevent gastric insufflation due to the better oropharyngeal seal pressures. Five of our patients had gastric insufflation, not hindering surgery. The reported incidence of gastric insufflation is 0.1 percent.  However it was higher (0.5%) in our patients and might have resulted from PPV during mask ventilation before PLMA insertion. Our patients had low volume gastric aspirate because they were fasting, pain free before or during induction of anaesthesia, received drugs to reduce volume and raise pH of gastric contents. The intraoperative incidence of gastric regurgitation (2.5%) decreased over the period of study and it appears to be linearly influenced by frequency of usage. Though three cases of pulmonary aspiration have been reported following PLMA use in laparoscopic surgery, ,, there was no case of pulmonary aspiration in our study. Various studies suggest that aspiration can be prevented by correctly placed PLMA. ,, Meticulous selection of patients and surgical procedures, optimal management of the placement, maintenance and emergence phases, and use of the PLMA can reduce the risk of aspiration. 
The PLMA formed an effective seal around the glottis in our patients (mean OLP 36 cm of H 2 O). This result is in accordance with previous work. ,,,,,,,,, The proper selection of the size of the PLMA is important for obtaining adequate seal and thereby improving the safety during laparoscopic surgery. Size 3 PLMA is considered a paediatric version in the Caucasian population, but was found appropriate in 42.95 % of our adult Indian female population. We found that the PIP increased significantly (not more than 50% of its original value) after creation of carboperitoneum without impairing the oropharyngeal seal. An OSP twice the PIP before institution of carboperitoneum proved to be a good predictor of the suitability of the device.
Tracheal intubation, considered ideal for laparoscopic procedures is not foolproof against aspiration of gastric contents. Young and Ridley demonstrated that the inflated high volume low pressure cuff of an endotracheal tube develops longitudinal folds and pooled secretions above can trickle down to the lower airways.  Warner and colleagues reported 32.9% cases of aspiration during direct laryngoscopy for intubation and 35.9% during extubation. 
There are no large series regarding the incidence of aspiration, with PLMA and comparative data with cLMA, in laparoscopic surgery. Cook estimated that 1.3 million patients would be required in each study group to determine if the incidence of aspiration was to be brought down to 50 % for PLMA as compared to cLMA. 
Lu and colleagues confirmed adequate airway management and ventilation with PLMA during carboperitoneum for laparoscopic cholecystectomy.  Other workers reported similar results for other laparoscopic procedures. ,,,,,, Maltby and colleagues in a comparative study involving 109 patients undergoing laparoscopic cholecystectomy reported that the PLMA provided equally effective ventilation as the tracheal tube, without clinically significant gastric distension and smoother emergence in non-obese patients.  In another study, Maltby reported a similar incidence of gastric distension in laparoscopic cholecystectomy managed with the cLMA or tracheal intubation. 
Obese patients are expected to have reduced thoracic compliance, increased inspiratory resistance, higher incidence of difficult airways, failed intubation and greater risk of regurgitation.  The PLMA permits high inflation pressure without leak and its performance is superior to the cLMA in these patients. PLMA use has been reported in obese patients with BMI as high as 47-65 kg m -2 . Brain reported increased BMI to be associated with increased OSP.  Although proper positioning of PLMA may be difficult as compared to cLMA, it improves with experience and confirmatory tests. , as substantiated by Keller and colleagues who reported that PLMA provides an adequate short-term airway in grossly and morbidly obese patients, though its use was not justified for long duration procedures for lack of existing evidence. 
Natalini and colleagues showed that there is no clinically significant difference in pulmonary ventilation between obese and non-obese adult patients when the device is correctly placed but higher cuff pressures (>100 cm H 2 O) are required in obese patients to minimize leaks.  In the present study, 123 patients had BMI > 30 kg m-2 including 7 patients with a BMI>40kg m -2 . We used bougie-guided insertion electively in these seven patients. None of these patients had any episode of hypoxia or hypoventilation and OSP maintenance did not require any increase in intracuff pressure.
Blood was detected in 2.9 % of our patients with higher incidence in males (P = 0.02) and increased number of attempts (P > 0.5). This is lower than the reported incidence of 18.2 percent.  The overall low rate of complaints of sore throat and dysphagia in our study may be explained by the limitation of cuff pressures to a maximum of 60 cm H 2 O as recommended by the manufacturer. 
Our study has a number of limitations: It is a descriptive study, with no randomized controls, and comprised several variables (patient characteristics, different surgical procedures and patient positions). The inclusion of obese patients (seven patients with BMI > 40 kg m -2 ) in the study is incidental because of consecutive entry.
Although safety of the PLMA for laparoscopic surgery, is debatable, it is a better option than a cLMA.  Tracheal intubation remains the gold standard in patients for emergency surgery with increased risk of aspiration. The PLMA has been used for laparoscopic and conventional abdominal surgery, in obese patients and for the management of elective and rescue difficult airways. Our study supports the safety of this device in commonly performed laparoscopic procedures as it successfully isolated the respiratory from the gastrointestinal tract. We conclude that in experienced hands and following a strict protocol of insertion, the PLMA is an efficient and safe tool for airway management of elective fasting patients undergoing endoscopic laparoscopic abdominal surgery.
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