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ORIGINAL ARTICLE
Year : 2017  |  Volume : 61  |  Issue : 10  |  Page : 803-810

The effect of intravenous dextrose administration for prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy: A double-blind, randomised controlled trial


1 Department of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2 Department of Thoracic Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Epidemiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4 Department of Anesthesiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Medical-Surgical Nursing, Student Research Committee, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Maryam Montazemi
Department of Anesthesiology, Imam Khomeini Hospital, Amir Mazandarani Boulevard, Sari
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ija.IJA_420_16

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Background and Aims: Post-operative nausea and vomiting (PONV) is a common and distressing complication after laparoscopic cholecystectomy (LC). The aim of this study was to evaluate the effect of intravenous (IV) dextrose administration for the prophylaxis of PONV after LC. Methods: In a double-blind, randomised controlled trial, a total of 150 female patients who were scheduled for elective LC were randomly assigned into two groups (A and B). Thirty minutes before induction of anaesthesia, patients received an infusion of 500 cc lactated Ringer's solution (Group A) and 5% dextrose in lactated Ringer's solution (Group B) and over a period of 30 min. All patients rated their nausea and vomiting intensity using the verbal rating scale immediately at post-anaesthesia care unit (PACU) arrival; 30, 60, 90 and 120 min after arriving at the PACU and 6, 12 and 24 h after surgery. Results: There was a statistically significant time trend and group effect along with significant differences in time/group interaction effect in both groups for nausea and vomiting scores (P < 0.05). A low negative correlation coefficient was found (r = −0.394, P < 0.001) between blood glucose levels and nausea scores upon PACU arrival. Dextrose administration reduced the odds of vomiting events compared to placebo (estimate: −0.87, odds ratio = 0.42, 95% confidence interval: 0.28–0.64). Conclusion: Administration of IV dextrose before anaesthesia induction may be recommended as an effective, and safe method for the prophylaxis of PONV after LC.


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