Indian Journal of Anaesthesia

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 60  |  Issue : 11  |  Page : 848--851

Efficacy of methylprednisolone and lignocaine on propofol injection pain: A randomised, double-blind, prospective study in adult cardiac surgical patients


Shivaprakash Shivanna, Shio Priye, Dipali Singh, Sathyanarayan Jagannath, Syed Mudassar, Durga Prasad Reddy 
 Department of Cardiac Anaesthesiology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India

Correspondence Address:
Sathyanarayan Jagannath
Department of Cardiac Anaesthesiology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka
India

Background and Aims: Propofol (2, 6-di-isopropylphenol) used for the induction of anaesthesia often causes mild to severe pain or discomfort on injection. We designed this double-blind study to compare the efficacy of methylprednisolone and lignocaine in reducing the pain of propofol injection in patients scheduled for cardiac surgery. Methods: A total of 165 adult patients, scheduled for elective cardiac surgery, were divided into three groups: saline (group S, n = 55), lignocaine 20 mg (Group L, n = 55) and methylprednisolone 125 mg diluted into 2 ml of distilled water (Group MP, n = 55). Drugs were administered after tourniquet application and occlusion was released after 1 min and 1/4 th of the total dose of propofol (2 mg/kg) was administered at the rate of 0.5 ml/s. Pain on propofol injection was evaluated by four-point verbal rating scale. Statistical methods used included Student«SQ»s t-test and Chi-square test/Fisher«SQ»s exact test. Results: The overall incidence of pain was 70.9% in the saline group, 30.9% in the lignocaine group and 36.4% in the methylprednisolone group. The intensity of pain was significantly less in patients receiving methylprednisolone and lignocaine than those receiving saline (P < 0.012). Conclusion: Pre-treatment with intravenous methylprednisolone was found to be as effective as lignocaine in reducing propofol injection-induced pain.


How to cite this article:
Shivanna S, Priye S, Singh D, Jagannath S, Mudassar S, Reddy DP. Efficacy of methylprednisolone and lignocaine on propofol injection pain: A randomised, double-blind, prospective study in adult cardiac surgical patients.Indian J Anaesth 2016;60:848-851


How to cite this URL:
Shivanna S, Priye S, Singh D, Jagannath S, Mudassar S, Reddy DP. Efficacy of methylprednisolone and lignocaine on propofol injection pain: A randomised, double-blind, prospective study in adult cardiac surgical patients. Indian J Anaesth [serial online] 2016 [cited 2021 Jan 22 ];60:848-851
Available from: https://www.ijaweb.org/article.asp?issn=0019-5049;year=2016;volume=60;issue=11;spage=848;epage=851;aulast=Shivanna;type=0