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CLINICAL INVESTIGATION
Year : 2007  |  Volume : 51  |  Issue : 6  |  Page : 519-524

Correlation of serum oestrogen level with duration of post operative analgesia


1 Sr. Prof. & Head, Department of Anaesthesiology and M. P. Shah Medical College, Jamnagar - 361008, India
2 P.G. Student, Department of Anaesthesiology and M. P. Shah Medical College, Jamnagar - 361008, India
3 Assistant Professor, Department of Anaesthesiology and M. P. Shah Medical College, Jamnagar - 361008, India
4 Former Dean, Department of Anaesthesiology and M. P. Shah Medical College, Jamnagar - 361008, India

Correspondence Address:
Pramod Kumar
Professor and Head, Department ofAnaesthesiology, M.P.Shah Medical College and Guru Gobind Singh Hospital, Jamnagar
India
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Source of Support: None, Conflict of Interest: None


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Sixty female patients ofASAstatus I and II posted for routine surgical procedures like abdominal hysterectomy, exploratory laparotomy, pyelolithotomy, laparoscopic cholecystectomy etc. were studied for correlation of serum oestrogen level and post operative analgesia. The patients were divided into 3 groups, each consisting of 20 patients. Group-I consisted of female patients in Ist phase of menstrual cycle, Group-II of female patients in II nd phase of menstrual cycle& Group-III of female patients in IIIrd phase of menstrual cycle.All patients were premedicated with glycopyrrolate 4μg.kg -1 and midazolam 0.02 mg.kg -1 intravenously just before induction. All patients were given general anaesthesia with sodium thiopentone 5 mg.kg -1 and succinylcholine 1.5 mg.kg -1 and maintained with O 2 + N 2 O=30:70, fentanyl 1 μg.kg -1 pancuronium 0.08mg.kg -1 bolus and .02 mg.kg -1 given in intermit­tent doses. Patients were reversed with neostigmine 50 μg.kg -1 and glycopyrrolate 8 μg.kg -1 given intravenously slowly. All patients were monitored for pulse, BP, SpO2, RR, tidal volume and minute volume. After recovery of patient, when patient complained of pain, buprenorphine 4μg.kg -1 was given intravenously. Additional supplements of diclofenac sodium were given if needed after the effect of buprenorphine was over upto 24 h. Before induction of anaesthesia, 5ml of patient's venous blood was collected to measure serum oestrogen level by ELISA method and analgesia after buprenorphine was assessed by VAS score. The results analysed showed that there was a clinically significant but statistically non significant reduction in 24hr VAS score in Group I& III patients than Group II patients who had a high oestrogen level. A negative correlation between serum oestrogen and mean duration of analgesia further support this, indicating that low serum oestrogen level decreases pain sensitiv­ity and high serum oestrogen level increases pain sensitivity.


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