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Year : 2013  |  Volume : 57  |  Issue : 1  |  Page : 46-51

Introduction of sugammadex as standard reversal agent: Impact on the incidence of residual neuromuscular blockade and postoperative patient outcome

1 Department of Anaesthesia and Pain Medicine, Royal Perth Hospital; School of Medicine and Pharmacology, the University of Western Australia, Perth WA, Australia
2 Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Perth WA, Australia
3 School of Medicine and Pharmacology, the University of Western Australia, Perth WA, Australia

Correspondence Address:
Thomas Ledowski
Department of Anaesthesia and Pain Medicine, Royal Perth Hospital,Wellington Street Campus, Perth WA
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Source of Support: None, Conflict of Interest: Prof. T. Ledowski has consulted for and received (unrelated) research grants from MSD Australia. However, this study was neither funded nor solicited or influenced by any means by MSD or their affiliates.

DOI: 10.4103/0019-5049.108562

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Background: The aim of this prospective audit was to investigate clinical practice related to muscle relaxant reversal and the impact made by the recent introduction of sugammadex on patient outcome at a tertiary teaching hospital. Methods: Data from all patients intubated at our institution during two epochs of seven consecutive days each was collected prospectively. Directly prior to extubation, the train-of-four (TOF) ratio was assessed quantitatively by an independent observer. Postoperative outcome parameters were complications in the recovery room and radiological diagnosed atelectasis or pneumonia within 30 days. Results: Data from 146 patients were analysed. Three reversal strategies were used: no reversal, neostigmine or sugammadex. The TOF ratio was less than 0.7 in 17 patients (nine no reversal, eight neostigmine) and less than 0.9 in 47 patients (24 no reversal, 19 neostigmine, four sugammadex). Those reversed with sugammadex showed fewer episodes of postoperative oxygen desaturation (15% vs. 33%; P<0.05). TOF ratios of less than 0.7 ( P<0.05) and also <0.9 ( P<0.01) were more likely associated with X-ray results consistent with postoperative atelectasis or pneumonia. Conclusions: Our results suggest a significant impact of residual paralysis on patient outcome. The use of sugammadex resulted in the lowest incidence of residual paralysis.

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