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Year : 2020  |  Volume : 64  |  Issue : 8  |  Page : 717-719  

NODIC technique - (Nasal oxygenation during infraglottic coblation) to increase the safe apnoea time

1 Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Otorhinolaryngology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Date of Submission03-Mar-2020
Date of Decision09-May-2020
Date of Acceptance23-Jun-2020
Date of Web Publication31-Jul-2020

Correspondence Address:
Dr. Divya Jain
Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Sector - 12, Chandigarh - 160 012
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ija.IJA_193_20

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How to cite this article:
Jain D, Arora S, Virk R S, Gupta M, Arora K. NODIC technique - (Nasal oxygenation during infraglottic coblation) to increase the safe apnoea time. Indian J Anaesth 2020;64:717-9

How to cite this URL:
Jain D, Arora S, Virk R S, Gupta M, Arora K. NODIC technique - (Nasal oxygenation during infraglottic coblation) to increase the safe apnoea time. Indian J Anaesth [serial online] 2020 [cited 2021 Jan 20];64:717-9. Available from: https://www.ijaweb.org/text.asp?2020/64/8/717/291157


Coblation (plasma ablation) procedures are performed for various infraglottic conditions like subglottic stenosis, laryngeal papillomatosis (LP) to name a few. Various anaesthesia protocols used for these procedures include the use of a smaller sized endotracheal tube but it often hampers the surgical vision or infra glottic jet ventilation, which is associated with the risk of barotrauma. Others include either maintaining spontaneous ventilation, which can lead to a moving surgical field or apnoeic oxygenation with intermittent ventilation, which is limited by short apnoea time and oxygen desaturation leading to frequent disruptions in between the procedure.

Despite the institutional practice of the use of nasal prongs for high flow oxygen during apnoea, there is a paucity of literature on this subject. Therefore, we describe this simple technique of nasalo xygenation during infraglottic coblation (NODIC) at 10–12 L/min of oxygen with a nasal cannula to increase the safe apnoea time in 5 patients scheduled for infraglottic coblation procedures.

All the patients were pre-oxygenated with 100% oxygen at 20 degrees head-up position till fractional end-tidal oxygen was >92%. Nasal cannula @ 6 L/min was connected through the auxillary port of the anaesthesia workstation. Anaesthesia was induced with injection fentanyl 2 mcg/kg with propofol 2–3 mg/kg and injection atracurium 0.5 mg/kg was given for neuromuscular relaxation after confirming mask ventilation. Oxygen flow through nasal prongs was increased to 10–12 L/min once the mask was removed. Without endotracheal intubation, Millers blade with endoscope was inserted, and surgery was allowed to proceed under apnoeic oxygenation with continuous nasal oxygenation through the nasal prongs.[1] Arterial blood gas analysis was performed before the initiation of apnoeic oxygenation (T1) and at the end of the apnoeic period (T2). After the culmination of the procedure, the patients were ventilated, and end-tidal CO2(ETCO2) was measured. Following, the return of spontaneous respiration, neuromuscular blockade was reversed. The patients were shifted out of the operation theatre when the ETCO2 reached the baseline value.

The ETCO2 before and after the apnoeic period, the partial pressure of CO2 (paCO2), the partial pressure of oxygen (paO2), pH, minimum oxygen saturation and complications were also recorded. The time when the face mask was removed to the time either the procedure was complete or the saturation was <92% was defined as a single safe apnoeic time (SAT).

There were 4 children with a mean age of 7 (2–11) years and one adult who had SAT of 24 min. The mean SAT in children was 7.3 (5.5–9.8) min. [Table 1]. The mean increase in CO2 was 3.3 mmHg/min in children and 1.5 mmHg/min in the adult patient. All procedures were accomplished in single apnoeic time without any haemodynamic perturbations or cardiac arrhythmias.
Table 1: The demographic and intraoperative data of 5 patients

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High flow nasal cannula oxygen insufflation provides an oxygen-rich mixture in the pharynx. Due to the negative pressure generated, there is a mass movement of oxygen from the pharynx into the alveoli, which improves the oxygenation and prolongs the safe apnoeic period.[2]

Oxygen was kept at 10–12 L/min for all patients. Despite the higher flow of oxygen/kg in children, the adult patient had a much longer SAT, which could be attributed to relatively lesser oxygen consumption, lower functional residual capacity and degree of stenosis compared to children. In children, even mild to moderate stenosis can result in faster desaturations.

Owing to smaller children with laryngeal pathology we kept the threshold of 92% for single SAT.[3] Although, none of our patients had any airway difficulty, the use of the NODIC technique in this group of patients may pose additional challenges.

The higher baseline PaCO2 levels could be due to the existing laryngeal pathology.[4] Apnoeic ventilation further accentuated this resulting in respiratory acidosis. Rajan et al. observed an increase of 3.7 mmHg CO2/min in their study, which was higher than our series.[5]

Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE)_ is another technique, which uses high-flow nasal oxygen up to 70 L/min, creating a flow depend on positive pharyngeal pressure. Lyons et al. successfully demonstrated the use of THRIVE to increase the apnoeic time during laryngeal surgeries.[6]

Compared to THRIVE, a nasal cannula for apnoeic ventilation is affordable and much easier to administer. Although nasal prongs have been used for apnoeic oxygenation during the peri-intubation period, our series highlights its extended application for short laryngeal procedures with appropriate monitoring. However, further validation by randomised controlled trials is warranted.

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Conflicts of interest

There are no conflicts of interest.

   References Top

Virk RS, Nayak G,Jain D. Miller laryngoscope blade: An aid to pediatric laryngeal surgery. Indian J Otolaryngol Head Neck Surg 2019;71:19-21.  Back to cited text no. 1
Rudlof B, Faldum A, Brandt L. A ventilatory mass flow during apnoea: Investigations on quantification. Anaesthesist 2010;59:401-9.  Back to cited text no. 2
Olayan L, Alatassi A, Patel J, Milton S. Apnoeic oxygenation by nasal cannula during airway management in children undergoing general anaesthesia: A pilot randomised controlled trial. Perioper Med (Lond) 2018;7:3.  Back to cited text no. 3
Rezaie-Majd A, Bigenzahn W, Denk DM, Burian M, Kornfehl J, Grasl MCh,et al. Superimposed high-frequency jet ventilation (SHFJV) for endoscopic laryngotracheal surgery in more than 1500 patients. Br J Anaesth 2006;96:650-9.  Back to cited text no. 4
Rajan S, Joseph N, Tosh P, Kadapamannil D, Paul J, Kumar L. Effectiveness of transnasal humidified rapid-insufflation ventilatory exchange versus traditional preoxygenation followed by apnoeic oxygenation in delaying desaturation during apnoea: A preliminary study. Indian J Anaesth 2018;62:202-7.  Back to cited text no. 5
[PUBMED]  [Full text]  
Lyons C, Callaghan M. Apnoeic oxygenation with high-flow nasal oxygen for laryngeal surgery: A case series. Anaesthesia 2017;72:1379-87.  Back to cited text no. 6


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