Comparison of analgesic efficacy of flupirtine maleate and ibuprofen in gynaecological ambulatory surgeries: A randomized controlled trial :Vanita Ahuja, Sukanya Mitra, Sunita Kazal, Anju Huria, Indian Journal of Anaesthesia (IJA)

CLINICAL INVESTIGATION
Year : 2015 | Volume : 59 | Issue : 7 | Page : 411--415

Comparison of analgesic efficacy of flupirtine maleate and ibuprofen in gynaecological ambulatory surgeries: A randomized controlled trial

Vanita Ahuja¹, Sukanya Mitra¹, Sunita Kazal¹, Anju Huria²
¹ Department of Anaesthesia and Intensive Care, Government Medical College and Hospital, Chandigarh, India
² Department of Obstetrics and Gynaecology, Government Medical College and Hospital, Chandigarh, India

Correspondence Address:
Vanita Ahuja
Department of Anaesthesia and Intensive Care, Government Medical College and Hospital, Sector 32 Chandigarh
India

Background and Aims: Flupirtine maleate is a centrally acting, non-opioid analgesic with unique muscle relaxant properties as compared to common analgesics. The aim of this study was to compare post-operative analgesic efficacy of flupirtine maleate and ibuprofen in patients undergoing gynaecological ambulatory surgeries. Methods: This prospective, randomised controlled study was conducted in 60 women of American Society of Anesthesiologists physical status I/II, 18-70 years of age and scheduled to undergo gynaecological ambulatory surgeries. The participants were randomised to receive either 100 mg oral flupirtine maleate (group flupirtine, n = 30) or 800 mg oral ibuprofen (group ibuprofen, n = 30), 1 h prior to surgery and then every 8 h for 48 h. Verbal Numerical Rating Scale (VNRS) on movement was assessed at 0, 2, 4, 6 and 8 h following surgery. Following discharge from hospital, the patients were interviewed telephonically at 12, 24 and 48 h post-operatively. VNRS was statistically analysed using Mann-Whitney test. Results: VNRS on movement was statistically reduced at 2 h after surgery (P = 0.04) in group flupirtine as compared to group ibuprofen. The analgesic efficacy was similar in both the groups at 4, 6, 8, 12, 24 and 48 h after surgery. The satisfaction scores at 24 and 48 h post-operatively were superior in group flupirtine as compared to group ibuprofen (P < 0.001). Conclusion: Analgesic efficacy of flupirtine maleate was comparable with ibuprofen in patients in ambulatory gynaecological patients up to 48 h postoperatively with superior satisfaction scores.

How to cite this article:
Ahuja V, Mitra S, Kazal S, Huria A. Comparison of analgesic efficacy of flupirtine maleate and ibuprofen in gynaecological ambulatory surgeries: A randomized controlled trial.Indian J Anaesth 2015;59:411-415

How to cite this URL:
Ahuja V, Mitra S, Kazal S, Huria A. Comparison of analgesic efficacy of flupirtine maleate and ibuprofen in gynaecological ambulatory surgeries: A randomized controlled trial. Indian J Anaesth [serial online] 2015 [cited 2021 Feb 28 ];59:411-415
Available from: https://www.ijaweb.org/article.asp?issn=0019-5049;year=2015;volume=59;issue=7;spage=411;epage=415;aulast=Ahuja;type=0