Indian Journal of Anaesthesia

CLINICAL INVESTIGATION
Year
: 2011  |  Volume : 55  |  Issue : 6  |  Page : 573--577

Changes in intraocular pressure following administration of suxamethonium and endotracheal intubation: Influence of dexmedetomidine premedication


Chandan Kumar Pal, Manjushree Ray, Anjana Sen, Bimal Hajra, Dipankar Mukherjee, Anil Kumar Ghanta 
 Department of Anaesthesiology, N R S Medical College, Kolkata, West Bengal, India

Correspondence Address:
Manjushree Ray
12/1, A K Point, 68B, APC Roy Road, Kolkata 700 009, West Bengal
India

Background: Use of suxamethonium is associated with an increase in intraocular pressure (IOP) and may be harmful for patients with penetrating eye injuries. The purpose of our study was to observe the efficacy of dexmedetomidine for prevention of rise in IOP associated with the administration of suxamethonium and endotracheal intubation. Methods: Sixty-six American Society of Anaesthesiologists I or II patients undergoing general anaesthesia for non-ophthalmic surgery were included in this randomized, prospective, clinical study. Patients were allocated into three groups to receive 0.4 mg/kg dexmedetomidine (group D4), 0.6 mg/kg dexmedetomidine (group D6) or normal saline (group C) over a period of 10 min before induction. IOP, heart rate and mean arterial pressure were recorded before and after the premedication, after induction, after suxamethonium injection and after endotracheal intubation. Results: Fall in IOP was observed following administration of dexmedetomidine. IOP increased in all three groups after suxamethonium injection and endotracheal intubation, but it never crossed the baseline value in group D4 as well as in group D6. Fall in mean arterial pressure was noticed after dexmedetomidine infusion, especially in the D6 group. Conclusion: Dexmedetomidine (0.6 mg/kg as well as 0.4 mg/kg body weight) effectively prevents rise of IOP associated with administration of suxamethonium and endotracheal intubation. However, dexmedetomidine 0.6 mg/kg may cause significant hypotension. Thus, dexmedetomidine 0.4 mg/kg may be preferred for prevention of rise in IOP.


How to cite this article:
Pal CK, Ray M, Sen A, Hajra B, Mukherjee D, Ghanta AK. Changes in intraocular pressure following administration of suxamethonium and endotracheal intubation: Influence of dexmedetomidine premedication.Indian J Anaesth 2011;55:573-577


How to cite this URL:
Pal CK, Ray M, Sen A, Hajra B, Mukherjee D, Ghanta AK. Changes in intraocular pressure following administration of suxamethonium and endotracheal intubation: Influence of dexmedetomidine premedication. Indian J Anaesth [serial online] 2011 [cited 2020 Jul 6 ];55:573-577
Available from: http://www.ijaweb.org/article.asp?issn=0019-5049;year=2011;volume=55;issue=6;spage=573;epage=577;aulast=Pal;type=0