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CLINICAL INVESTIGATION
Year : 2011  |  Volume : 55  |  Issue : 4  |  Page : 347-351

Dexmedetomidine as an intrathecal adjuvant for postoperative analgesia


1 Department of Anaesthesia, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India
2 Department of General Surgery, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India
3 Department of Orthopaedics, ERA Medical College, Lucknow, Uttar Pradesh, India

Correspondence Address:
Jaishri Bogra
Department of Anaesthesia, C.S.M.M.U., Lucknow, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5049.84841

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Background: Spinal anaesthesia is the most common approach which is used for lower limb surgery. Dexmedetomidine is the recent drug which acts on α2-adrenergic receptors in the dorsal horn of the spinal cord to produce analgesic effects. Aim: Efficacy and safety of intrathecal dexmedetomidine added to ropivacaine. Setting and Design: Randomised double blind trial. Methods: Sixty patients were randomly allocated to receive intrathecally either 3 ml of 0.75% isobaric ropivacaine + 0.5 ml normal saline (Group R) or 3 ml of 0.75% isobaric ropivacaine + 5 μg dexmedetomidine in 0.5 ml of normal saline (Group D). Results: The mean time of sensory regression to S2 was 468.3±36.78 minutes in group D and 239.33±16.8 minutes in group R. Duration of analgesia (time to requirement of first rescue analgesic) was significantly prolonged in group D (478.4±20.9 minutes) as compared to group R (241.67±21.67 minutes). The maximum visual analogue scale score for pain was less in group D (4.4±1.4) as compared to group R (6.8±2.2). Conclusion: The addition of dexmedetomidine to ropivacaine intrathecally produces a prolongation in the duration of the motor and sensory block.


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