Indian Journal of Anaesthesia

CLINICAL INVESTIGATIONS
Year
: 2009  |  Volume : 53  |  Issue : 6  |  Page : 662--666

Comparison of Midazolam and Propofol for BIS-Guided Sedation During Regional Anaesthesia


Priyanka Khurana1, Ankit Agarwal2, RK Verma3, PK Gupta4 
1 Ex.P.G.Student, Deptt. Of Anaesthesiology, BHU, Varanasi, India
2 Sr.Resident, Deptt. Of Anaesthesiology, BHU, Varanasi, India
3 Reader, Deptt. Of Anaesthesiology, BHU, Varanasi, India
4 Professor, Deptt. Of Anaesthesiology, BHU, Varanasi, India

Correspondence Address:
Ankit Agarwal
Sr.Resident, Deptt. Of Anaesthesiology, BHU, Varanasi
India

Regional anaesthesia has become an important anaesthetic technique. Effective sedation is an essential for regional techniques too. This study compares midazolam and propofol in terms of onset& recovery from sedation, dosage and side effects of both the drugs using Bispectral Index monitoring. Ninety eight patients were randomly divided into two groups,one group recieved midazolam infusion while the other recieved propofol infusion until BIS reached 75. We observed Time to reach desired sedation, HR, MABP, time for recovery, dose to reach sedation and for maintenance of sedation and side effects if any. The time to reach required sedation was 11 min in Midazolam group(Group I) while it was 6 min in Propofol group(Group II) (p=0.0). Fall in MABP was greater with propofol. Recovery in with midazolam was slower than with propofol (18.6 ± 6.5 vs 10.10±3.65 min) (p=0.00). We concluded that both midazolam and propofol are effective sedatives, but onset and offset was quicker with propofol, while midazolam was more cardiostable.


How to cite this article:
Khurana P, Agarwal A, Verma R K, Gupta P K. Comparison of Midazolam and Propofol for BIS-Guided Sedation During Regional Anaesthesia.Indian J Anaesth 2009;53:662-666


How to cite this URL:
Khurana P, Agarwal A, Verma R K, Gupta P K. Comparison of Midazolam and Propofol for BIS-Guided Sedation During Regional Anaesthesia. Indian J Anaesth [serial online] 2009 [cited 2020 Aug 8 ];53:662-666
Available from: http://www.ijaweb.org/article.asp?issn=0019-5049;year=2009;volume=53;issue=6;spage=662;epage=666;aulast=Khurana;type=0