Indian Journal of Anaesthesia

CLINICAL INVESTIGATION
Year
: 2013  |  Volume : 57  |  Issue : 3  |  Page : 230--235

A simple method for evaluation of the uptake of isoflurane and its comparison with the square root of time model


Ashish Bangaari1, Nidhi Bidyut Panda2, Goverdhan Dutt Puri2 
1 Department of Anaesthesiology and Pain Medicine, Fellow Liver Transplant Anaesthesia, Asan Medical Centre, Seoul, Korea
2 Department of Anaesthesia and Critical Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Goverdhan Dutt Puri
Department of Anaesthesia and Critical Care, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012
India

Background: The square root of time (SqRT) model had been used to predict the uptake of volatile agents. Methods: We studied the rate of uptake of isoflurane in 10 patients using liquid isoflurane infusion through syringe pump into the closed circuit. The infusion rates were titrated to maintain a constant end tidal concentration of isoflurane of 1.5%. The predicted uptake values were also calculated from the square root principle and compared with the derived uptake. Results: The observed rate of uptake was higher than predicted from the Lowe and Ernst equation (P<0.001). There exists considerable inter-individual variability in uptake pharmacokinetics and it showed statistically significant correlation with ideal body weight, body weight (P<0.01), body surface area, and body weight 3/4 from 30 min of start of isoflurane infusion (P<0.05). Conclusion: SqRT model is inaccurate in predicting isoflurane uptake and underestimates it during closed circuit anaesthesia.


How to cite this article:
Bangaari A, Panda NB, Puri GD. A simple method for evaluation of the uptake of isoflurane and its comparison with the square root of time model.Indian J Anaesth 2013;57:230-235


How to cite this URL:
Bangaari A, Panda NB, Puri GD. A simple method for evaluation of the uptake of isoflurane and its comparison with the square root of time model. Indian J Anaesth [serial online] 2013 [cited 2020 Aug 3 ];57:230-235
Available from: http://www.ijaweb.org/article.asp?issn=0019-5049;year=2013;volume=57;issue=3;spage=230;epage=235;aulast=Bangaari;type=0